ECSP055793A - Forma de administración de ibuprofeno sódico - Google Patents
Forma de administración de ibuprofeno sódicoInfo
- Publication number
- ECSP055793A ECSP055793A EC2005005793A ECSP055793A ECSP055793A EC SP055793 A ECSP055793 A EC SP055793A EC 2005005793 A EC2005005793 A EC 2005005793A EC SP055793 A ECSP055793 A EC SP055793A EC SP055793 A ECSP055793 A EC SP055793A
- Authority
- EC
- Ecuador
- Prior art keywords
- weight
- tablet
- hydrated sodium
- core
- ibuprofen
- Prior art date
Links
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
- 229910052708 sodium Inorganic materials 0.000 title 1
- 239000011734 sodium Substances 0.000 title 1
- PTTPUWGBPLLBKW-UHFFFAOYSA-M sodium;2-[4-(2-methylpropyl)phenyl]propanoate Chemical compound [Na+].CC(C)CC1=CC=C(C(C)C([O-])=O)C=C1 PTTPUWGBPLLBKW-UHFFFAOYSA-M 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000036765 blood level Effects 0.000 abstract 1
- 239000002360 explosive Substances 0.000 abstract 1
- 229960001680 ibuprofen Drugs 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una tableta no efervescente de ibuprofeno, que consta de un núcleo y, si se desea, de una cubierta de azúcar o pelicular, en la que el núcleo de la tableta contiene del 50 al 100 % en peso de ibuprofeno sódico hidratado y del 50 al 0 % en peso de componente auxiliar, porcentajes referidos al peso del núcleo, y no contiene lubricante ni "explosivo" alguno, y en la que el ibuprofeno sódico hidratado lleva un contenido en agua del 8 al 16 % en peso, con preferencia del 11 al 16 % en peso, dicha tableta posee una dureza suficiente, es relativamente pequeña y conduce a un aumento especialmente rápido del nivel en sangre y, por tanto, a un efecto analgésico de iniciación acelerada. En contra de la opinión dominante en la técnica anterior, el ibuprofeno sódico hidratado que tenga un contenido en agua idóneo es apropiado en grado suficiente para el prensado.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH01703/02A CH693586A8 (de) | 2002-10-14 | 2002-10-14 | Darreichungsform von Ibuprofen-Natrium. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP055793A true ECSP055793A (es) | 2005-08-11 |
Family
ID=28796671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2005005793A ECSP055793A (es) | 2002-10-14 | 2005-05-13 | Forma de administración de ibuprofeno sódico |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US20040102522A1 (es) |
| EP (1) | EP1410793B1 (es) |
| JP (1) | JP4608316B2 (es) |
| KR (1) | KR101046894B1 (es) |
| CN (1) | CN100592909C (es) |
| AR (1) | AR041428A1 (es) |
| AT (1) | ATE309789T1 (es) |
| AU (1) | AU2003266094B2 (es) |
| BR (1) | BRPI0315248B1 (es) |
| CA (1) | CA2500987A1 (es) |
| CH (1) | CH693586A8 (es) |
| CO (1) | CO5700709A2 (es) |
| DE (1) | DE50301661D1 (es) |
| DK (1) | DK1410793T3 (es) |
| EA (1) | EA007914B1 (es) |
| EC (1) | ECSP055793A (es) |
| ES (1) | ES2249702T3 (es) |
| HR (1) | HRP20050429A2 (es) |
| IL (1) | IL167357A (es) |
| MA (1) | MA27490A1 (es) |
| MX (1) | MXPA05003592A (es) |
| MY (1) | MY132858A (es) |
| NO (1) | NO20052343L (es) |
| NZ (1) | NZ539405A (es) |
| PA (1) | PA8586101A1 (es) |
| PE (1) | PE20040417A1 (es) |
| PL (1) | PL376177A1 (es) |
| SI (1) | SI1410793T1 (es) |
| TW (1) | TWI262800B (es) |
| UA (1) | UA86751C2 (es) |
