ECSP055630A - MICROBIOLOGICAL PROCEDURES TO PREPARE 11a-HYDROXYSTEROIDS 7a-REPLACED - Google Patents

MICROBIOLOGICAL PROCEDURES TO PREPARE 11a-HYDROXYSTEROIDS 7a-REPLACED

Info

Publication number
ECSP055630A
ECSP055630A EC2005005630A ECSP055630A ECSP055630A EC SP055630 A ECSP055630 A EC SP055630A EC 2005005630 A EC2005005630 A EC 2005005630A EC SP055630 A ECSP055630 A EC SP055630A EC SP055630 A ECSP055630 A EC SP055630A
Authority
EC
Ecuador
Prior art keywords
hydroxysteroids
prepare
replaced
microbiological procedures
compounds
Prior art date
Application number
EC2005005630A
Other languages
Spanish (es)
Inventor
Peter Muhn
Reinhard Nubbemeyer
Rolf Bohlmann
Ludwig Zorn
Norbert Gallus
Hermann Kuenzer
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10233723A external-priority patent/DE10233723A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of ECSP055630A publication Critical patent/ECSP055630A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C12P33/10—Hydroxylating at 11 position at 11 alpha-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C12P33/16—Acting at 17 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se describe una novedosa síntesis para preparar productos precursores destinados a la producción de compuestos de la fórmula general (8,10,12). Durante dicha síntesis se producen los compuestos de la fórmula general (4,B) en una reacción microbiológica. Los significados de los radicales R7, R10, R11, R13, R17 y R17'y del grupo U-V-W-X-Y-Z se indican en las reivindicaciones.A novel synthesis is described for preparing precursor products intended for the production of compounds of the general formula (8,10,12). During said synthesis the compounds of the general formula (4, B) are produced in a microbiological reaction. The meanings of the radicals R7, R10, R11, R13, R17 and R17 'and of the group U-V-W-X-Y-Z are indicated in the claims.

EC2005005630A 2002-07-24 2005-02-24 MICROBIOLOGICAL PROCEDURES TO PREPARE 11a-HYDROXYSTEROIDS 7a-REPLACED ECSP055630A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10233723A DE10233723A1 (en) 2002-07-24 2002-07-24 Preparation of 7 alpha-substituted 11 alpha-hydroxy-steroids, useful as precursors for new androgenic 7 alpha,17 alpha-substituted 11 beta-halo-steroids, by microbiological conversion of 7 alpha-substituted steroids
US40295302P 2002-08-14 2002-08-14

Publications (1)

Publication Number Publication Date
ECSP055630A true ECSP055630A (en) 2005-04-18

Family

ID=31189296

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005630A ECSP055630A (en) 2002-07-24 2005-02-24 MICROBIOLOGICAL PROCEDURES TO PREPARE 11a-HYDROXYSTEROIDS 7a-REPLACED

Country Status (19)

Country Link
EP (1) EP1523568A2 (en)
JP (1) JP4417838B2 (en)
KR (1) KR101041328B1 (en)
CN (1) CN100339486C (en)
BR (1) BR0313210A (en)
CA (1) CA2492079C (en)
CO (1) CO5690563A2 (en)
CR (1) CR7672A (en)
EA (2) EA008147B1 (en)
EC (1) ECSP055630A (en)
HR (1) HRP20050172A2 (en)
IL (1) IL166358A0 (en)
MX (1) MXPA05001024A (en)
NO (1) NO20050980L (en)
NZ (2) NZ549529A (en)
PH (1) PH12005500143B1 (en)
PL (1) PL373808A1 (en)
RS (1) RS51855B (en)
WO (1) WO2004011663A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1947107B1 (en) * 2005-10-27 2012-10-17 SRI International Process for production of steroid compound
RU2377309C1 (en) * 2008-04-22 2009-12-27 Валентина Александровна Андрюшина MICROBIOLOGICAL METHOD FOR PREPARATION OF 7α-HYDROXYANDROSTENES
CN103834712B (en) * 2012-11-26 2016-03-30 复旦大学 The optimization method of desogestrel intermediate nanometer liposome bio-transformation
CN103214543B (en) * 2012-12-25 2015-09-02 中国人民解放军海军医学研究所 New Crategolic acid derivative, its preparation method and the application in antitumor drug thereof
CN104862323B (en) * 2015-06-02 2018-01-16 中国农业科学院生物技术研究所 Modify the '-hydroxylase gene of diphenol compounds
PL246071B1 (en) * 2022-08-26 2024-11-25 Wrocław University Of Environmental And Life Sciences Method of producing 11α-hydroxy-19-nortestosterone

