ECSP066992A - ACID 2 - {[2- (2-METHYLAMINOPIRIMIDIN-4-IL) -1H-INDOL-5-CARBONYL] AMINO} -3- (PHENYLPIRIDIN-2-ILAMINO) PROPERLY PURELY INHIBITOR OF THE IKB KINASE INHIBITOR - Google Patents
ACID 2 - {[2- (2-METHYLAMINOPIRIMIDIN-4-IL) -1H-INDOL-5-CARBONYL] AMINO} -3- (PHENYLPIRIDIN-2-ILAMINO) PROPERLY PURELY INHIBITOR OF THE IKB KINASE INHIBITORInfo
- Publication number
- ECSP066992A ECSP066992A EC2006006992A ECSP066992A ECSP066992A EC SP066992 A ECSP066992 A EC SP066992A EC 2006006992 A EC2006006992 A EC 2006006992A EC SP066992 A ECSP066992 A EC SP066992A EC SP066992 A ECSP066992 A EC SP066992A
- Authority
- EC
- Ecuador
- Prior art keywords
- inhibitor
- phenylpiridin
- methylaminopirimidin
- ilamino
- indol
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención está dirigida al compuesto sustancialmente puro de fórmula (A), (A)o una sal farmacéuticamente aceptable, o solvato de dicho compuesto; a una composición farmacéutica que comprende una cantidad farmacéuticamente eficaz del compuesto de fórmula (A), y un vehículo farmacéuticamente aceptable; y al uso de un compuesto de fórmula (A) que tiene actividad como inhibidor, preferiblemente un inhibidor selectivo, de IkB (IKK), en particular IKK-2, y a métodos relacionados con ello.The present invention is directed to the substantially pure compound of formula (A), (A) or a pharmaceutically acceptable salt, or solvate of said compound; to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula (A), and a pharmaceutically acceptable carrier; and to the use of a compound of formula (A) having activity as an inhibitor, preferably a selective inhibitor, of IkB (IKK), in particular IKK-2, and related methods.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57014604P | 2004-05-12 | 2004-05-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP066992A true ECSP066992A (en) | 2006-12-29 |
Family
ID=34969825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2006006992A ECSP066992A (en) | 2004-05-12 | 2006-11-10 | ACID 2 - {[2- (2-METHYLAMINOPIRIMIDIN-4-IL) -1H-INDOL-5-CARBONYL] AMINO} -3- (PHENYLPIRIDIN-2-ILAMINO) PROPERLY PURELY INHIBITOR OF THE IKB KINASE INHIBITOR |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1747215A1 (en) |
| JP (1) | JP2007537266A (en) |
| KR (1) | KR20070011483A (en) |
| CN (1) | CN1950359A (en) |
| AR (1) | AR049274A1 (en) |
| AU (1) | AU2005245834A1 (en) |
| BR (1) | BRPI0511029A (en) |
| CA (1) | CA2566213A1 (en) |
| EC (1) | ECSP066992A (en) |
| GT (1) | GT200500111A (en) |
| IL (1) | IL178992A0 (en) |
| MA (1) | MA28553B1 (en) |
| MX (1) | MXPA06012870A (en) |
| NO (1) | NO20065719L (en) |
| PA (1) | PA8633101A1 (en) |
| PE (1) | PE20060269A1 (en) |
| RU (1) | RU2006143758A (en) |
| SV (1) | SV2006002111A (en) |
| TN (1) | TNSN06338A1 (en) |
| TW (1) | TW200605881A (en) |
| UY (1) | UY28897A1 (en) |
| WO (1) | WO2005113544A1 (en) |
| ZA (1) | ZA200608712B (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19951360A1 (en) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituted indoles |
| DE102004033406A1 (en) * | 2004-07-10 | 2006-02-16 | Sanofi-Aventis Deutschland Gmbh | Process for the preparation of the enantiomeric forms of 2,3-diaminopropionic acid derivatives |
| EP2025674A1 (en) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs |
| KR101449785B1 (en) | 2008-04-21 | 2014-10-14 | 오토노미, 인코포레이티드 | Auris formulations for treating otic diseases and conditions |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| WO2011107494A1 (en) | 2010-03-03 | 2011-09-09 | Sanofi | Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof |
| KR20130069641A (en) * | 2010-04-27 | 2013-06-26 | 허치슨 메디파르마 리미티드 | Pyrimidinyl indole compounds |
| EP2582709B1 (en) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| EP2683704B1 (en) | 2011-03-08 | 2014-12-17 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2766349B1 (en) | 2011-03-08 | 2016-06-01 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| JP7033789B2 (en) | 2016-06-29 | 2022-03-11 | オトノミー，インク． | Triglyceride ear preparation and its use |
| CN106588803A (en) * | 2016-11-16 | 2017-04-26 | 西南科技大学 | Novel method for preparing 5-acetylisoxazole |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10237722A1 (en) * | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indole or benzimidazole derivatives for the modulation of IKappaB kinase |
-
2005
- 2005-05-11 BR BRPI0511029-7A patent/BRPI0511029A/en not_active IP Right Cessation
- 2005-05-11 PE PE2005000524A patent/PE20060269A1/en not_active Application Discontinuation
- 2005-05-11 RU RU2006143758/04A patent/RU2006143758A/en not_active Application Discontinuation
- 2005-05-11 WO PCT/US2005/016381 patent/WO2005113544A1/en not_active Ceased
- 2005-05-11 EP EP05749733A patent/EP1747215A1/en not_active Withdrawn
- 2005-05-11 MX MXPA06012870A patent/MXPA06012870A/en not_active Application Discontinuation
- 2005-05-11 JP JP2007513292A patent/JP2007537266A/en not_active Abandoned
- 2005-05-11 AU AU2005245834A patent/AU2005245834A1/en not_active Abandoned
- 2005-05-11 GT GT200500111A patent/GT200500111A/en unknown
- 2005-05-11 CN CNA200580015046XA patent/CN1950359A/en active Pending
- 2005-05-11 KR KR1020067023661A patent/KR20070011483A/en not_active Withdrawn
- 2005-05-11 AR ARP050101914A patent/AR049274A1/en not_active Application Discontinuation
- 2005-05-11 CA CA002566213A patent/CA2566213A1/en not_active Abandoned
- 2005-05-12 PA PA20058633101A patent/PA8633101A1/en unknown
- 2005-05-12 SV SV2005002111A patent/SV2006002111A/en not_active Application Discontinuation
- 2005-05-12 UY UY28897A patent/UY28897A1/en unknown
- 2005-05-12 TW TW094115316A patent/TW200605881A/en unknown
-
2006
- 2006-10-18 TN TNP2006000338A patent/TNSN06338A1/en unknown
- 2006-10-18 ZA ZA200608712A patent/ZA200608712B/en unknown
- 2006-10-27 MA MA29415A patent/MA28553B1/en unknown
- 2006-11-01 IL IL178992A patent/IL178992A0/en unknown
- 2006-11-10 EC EC2006006992A patent/ECSP066992A/en unknown
- 2006-12-12 NO NO20065719A patent/NO20065719L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| UY28897A1 (en) | 2005-12-30 |
| AR049274A1 (en) | 2006-07-12 |
| MA28553B1 (en) | 2007-04-03 |
| TW200605881A (en) | 2006-02-16 |
| BRPI0511029A (en) | 2007-11-27 |
| AU2005245834A1 (en) | 2005-12-01 |
| SV2006002111A (en) | 2006-01-30 |
| EP1747215A1 (en) | 2007-01-31 |
| RU2006143758A (en) | 2008-06-27 |
| GT200500111A (en) | 2006-05-09 |
| CA2566213A1 (en) | 2005-12-11 |
| IL178992A0 (en) | 2007-03-08 |
| NO20065719L (en) | 2006-12-12 |
| TNSN06338A1 (en) | 2008-02-22 |
| WO2005113544A1 (en) | 2005-12-01 |
| JP2007537266A (en) | 2007-12-20 |
| CN1950359A (en) | 2007-04-18 |
| KR20070011483A (en) | 2007-01-24 |
| MXPA06012870A (en) | 2007-02-15 |
| ZA200608712B (en) | 2008-06-25 |
| PE20060269A1 (en) | 2006-05-11 |
| PA8633101A1 (en) | 2006-01-23 |
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