| WO (1) | WO2004035024A1 (es) |
| ZA (1) | ZA200502925B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3920358A1 (de) * | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US6705028B2 (en) * | 2001-09-12 | 2004-03-16 | Honda Giken Kogyo Kabushiki Kaisha | Self-propelled snowplow vehicle |
| US20050176809A1 (en) * | 2004-02-05 | 2005-08-11 | Rodlen Laboratories, Inc. | Method and compositions for treatment of painful disorders |
| JP2008509207A (ja) * | 2004-08-12 | 2008-03-27 | レキット ベンキーザー ヘルスケア （ユーケイ） リミテッド | 溶融押出しにより作製するパラセタモール、ｎｓａｉｄ及び糖アルコールを含む顆粒 |
| US20070077297A1 (en) * | 2004-09-30 | 2007-04-05 | Scolr Pharma, Inc. | Modified release ibuprofen dosage form |
| EP1854463A4 (en) | 2005-03-03 | 2011-03-23 | Takeda Pharmaceutical | COMPOSITION WITH CONTROLLED RELEASE |
| PT2559430E (pt) | 2005-03-22 | 2015-10-09 | Stada Arzneimittel Ag | Ibuprofeno solubilizado |
| EP1800667A1 (en) | 2005-12-23 | 2007-06-27 | Losan Pharma GmbH | Rapidly solubilizing ibuprofen granulate |
| DE102006029233A1 (de) * | 2006-06-26 | 2007-12-27 | Liedtke, Rainer K., Dr. | Formulierungen zur Verbesserung der Verträglichkeit nichtsteroidaler Antiphlogistika |
| CL2007002425A1 (es) * | 2006-08-22 | 2008-06-27 | Albermarle Corp | Procedimiento de preparacion controlado de sal sodica de ibuprofeno de tamano de particula mediano; y dichas particulas de sal sodica. |
| FI20080348A0 (fi) * | 2008-02-15 | 2008-05-09 | Atacama Labs Oy | Uudenlainen farmaseuttinen formulaatio |
| US7749537B2 (en) * | 2006-12-04 | 2010-07-06 | Scolr Pharma, Inc. | Method of forming a tablet |
| US9629806B2 (en) | 2008-07-21 | 2017-04-25 | Si Group, Inc. | High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms |
| US9629809B2 (en) | 2008-07-21 | 2017-04-25 | Si Group, Inc. | High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms |
| EP2323976A4 (en) * | 2008-08-14 | 2014-07-02 | Shasun Chemicals And Drugs Ltd | ARYLALKYLCARBOXYLIC ACID SALTS, PROCESS FOR PREPARATION THEREOF AND GALENIC FORMS |
| UA102128C2 (en) * | 2008-12-05 | 2013-06-10 | Х. Луннбек А/С | Nalmefene hydrochloride dihydrate |
| AU2015264861C1 (en) * | 2009-06-22 | 2017-11-16 | Pf Consumer Healthcare 1 Llc | Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen |
| TWI504393B (zh) * | 2009-06-22 | 2015-10-21 | 惠氏有限責任公司 | 製備包含異丁苯丙酸鈉之醫藥組合物之方法 |
| AU2014200704C1 (en) * | 2009-06-22 | 2018-12-06 | Pf Consumer Healthcare 1 Llc | Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen |
| FR2997856B1 (fr) * | 2012-11-14 | 2015-04-24 | Pf Medicament | Pastille medicamenteuse a base d'ibuprofene sodique dihydrate |
| EP2965746B1 (en) | 2014-07-10 | 2019-03-13 | Santa Farma Ilaç Sanayi A.S. | An oral pharmaceutical composition comprising ibuprofen, ibuprofen sodium dihydrate, pseudoephedrine hydrochloride and chlorpheniramine maleate |
| US20180078516A1 (en) * | 2016-09-19 | 2018-03-22 | Innovazone Labs LLC | Pharmaceutical Composition of Ibuprofen Sodium for Oral Administration |
| CN113893227B (zh) * | 2021-11-18 | 2023-04-14 | 山东则正医药技术有限公司 | 布洛芬片的制备原料、制备方法和布洛芬片 |
| CN119488489A (zh) * | 2024-11-29 | 2025-02-21 | 华中药业股份有限公司 | 一种布洛芬片及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5104648A (en) * | 1989-02-02 | 1992-04-14 | Mallinckrodt Specialty Chemicals Company | High ibuprofen content granulations |
