ECSP066933A - Sal de clopidogrel y sus formas polimorfas - Google Patents

Sal de clopidogrel y sus formas polimorfas

Info

Publication number
ECSP066933A
ECSP066933A EC2006006933A ECSP066933A ECSP066933A EC SP066933 A ECSP066933 A EC SP066933A EC 2006006933 A EC2006006933 A EC 2006006933A EC SP066933 A ECSP066933 A EC SP066933A EC SP066933 A ECSP066933 A EC SP066933A
Authority
EC
Ecuador
Prior art keywords
polymorphic forms
clopidogrel salt
clopidogrel
salt
dihydrothiene
Prior art date
Application number
EC2006006933A
Other languages
English (en)
Inventor
Keith Richard Lorimer
Alicia Tee Fuay Ng
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ECSP066933A publication Critical patent/ECSP066933A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La invención se refiere a naftaleno-1,5-disulfonato de (+)-(S)-a-(2-clorofenil)-6,7-dihidrotieno[3,2-c]piridina-5(4H)-acetato de metilo, o a una de sus formas polimorfas y/o a uno de sus hidratos y/o a uno de sus solvatos, a composiciones farmacéuticas que los contienen, y al método de su uso para inhibir la agregación plaquetaria.
EC2006006933A 2004-04-20 2006-10-17 Sal de clopidogrel y sus formas polimorfas ECSP066933A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56379504P 2004-04-20 2004-04-20
PCT/US2005/013279 WO2005103059A1 (en) 2004-04-20 2005-04-18 Clopidogrel salt and polymorphic forms thereof

Publications (1)

Publication Number Publication Date
ECSP066933A true ECSP066933A (es) 2006-12-20

Family

ID=34966351

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006933A ECSP066933A (es) 2004-04-20 2006-10-17 Sal de clopidogrel y sus formas polimorfas

Country Status (20)

Country Link
US (2) US7652139B2 (es)
EP (1) EP1740594A1 (es)
JP (1) JP2007533746A (es)
KR (1) KR20070012676A (es)
CN (1) CN1997647A (es)
AU (1) AU2005236046A1 (es)
BR (1) BRPI0510008A (es)
CA (1) CA2561006A1 (es)
CR (1) CR8651A (es)
EA (1) EA010829B1 (es)
EC (1) ECSP066933A (es)
IL (1) IL178216A0 (es)
MA (1) MA28510B1 (es)
MX (1) MXPA06012128A (es)
NO (1) NO20065322L (es)
NZ (1) NZ551374A (es)
TN (1) TNSN06311A1 (es)
UA (1) UA84335C2 (es)
WO (1) WO2005103059A1 (es)
ZA (1) ZA200608035B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2562532C (en) * 2004-04-09 2010-02-16 Hanmi Pharm. Co., Ltd. Crystalline clopidogrel naphthalenesulfonate or hydrate thereof, method for preparing same and pharmaceutical composition containing same
KR100945062B1 (ko) * 2006-03-22 2010-03-05 한미약품 주식회사 클로피도그렐 1,5-나프탈렌디술폰산염 및 이의 수화물의제조방법
CN100396687C (zh) * 2006-05-26 2008-06-25 浙江海翔药业股份有限公司 (+)-(s-)-氯吡格雷硫酸氢盐(i型)的制备方法
WO2008060934A2 (en) * 2006-11-14 2008-05-22 Acusphere, Inc. Formulations of tetrahydropyridine antiplatelet agents for parenteral or oral administration
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2425983C3 (de) 1973-06-12 1978-09-14 Toyama Chemical Co. Ltd., Tokio Sulfonsäuresalze von Acylcholinen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzung
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
IL162461A0 (en) * 2001-12-18 2005-11-20 Teva Pharma Polymorphs of clopidogrel hydrogensulfate
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
SE0201661D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
CZ297472B6 (cs) * 2002-08-27 2006-12-13 Zentiva, A.S. Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I
DE10305984A1 (de) 2003-02-13 2004-09-02 Helm Ag Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
ES2531088T3 (es) 2003-04-25 2015-03-10 Cadila Healthcare Ltd Sales de clopidogrel y procedimiento de preparación
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
GB0325603D0 (en) 2003-11-03 2003-12-10 Sandoz Ag Organic compounds
WO2005068471A1 (en) 2004-01-13 2005-07-28 Zentiva, A.S. New crystalline forms of clopidogrel hydrobromide and methods of their preparation
CN1922188A (zh) 2004-02-24 2007-02-28 齐格弗里德通用国际股份公司 氯吡格雷之药学可接受的盐

Also Published As

Publication number Publication date
UA84335C2 (ru) 2008-10-10
EA200601922A1 (ru) 2007-02-27
US20100227882A1 (en) 2010-09-09
NO20065322L (no) 2006-11-20
US7652139B2 (en) 2010-01-26
MA28510B1 (fr) 2007-04-03
KR20070012676A (ko) 2007-01-26
EA010829B1 (ru) 2008-12-30
WO2005103059A1 (en) 2005-11-03
AU2005236046A1 (en) 2005-11-03
BRPI0510008A (pt) 2007-09-18
CA2561006A1 (en) 2005-11-03
ZA200608035B (en) 2008-07-30
MXPA06012128A (es) 2007-01-31
NZ551374A (en) 2010-08-27
CR8651A (es) 2007-08-28
IL178216A0 (en) 2006-12-31
EP1740594A1 (en) 2007-01-10
US20070088048A1 (en) 2007-04-19
TNSN06311A1 (en) 2007-12-03
CN1997647A (zh) 2007-07-11
JP2007533746A (ja) 2007-11-22

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