ECSP056038A - Procedimiento para la preparación de un polimorfo de maleato de rosiglitazona - Google Patents
Procedimiento para la preparación de un polimorfo de maleato de rosiglitazonaInfo
- Publication number
- ECSP056038A ECSP056038A EC2005006038A ECSP056038A ECSP056038A EC SP056038 A ECSP056038 A EC SP056038A EC 2005006038 A EC2005006038 A EC 2005006038A EC SP056038 A ECSP056038 A EC SP056038A EC SP056038 A ECSP056038 A EC SP056038A
- Authority
- EC
- Ecuador
- Prior art keywords
- preparation
- rosiglitazona
- procedure
- maleate polymorph
- polymorph
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 4
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 title 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 title 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 title 1
- 229940125904 compound 1 Drugs 0.000 abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 2
- 230000008025 crystallization Effects 0.000 abstract 2
- 239000003999 initiator Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 abstract 1
- 229960003271 rosiglitazone maleate Drugs 0.000 abstract 1
- SUFUKZSWUHZXAV-BTJKTKAUSA-N rosiglitazone maleate Chemical compound [H+].[H+].[O-]C(=O)\C=C/C([O-])=O.C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O SUFUKZSWUHZXAV-BTJKTKAUSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un procedimiento de cristalización para la preparación de un polimorfo de maleato de rosiglitazona (compuesto 1), y un procedimiento para la preparación del compuesto 1 con una pureza polimórfica que es adecuada para su uso como un material iniciador en un procedimiento de cristalización para la preparación del compuesto 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0307259.2A GB0307259D0 (en) | 2003-03-28 | 2003-03-28 | Process |
| PCT/GB2004/001306 WO2004085435A1 (en) | 2003-03-28 | 2004-03-25 | Process for preparing a polymorph of rosiglitazone maleate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP056038A true ECSP056038A (es) | 2006-01-27 |
Family
ID=9955778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2005006038A ECSP056038A (es) | 2003-03-28 | 2005-09-26 | Procedimiento para la preparación de un polimorfo de maleato de rosiglitazona |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20070167494A1 (es) |
| EP (1) | EP1615918A1 (es) |
| JP (1) | JP2006521340A (es) |
| KR (1) | KR20050120670A (es) |
| CN (1) | CN1768057A (es) |
| AU (2) | AU2004224068A1 (es) |
| BR (1) | BRPI0408752A (es) |
| CA (1) | CA2520249A1 (es) |
| EA (1) | EA009331B1 (es) |
| EC (1) | ECSP056038A (es) |
| GB (1) | GB0307259D0 (es) |
| IS (1) | IS8087A (es) |
| MA (1) | MA27727A1 (es) |
| MX (1) | MXPA05010413A (es) |
| NO (1) | NO20054911L (es) |
| OA (1) | OA13042A (es) |
| WO (1) | WO2004085435A1 (es) |
| ZA (1) | ZA200507100B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020137940A1 (en) | 1997-12-16 | 2002-09-26 | Smithkline Beecham P.L.C. | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
| US20040248945A1 (en) | 1999-04-23 | 2004-12-09 | Smithkline Beecham P.L.C. | Thiazolidinedione derivative and its use as antidiabetic |
| GB2405403A (en) * | 2003-08-29 | 2005-03-02 | Cipla Ltd | Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base |
| ITMI20041537A1 (it) * | 2004-07-28 | 2004-10-28 | Chemi Spa | Nuova forma polimorfa del rosiglitazone maleato |
