ECSP056112A - RECOMBINANT ANTIBODIES AND FRAGMENTS RECOGNIZING GANGLIOSIDE N-GLICOLIL GM3 AND ITS USE FOR DIAGNOSIS AND TUMOR TREATMENT - Google Patents

RECOMBINANT ANTIBODIES AND FRAGMENTS RECOGNIZING GANGLIOSIDE N-GLICOLIL GM3 AND ITS USE FOR DIAGNOSIS AND TUMOR TREATMENT

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Publication number
ECSP056112A
ECSP056112A ECSP056112A ECSP056112A EC SP056112 A ECSP056112 A EC SP056112A EC SP056112 A ECSP056112 A EC SP056112A EC SP056112 A ECSP056112 A EC SP056112A
Authority
EC
Ecuador
Prior art keywords
ganglioside
glycolyl
glicolil
diagnosis
recombinant antibodies
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Navarro Lourdes Tatiana Roque
De Acosta Del Rio Cristina Maria Mateo
Gonzalez Mabel Rodriguez
Dorantes Gertrudis Rojas
Perez Ariel Talavera
Frias Ernesto Moreno
Original Assignee
De Acosta Del Rio Cristina Maria Mateo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by De Acosta Del Rio Cristina Maria Mateo filed Critical De Acosta Del Rio Cristina Maria Mateo
Priority to ECSP056112 priority Critical patent/ECSP056112A/en
Publication of ECSP056112A publication Critical patent/ECSP056112A/en

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se relaciona fundamentalmente con la producción de inmunoglobulinas menos inmunogénicas por la vía de la ingeniería genética, y más específicamente con un anticuerpo monoclonal que reconoce antígenos que contienen el gangliósido N-glicolil GM3 y no otros gangliósidos del tipo N-glicolil o N-acetil, ni a los glicolípidos sulfatados. Más específicamente la presente invención se relaciona con las secuencias peptídicas que codifican un anticuerpo monoclonal recombinante contra el gangliósido n-glicolil GM3, o fragmentos derivados del mismo y composiciones farmacéuticas conteniendo dicho anticuerpo o sus fragmentos y su uso tanto diagnostico o terapéutico en cáncer de mama y melanoma.The present invention relates primarily to the production of less immunogenic immunoglobulins by genetic engineering, and more specifically to a monoclonal antibody that recognizes antigens containing the ganglioside N-glycolyl GM3 and no other gangliosides of the N-glycolyl or N type -acetyl, or sulfated glycolipids. More specifically, the present invention relates to the peptide sequences encoding a recombinant monoclonal antibody against the n-glycolyl GM3 ganglioside, or fragments derived therefrom and pharmaceutical compositions containing said antibody or its fragments and its diagnostic or therapeutic use in breast cancer. and melanoma

ECSP056112 2005-10-21 2005-10-21 RECOMBINANT ANTIBODIES AND FRAGMENTS RECOGNIZING GANGLIOSIDE N-GLICOLIL GM3 AND ITS USE FOR DIAGNOSIS AND TUMOR TREATMENT ECSP056112A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP056112 ECSP056112A (en) 2005-10-21 2005-10-21 RECOMBINANT ANTIBODIES AND FRAGMENTS RECOGNIZING GANGLIOSIDE N-GLICOLIL GM3 AND ITS USE FOR DIAGNOSIS AND TUMOR TREATMENT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP056112 ECSP056112A (en) 2005-10-21 2005-10-21 RECOMBINANT ANTIBODIES AND FRAGMENTS RECOGNIZING GANGLIOSIDE N-GLICOLIL GM3 AND ITS USE FOR DIAGNOSIS AND TUMOR TREATMENT

Publications (1)

Publication Number Publication Date
ECSP056112A true ECSP056112A (en) 2006-04-19

Family

ID=40203023

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP056112 ECSP056112A (en) 2005-10-21 2005-10-21 RECOMBINANT ANTIBODIES AND FRAGMENTS RECOGNIZING GANGLIOSIDE N-GLICOLIL GM3 AND ITS USE FOR DIAGNOSIS AND TUMOR TREATMENT

Country Status (1)

Country Link
EC (1) ECSP056112A (en)

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