ECSP066959A - MACROCICLICAL COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION - Google Patents

MACROCICLICAL COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION

Info

Publication number
ECSP066959A
ECSP066959A EC2006006959A ECSP066959A ECSP066959A EC SP066959 A ECSP066959 A EC SP066959A EC 2006006959 A EC2006006959 A EC 2006006959A EC SP066959 A ECSP066959 A EC SP066959A EC SP066959 A ECSP066959 A EC SP066959A
Authority
EC
Ecuador
Prior art keywords
compounds
methods
macrociclical
inhibitors
viral replication
Prior art date
Application number
EC2006006959A
Other languages
Spanish (es)
Inventor
Lawrence M Blatt
Steven Mak Wenglowsky
Steven Wade Andrews
Yutong Jiang
April Layne Kennedy
Kevin Ronald Condroski
John Anthony Josey
Peter John Stengel
Machender R Madduru
George Andrew Doherty
Benjamin T Woodard
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of ECSP066959A publication Critical patent/ECSP066959A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

En diversas realizaciones se proveen compuestos de las Fórmulas generales I-XIX, así como composiciones, entre las que se incluyen composiciones farmacéuticas, que comprenden un compuesto de la invención. Las realizaciones proveen además métodos de tratamiento, que incluyen métodos de tratamiento de infecciones flavivirales, que incluyen la infección por el virus de hepatitis C y métodos de tratar la fibrosis hepática. Los métodos consisten en general en la administración a un individuo que lo necesita, una cantidad eficaz de un compuesto o composición de la invención.In various embodiments, compounds of General Formulas I-XIX are provided, as well as compositions, including pharmaceutical compositions, which comprise a compound of the invention. The embodiments further provide treatment methods, which include methods of treating flaviviral infections, which include hepatitis C virus infection and methods of treating liver fibrosis. The methods generally consist of administering to an individual in need, an effective amount of a compound or composition of the invention.

EC2006006959A 2004-03-30 2006-10-27 MACROCICLICAL COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION ECSP066959A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55816104P 2004-03-30 2004-03-30
US56241804P 2004-04-14 2004-04-14
US61238104P 2004-09-22 2004-09-22
US61246004P 2004-09-22 2004-09-22

Publications (1)

Publication Number Publication Date
ECSP066959A true ECSP066959A (en) 2006-12-20

Family

ID=35005653

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006959A ECSP066959A (en) 2004-03-30 2006-10-27 MACROCICLICAL COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION

Country Status (16)

Country Link
EP (1) EP1749007A2 (en)
JP (1) JP4950026B2 (en)
AP (1) AP2006003763A0 (en)
AR (1) AR050321A1 (en)
AU (1) AU2005228894B9 (en)
BR (1) BRPI0509467A (en)
CA (1) CA2560897C (en)
CU (1) CU23787B7 (en)
EA (1) EA012389B1 (en)
EC (1) ECSP066959A (en)
GE (1) GEP20104926B (en)
IL (1) IL177917A0 (en)
MA (1) MA28548B1 (en)
NO (1) NO20064933L (en)
NZ (1) NZ549697A (en)
WO (1) WO2005095403A2 (en)

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Also Published As

Publication number Publication date
JP4950026B2 (en) 2012-06-13
NO20064933L (en) 2006-12-15
WO2005095403A2 (en) 2005-10-13
AU2005228894B2 (en) 2011-08-25
CU23787B7 (en) 2012-03-15
EA012389B1 (en) 2009-10-30
CU20090209A7 (en) 2011-04-26
AP2006003763A0 (en) 2006-10-31
IL177917A0 (en) 2006-12-31
EP1749007A2 (en) 2007-02-07
NZ549697A (en) 2009-12-24
BRPI0509467A (en) 2007-09-11
AU2005228894A1 (en) 2005-10-13
AR050321A1 (en) 2006-10-18
JP2007531749A (en) 2007-11-08
CA2560897A1 (en) 2005-10-13
EA200601467A1 (en) 2007-06-29
GEP20104926B (en) 2010-03-25
AU2005228894B9 (en) 2011-10-13
WO2005095403A3 (en) 2005-12-01
CA2560897C (en) 2012-06-12
MA28548B1 (en) 2007-04-03

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