| CZ298424B6 (cs) * | 2005-05-24 | 2007-09-26 | Zentiva, A. S. | Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel |
| MY199695A (en) | 2017-01-27 | 2023-11-18 | Neurocrine Biosciences Inc | Methods for the administration of certain vmat2 inhibitors |
| DK3684333T3 (da) | 2017-09-21 | 2025-05-12 | Neurocrine Biosciences Inc | Valbenazin-formulering med høj dosis og sammensætninger, fremgangsmåder og kits relateret hertil |
| US20200230127A1 (en) | 2017-10-10 | 2020-07-23 | Neurocrine Biosciences, Inc. | Methods for the Administration of Certain VMAT2 Inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| GB9723295D0 (en) * | 1997-11-04 | 1998-01-07 | Smithkline Beecham Plc | Novel process |
| RS50114B (sr) * | 1999-04-23 | 2009-03-25 | Smithkline Beecham P.L.C., | Novi polimorfni oblik 5-/4-/2-(n-metil- n-(2-piridil)amino/ etoksi/benzil/ tiazolidin-2,4-dion, soli maleinske kiseline |
| EA003031B1 (ru) * | 1999-04-23 | 2002-12-26 | Смитклайн Бичам Плс | Новый фармацевтический препарат |
| CN1167702C (zh) * | 1999-04-23 | 2004-09-22 | 史密丝克莱恩比彻姆有限公司 | 5-[4-[2-n-甲基-n-(2-吡啶基)氨基]乙氧基]苄基]噻唑烷-2,4-二酮马来酸盐的多晶型物 |
| AU9123201A (en) * | 2000-09-26 | 2002-04-08 | Reddy S Res Foundation | Novel polymorphic forms of 5-(4-(2-(N-methyl-N-(2-pyridyl)amino)ethoxy)benzyl) thiazolidine-2,4-dione maleate and process for their preparation |
-
2003
- 2003-03-28 GB GBGB0307259.2A patent/GB0307259D0/en not_active Ceased
-
2004
- 2004-03-25 JP JP2006506028A patent/JP2006521340A/ja not_active Withdrawn
- 2004-03-25 EP EP04723254A patent/EP1615918A1/en not_active Withdrawn
- 2004-03-25 EA EA200501527A patent/EA009331B1/ru unknown
- 2004-03-25 OA OA1200500267A patent/OA13042A/en unknown
- 2004-03-25 CN CNA2004800083916A patent/CN1768057A/zh active Pending
- 2004-03-25 AU AU2004224068A patent/AU2004224068A1/en not_active Abandoned
- 2004-03-25 WO PCT/GB2004/001306 patent/WO2004085435A1/en not_active Ceased
- 2004-03-25 BR BRPI0408752-6A patent/BRPI0408752A/pt not_active IP Right Cessation
- 2004-03-25 CA CA002520249A patent/CA2520249A1/en not_active Abandoned
- 2004-03-25 US US10/551,021 patent/US20070167494A1/en not_active Abandoned
- 2004-03-25 KR KR1020057018143A patent/KR20050120670A/ko not_active Withdrawn
- 2004-03-25 MX MXPA05010413A patent/MXPA05010413A/es unknown
-
2005
- 2005-09-05 ZA ZA200507100A patent/ZA200507100B/en unknown
- 2005-09-26 EC EC2005006038A patent/ECSP056038A/es unknown
- 2005-10-11 MA MA28549A patent/MA27727A1/fr unknown
- 2005-10-24 IS IS8087A patent/IS8087A/is unknown
- 2005-10-24 NO NO20054911A patent/NO20054911L/no not_active Application Discontinuation
-
2008
- 2008-10-30 AU AU2008237610A patent/AU2008237610A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008237610A1 (en) | 2008-11-27 |
| EP1615918A1 (en) | 2006-01-18 |
| GB0307259D0 (en) | 2003-05-07 |
| US20070167494A1 (en) | 2007-07-19 |
| NO20054911L (no) | 2005-10-24 |
| EA200501527A1 (ru) | 2006-02-24 |
| OA13042A (en) | 2006-11-10 |
| CN1768057A (zh) | 2006-05-03 |
| AU2004224068A1 (en) | 2004-10-07 |
| KR20050120670A (ko) | 2005-12-22 |
| MXPA05010413A (es) | 2005-11-04 |
| JP2006521340A (ja) | 2006-09-21 |
| BRPI0408752A (pt) | 2006-03-28 |
| MA27727A1 (fr) | 2006-01-02 |
| EA009331B1 (ru) | 2007-12-28 |
| ZA200507100B (en) | 2006-07-26 |
| WO2004085435A1 (en) | 2004-10-07 |
| CA2520249A1 (en) | 2004-10-07 |
| IS8087A (is) | 2005-10-24 |
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