| US4911921A (en) * | 1989-02-02 | 1990-03-27 | Mallinckrodt, Inc. | High ibuprofen content granulations |
| GB8920693D0 (en) * | 1989-09-13 | 1989-10-25 | Nicholas Kiwi Pty Ltd | Non-effervescent ibuprofen compositions |
| CA2061520C (en) * | 1991-03-27 | 2003-04-22 | Lawrence J. Daher | Delivery system for enhanced onset and increased potency |
| GB9224021D0 (en) * | 1992-11-16 | 1993-01-06 | Boots Co Plc | Effervescent compositions |
| US6083430A (en) * | 1994-10-28 | 2000-07-04 | Fuisz Technologies Ltd. | Method of preparing a dosage unit by direct tableting and product therefrom |
| GB9603699D0 (en) * | 1996-02-21 | 1996-04-17 | Boots Co Plc | Therapeutic composition |
| IT1301966B1 (it) * | 1998-07-30 | 2000-07-20 | Zambon Spa | Composizioni farmaceutiche ad attivita' analgesica |
-
2002
- 2002-10-14 CH CH01703/02A patent/CH693586A8/de not_active IP Right Cessation
-
2003
- 2003-04-03 DK DK03405225T patent/DK1410793T3/da active
- 2003-04-03 EP EP03405225A patent/EP1410793B1/de not_active Expired - Lifetime
- 2003-04-03 ES ES03405225T patent/ES2249702T3/es not_active Expired - Lifetime
- 2003-04-03 SI SI200330125T patent/SI1410793T1/sl unknown
- 2003-04-03 DE DE50301661T patent/DE50301661D1/de not_active Expired - Fee Related
- 2003-04-03 AT AT03405225T patent/ATE309789T1/de not_active IP Right Cessation
- 2003-09-10 UA UAA200504484A patent/UA86751C2/ru unknown
- 2003-09-22 TW TW092126096A patent/TWI262800B/zh active
- 2003-09-29 AR ARP030103544A patent/AR041428A1/es unknown
- 2003-09-30 MY MYPI20033728A patent/MY132858A/en unknown
- 2003-10-09 AU AU2003266094A patent/AU2003266094B2/en not_active Expired - Fee Related
- 2003-10-09 BR BRPI0315248A patent/BRPI0315248B1/pt not_active IP Right Cessation
- 2003-10-09 KR KR1020057006414A patent/KR101046894B1/ko not_active Expired - Fee Related
- 2003-10-09 NZ NZ539405A patent/NZ539405A/en unknown
- 2003-10-09 MX MXPA05003592A patent/MXPA05003592A/es active IP Right Grant
- 2003-10-09 CA CA002500987A patent/CA2500987A1/en not_active Abandoned
- 2003-10-09 JP JP2004543886A patent/JP4608316B2/ja not_active Expired - Fee Related
- 2003-10-09 CN CN200380101345A patent/CN100592909C/zh not_active Expired - Fee Related
- 2003-10-09 WO PCT/CH2003/000662 patent/WO2004035024A1/en not_active Ceased
- 2003-10-09 PL PL03376177A patent/PL376177A1/xx not_active Application Discontinuation
- 2003-10-09 EA EA200500649A patent/EA007914B1/ru not_active IP Right Cessation
- 2003-10-09 HR HR20050429A patent/HRP20050429A2/xx not_active Application Discontinuation
- 2003-10-10 PE PE2003001033A patent/PE20040417A1/es not_active Application Discontinuation
- 2003-10-13 PA PA20038586101A patent/PA8586101A1/es unknown
- 2003-10-14 US US10/683,283 patent/US20040102522A1/en not_active Abandoned
-
2005
- 2005-03-09 IL IL167357A patent/IL167357A/en not_active IP Right Cessation
- 2005-04-11 ZA ZA200502925A patent/ZA200502925B/en unknown
- 2005-05-09 MA MA28268A patent/MA27490A1/fr unknown
- 2005-05-10 CO CO05044513A patent/CO5700709A2/es not_active Application Discontinuation
- 2005-05-12 NO NO20052343A patent/NO20052343L/no not_active Application Discontinuation
- 2005-05-13 EC EC2005005793A patent/ECSP055793A/es unknown
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