ECSP055631A - ANTRANILAMIDOPIRIMIDINAS THAT INHIBIT VEGFR-2 AND VEGFR-3 - Google Patents

ANTRANILAMIDOPIRIMIDINAS THAT INHIBIT VEGFR-2 AND VEGFR-3

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Publication number
ECSP055631A
ECSP055631A EC2005005631A ECSP055631A ECSP055631A EC SP055631 A ECSP055631 A EC SP055631A EC 2005005631 A EC2005005631 A EC 2005005631A EC SP055631 A ECSP055631 A EC SP055631A EC SP055631 A ECSP055631 A EC SP055631A
Authority
EC
Ecuador
Prior art keywords
vegfr
diseases
compounds
inhibit
cases
Prior art date
Application number
EC2005005631A
Other languages
Spanish (es)
Inventor
Andreas Menrad
Ludwig Zorn
Andreas Huth
Martin Krueger
Stuart Ince
Karl-Heinz Thierauch
Martin Haberey
Stump Holger Hess
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10235690A external-priority patent/DE10235690A1/en
Priority claimed from DE10328036A external-priority patent/DE10328036A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of ECSP055631A publication Critical patent/ECSP055631A/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • A61P9/08—Vasodilators for multiple indications
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    • A—HUMAN NECESSITIES
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

Se describen antranilamidopiridinamidas que inhiben VEGFR-2 y VEGFR-3, su preparación y su uso como medicamento para el tratamiento de enfermedades originadas por angiogénesis persistente y productos intermedios para la preparación de los compuestos. Los compuestos de la invención se pueden usar en casos de crecimiento de tumores o metástasis, psoriasis, sarcoma de Kaposi, restenosis, como p. ej. restenosis inducida por stent, endometriosis, enfermedad de Crohn, mal de Hodgkins, leucemia, artritis, tal como artritis reumatoide, hemangioma, angiofibroma, enfermedades oculares tales como retinopatía diabética, glaucoma neovascular, enfermedades renales como glomeronefritis, nefropatía diabética, nefroesclerosis maligna, síndromes microangiopáticos trómbicos, rechazos de transplantes y glomerulopatía, enfermedades fibróticas como cirrosis hepática, enfermedades proliferativas de células mesangiales, arterioesclerosis, lesiones del tejido nervioso para inhibir la reoclusión de vasos después de tratamiento de catéter de balón hinchable, en casos de prótesis vasculares o después de colocar dispositivos mecánicos para mantener abiertos los vasos, como p. ej. stents, como inmunosupresor, para la curación de heridas sin cicatriz, para léntigo senil y dermatitis de contacto. Tales compuestos también pueden ser usados como inhibidores de VEGFR-3 en la angiogénesis linfática.Anthranilamidopyridinamides that inhibit VEGFR-2 and VEGFR-3, their preparation and their use as a medicament for the treatment of diseases caused by persistent angiogenesis and intermediates for the preparation of the compounds are described. The compounds of the invention can be used in cases of tumor growth or metastasis, psoriasis, Kaposi's sarcoma, restenosis, such as e.g. ex. stent-induced restenosis, endometriosis, Crohn's disease, Hodgkins disease, leukemia, arthritis, such as rheumatoid arthritis, hemangioma, angiofibroma, eye diseases such as diabetic retinopathy, neovascular glaucoma, kidney diseases such as glomeronephritis, diabetic nephropathy, nephrosclerosis, malignant syndromes trombic microangiopathic, transplant rejection and glomerulopathy, fibrotic diseases such as liver cirrhosis, proliferative diseases of mesangial cells, arteriosclerosis, nerve tissue lesions to inhibit reocclusion of vessels after inflatable balloon catheter treatment, in cases of vascular prostheses or after place mechanical devices to keep the vessels open, such as p. ex. stents, as an immunosuppressant, for healing wounds without a scar, for senile lentigo and contact dermatitis. Such compounds can also be used as VEGFR-3 inhibitors in lymphatic angiogenesis.

EC2005005631A 2002-07-31 2005-02-24 ANTRANILAMIDOPIRIMIDINAS THAT INHIBIT VEGFR-2 AND VEGFR-3 ECSP055631A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10235690A DE10235690A1 (en) 2002-07-31 2002-07-31 New N-benzyl-anthranilic acid (hetero)arylamide derivatives and analogs, are tyrosine kinase KDR and FLT inhibitors and angiogenesis inhibitors, useful e.g. for treating tumors, psoriasis or restenosis
DE10328036A DE10328036A1 (en) 2003-06-19 2003-06-19 New N-benzyl-anthranilic acid (hetero)arylamide derivatives and analogs, are tyrosine kinase KDR and FLT inhibitors and angiogenesis inhibitors, useful e.g. for treating tumors, psoriasis or restenosis

Publications (1)

Publication Number Publication Date
ECSP055631A true ECSP055631A (en) 2005-04-18

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EC2005005631A ECSP055631A (en) 2002-07-31 2005-02-24 ANTRANILAMIDOPIRIMIDINAS THAT INHIBIT VEGFR-2 AND VEGFR-3

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EP (1) EP1594841A1 (en)
JP (2) JP4777648B2 (en)
KR (1) KR20050026535A (en)
CN (1) CN1671666A (en)
AU (1) AU2003281855A1 (en)
BR (1) BR0313122A (en)
CA (1) CA2493026C (en)
CO (1) CO5720998A2 (en)
CR (1) CR7673A (en)
EC (1) ECSP055631A (en)
HR (1) HRP20050187A2 (en)
IL (1) IL166377A0 (en)
MX (1) MXPA04012948A (en)
NO (1) NO20051035L (en)
PL (1) PL374610A1 (en)
RS (1) RS20050084A (en)
RU (1) RU2005105683A (en)
WO (1) WO2004013102A1 (en)

Families Citing this family (37)

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Publication number Priority date Publication date Assignee Title
US7615565B2 (en) 2002-07-31 2009-11-10 Bayer Schering Pharma Aktiengesellschaft VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
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