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE496261A (en) 1949-06-11
US2658023A (en) * 1953-04-21 1953-11-03 Pfizer & Co C Oxygenation of steroids
US2985563A (en) 1958-11-13 1961-05-23 Schering Corp 11alpha-hydroxylation of steroids by glomerella
US3004047A (en) 1959-03-13 1961-10-10 Olin Mathieson 6alpha-halo-11alpha-hydroxy steroids of the pregnane series and esters thereof
US3341557A (en) * 1961-06-05 1967-09-12 Upjohn Co 7-methyltestosterones
US3203869A (en) 1962-10-11 1965-08-31 Syntex Corp 11alpha-hydroxylation of 6-substituted-11-desoxy steroids with microorganisms of thegenus fusarium, liseola section
US5342834A (en) 1989-04-07 1994-08-30 The Population Council, Inc. Method for androgen supplementation
EP1167381A3 (en) 1995-12-11 2004-09-29 G.D. Searle & Co. Process for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and Intermediates useful therein
NZ325276A (en) 1995-12-12 1999-11-29 Akzo Nobel Nv Microbial method of in vitro transformation of a steroid into the 11a-hydroxy analogue using oxygen and a micro-organism
GB9525194D0 (en) 1995-12-12 1996-02-07 Zeneca Ltd Pharmaceutical composition
US6767902B2 (en) 1997-09-17 2004-07-27 The Population Council, Inc. Androgen as a male contraceptive and non-contraceptive androgen replacement
US20020012694A1 (en) * 1997-09-17 2002-01-31 Alfred J. Moo-Young Transdermal administration of ment
US5952319A (en) 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
HK1049442B (en) 2000-02-15 2007-06-15 Bayer Schering Pharma Aktiengesellschaft Male contraceptive formulation comprising norethisterone and testosterone undecanoate
DE10104327A1 (en) * 2001-01-24 2002-07-25 Schering Ag New 11beta-halo-testosterone derivatives useful in male hormone replacement therapy and in male fertility control
CA2493207A1 (en) * 2002-07-25 2004-02-05 Schering Aktiengesellschaft Composition containing an androgenous 11.beta.-halogen steroid and a progestational hormone, and male contraceptive based on said composition

Also Published As

Publication number Publication date
EA010572B1 (en) 2008-10-30
IL166358A0 (en) 2006-01-16
EA200500224A1 (en) 2005-08-25
JP2006503813A (en) 2006-02-02
EA008147B1 (en) 2007-04-27
CO5690563A2 (en) 2006-10-31
WO2004011663A2 (en) 2004-02-05
JP4417838B2 (en) 2010-02-17
CA2492079A1 (en) 2004-02-05
CN1671858A (en) 2005-09-21
BR0313210A (en) 2005-06-28
PL373808A1 (en) 2005-09-19
KR20050026507A (en) 2005-03-15
CR7672A (en) 2006-05-29
CA2492079C (en) 2012-01-10
HRP20050172A2 (en) 2005-04-30
MX260952B (en) 2008-10-01
EA200601030A1 (en) 2006-10-27
CN100339486C (en) 2007-09-26
RS20050045A (en) 2007-06-04
NO20050980L (en) 2005-02-23
RS51855B (en) 2012-02-29
WO2004011663A3 (en) 2004-07-15
NZ549529A (en) 2008-04-30
HK1081999A1 (en) 2006-05-26
AU2003281677A1 (en) 2004-02-16
NZ537871A (en) 2006-10-27
WO2004011663A9 (en) 2004-05-06
EP1523568A2 (en) 2005-04-20
PH12005500143B1 (en) 2011-03-25
MXPA05001024A (en) 2005-05-16
KR101041328B1 (en) 2011-06-14

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