ECSP055548A - Derivados de piperidina biciclicos como antagonistas del receptor quimioquinas ccr1 - Google Patents

Derivados de piperidina biciclicos como antagonistas del receptor quimioquinas ccr1

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Publication number
ECSP055548A
ECSP055548A EC2005005548A ECSP055548A ECSP055548A EC SP055548 A ECSP055548 A EC SP055548A EC 2005005548 A EC2005005548 A EC 2005005548A EC SP055548 A ECSP055548 A EC SP055548A EC SP055548 A ECSP055548 A EC SP055548A
Authority
EC
Ecuador
Prior art keywords
ccr1
chemioquines
antagonists
bicycle
receiver
Prior art date
Application number
EC2005005548A
Other languages
English (en)
Inventor
Laura Cook Blumberg
Matthew Frank Brown
Matthew Merrill Hayward
Christopher Stanley Poss
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of ECSP055548A publication Critical patent/ECSP055548A/es

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    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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Abstract

Compuesto de fórmula (ver gráfico) en la que a,b,c, R1, R2, R3, R4, R5,R6, Q, W, Y, y Z son como se definieron anteriormente, útiles como potentes y selectivos inhibidores de la unión de MIP-1 (CCL3) a su receptor CCR1 hallado en células (preferiblemente leucocitos y linfocitos) inflamatorias e inmunomoduladoras.
EC2005005548A 2002-07-18 2005-01-18 Derivados de piperidina biciclicos como antagonistas del receptor quimioquinas ccr1 ECSP055548A (es)

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US39726302P 2002-07-18 2002-07-18

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ECSP055548A true ECSP055548A (es) 2005-03-10

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US (1) US20040063688A1 (es)
EP (1) EP1525201A1 (es)
JP (1) JP2005533845A (es)
KR (1) KR20050028036A (es)
CN (1) CN1668614A (es)
AP (1) AP2005003196A0 (es)
AR (1) AR040586A1 (es)
AU (1) AU2003281527A1 (es)
BR (1) BR0312699A (es)
CA (1) CA2492110A1 (es)
EA (1) EA200500033A1 (es)
EC (1) ECSP055548A (es)
GT (1) GT200300147A (es)
IL (1) IL166075A0 (es)
IS (1) IS7615A (es)
MA (1) MA27327A1 (es)
MX (1) MXPA05000757A (es)
OA (1) OA12886A (es)
PA (1) PA8577401A1 (es)
PE (1) PE20040668A1 (es)
TN (1) TNSN05013A1 (es)
TW (1) TW200401639A (es)
UY (1) UY27896A1 (es)
WO (1) WO2004009588A1 (es)

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US7479496B2 (en) 2004-02-19 2009-01-20 Bristol-Myers Squibb Company Substituted spiro azabicyclics as modulators of chemokine receptor activity
US7288563B2 (en) 2004-02-19 2007-10-30 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7230022B2 (en) 2004-02-19 2007-06-12 Bristol-Myers Squibb Company Substituted fused bicyclic amines as modulators of chemokine receptor activity
US7381738B2 (en) 2004-02-19 2008-06-03 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
GB0409236D0 (en) * 2004-04-26 2004-05-26 Novartis Ag Organic compounds
US7713990B2 (en) 2005-01-13 2010-05-11 Neurosearch A/S 3,8-substituted 8-AZA-bicyclo[3.2.1]octane derivatives and their use as monomine neurotransmitter re-uptake inhibitors
ES2277745B1 (es) * 2005-06-14 2008-06-01 Laboratorios Almirall S.A. Derivados n-amida de 8-azabiciclo /3.2.1/oct-3-ilo como antagonistas de ccr1.
US20070105874A1 (en) * 2005-09-23 2007-05-10 Conforma Therapeutics Corporation Anti-Tumor Methods Using Multi Drug Resistance Independent Synthetic HSP90 Inhibitors
ITFI20120062A1 (it) * 2012-03-21 2013-09-22 Minerva Patents S A Componenti per il trattamento di malattie correlate a ischemia-riperfusione.
MX368059B (es) 2013-07-18 2019-09-18 Novartis Ag Inhibidores de autotaxina que comprenden un núcleo de anillo heteroaromático de bencil-amida cíclica.
CN104122392B (zh) * 2014-06-24 2016-05-25 上海交通大学医学院附属瑞金医院 检测ccl15趋化因子的试剂在制备筛选甲状腺滤泡癌试剂中的应用

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AR028947A1 (es) * 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
PA8575901A1 (es) * 2002-07-18 2004-07-20 Pfizer Prod Inc Derivados de piperidina novedosos

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