ECSP066998A - HIRTINA CHIRAL DERIVATIVES FOR THE PREPARATION OF EPOTILONES AND PROCESSES TO PREPARE THEM - Google Patents

HIRTINA CHIRAL DERIVATIVES FOR THE PREPARATION OF EPOTILONES AND PROCESSES TO PREPARE THEM

Info

Publication number
ECSP066998A
ECSP066998A EC2006006998A ECSP066998A ECSP066998A EC SP066998 A ECSP066998 A EC SP066998A EC 2006006998 A EC2006006998 A EC 2006006998A EC SP066998 A ECSP066998 A EC SP066998A EC SP066998 A ECSP066998 A EC SP066998A
Authority
EC
Ecuador
Prior art keywords
hirtina
epotilones
prepare
processes
preparation
Prior art date
Application number
EC2006006998A
Other languages
Spanish (es)
Inventor
Werner Skuballa
Johannes Platzek
Orlin Petrov
Marc Willuhn
Klaus-Dieter Graske
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04090157A external-priority patent/EP1589011A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of ECSP066998A publication Critical patent/ECSP066998A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/36—Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)

Abstract

La invención se relaciona con un proceso para la producción de intermediarios clave, útiles en la síntesis de epotilonas o derivados de epotilona, con determinados compuestos usados para la producción de estos intermediarios clave, y con un proceso para la producción de dichos compuestos. Los intermediarios usados están representados por las fórmulas II y III, donde R se selecciona entre H, alquilo y alquilo sustituido, y X1 es un grupo protector de oxígeno.The invention relates to a process for the production of key intermediates, useful in the synthesis of epothilones or epothilone derivatives, with certain compounds used for the production of these key intermediates, and with a process for the production of said compounds. The intermediates used are represented by formulas II and III, where R is selected from H, alkyl and substituted alkyl, and X1 is an oxygen protecting group.

EC2006006998A 2004-04-22 2006-11-13 HIRTINA CHIRAL DERIVATIVES FOR THE PREPARATION OF EPOTILONES AND PROCESSES TO PREPARE THEM ECSP066998A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04090157A EP1589011A1 (en) 2004-04-22 2004-04-22 Novel chiral heptyne derivates for the preparation of epothilones and processes for their preparation
US56584904P 2004-04-28 2004-04-28

Publications (1)

Publication Number Publication Date
ECSP066998A true ECSP066998A (en) 2006-12-29

Family

ID=35456170

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006998A ECSP066998A (en) 2004-04-22 2006-11-13 HIRTINA CHIRAL DERIVATIVES FOR THE PREPARATION OF EPOTILONES AND PROCESSES TO PREPARE THEM

Country Status (6)

Country Link
KR (1) KR20070027536A (en)
CR (1) CR8697A (en)
EC (1) ECSP066998A (en)
HR (1) HRP20070566T3 (en)
IL (1) IL178113A0 (en)
NO (1) NO20065364L (en)

Also Published As

Publication number Publication date
IL178113A0 (en) 2006-12-31
KR20070027536A (en) 2007-03-09
NO20065364L (en) 2007-01-17
CR8697A (en) 2008-09-01
HRP20070566T3 (en) 2008-01-31

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