ECSP067043A - Derivados de pirrolotriazina útiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogénesis - Google Patents

Derivados de pirrolotriazina útiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogénesis

Info

Publication number
ECSP067043A
ECSP067043A EC2006007043A ECSP067043A ECSP067043A EC SP067043 A ECSP067043 A EC SP067043A EC 2006007043 A EC2006007043 A EC 2006007043A EC SP067043 A ECSP067043 A EC SP067043A EC SP067043 A ECSP067043 A EC SP067043A
Authority
EC
Ecuador
Prior art keywords
angiogenesis
diseases associated
proliferative disorders
pirrolotriazine
derivatives
Prior art date
Application number
EC2006007043A
Other languages
English (en)
Inventor
Harold Clinton Eugene Kluender
Steven Magnuson
Julie A Dixon
Catherine Brennan
Karl Miranda
Brent Chandler
Barton Phillips
Jianmei Fan
Michael Brands
Andrea Mcclure
Benjamin Jones
Wenlang Fu
Donald Bierer
Original Assignee
Bayer Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34971944&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP067043(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp
Publication of ECSP067043A publication Critical patent/ECSP067043A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a nuevos compuestos con estructura de pirrolotriazina, a composiciones farmacéuticas que contienen tales compuestos y al uso de esos compuestos y composiciones para la prevención y/o tratamiento de trastornos hiper-proliferativos y enfermedades asociadas con la angiogénesis.
EC2006007043A 2004-06-03 2006-11-30 Derivados de pirrolotriazina útiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogénesis ECSP067043A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57665204P 2004-06-03 2004-06-03
US62653104P 2004-11-09 2004-11-09

Publications (1)

Publication Number Publication Date
ECSP067043A true ECSP067043A (es) 2006-12-29

Family

ID=34971944

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006007043A ECSP067043A (es) 2004-06-03 2006-11-30 Derivados de pirrolotriazina útiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogénesis

Country Status (30)

Country Link
US (3) US7563791B2 (es)
EP (1) EP1765823B1 (es)
JP (1) JP4958772B2 (es)
KR (1) KR101235602B1 (es)
CN (1) CN1993361B (es)
AR (1) AR049138A1 (es)
AT (1) ATE462708T1 (es)
AU (1) AU2005252217B2 (es)
BR (1) BRPI0510848A (es)
CA (1) CA2569396C (es)
DE (1) DE602005020293D1 (es)
EC (1) ECSP067043A (es)
ES (1) ES2342722T3 (es)
GT (1) GT200500137A (es)
HN (1) HN2005000255A (es)
IL (1) IL179264A0 (es)
MA (1) MA28689B1 (es)
MX (1) MX279139B (es)
MY (1) MY145077A (es)
NO (1) NO20070049L (es)
NZ (1) NZ551742A (es)
PE (1) PE20060243A1 (es)
PH (1) PH12006502386B1 (es)
RU (1) RU2401269C2 (es)
SG (1) SG127661A1 (es)
SV (1) SV2006002134A (es)
TW (1) TW200608979A (es)
UY (1) UY28931A1 (es)
WO (1) WO2005121147A1 (es)
ZA (1) ZA200700011B (es)

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CA2865021C (en) * 2012-02-23 2020-06-30 Bayer Intellectual Property Gmbh Substituted benzothienyl-pyrrolotriazines and uses thereof
BR112016028845B1 (pt) 2014-06-17 2023-04-04 Chiesi Farmaceutici S.P.A. Composto, composição farmacêutica e uso de um composto
US10053465B2 (en) 2015-08-26 2018-08-21 Incyte Corporation Pyrrolopyrimidine derivatives as TAM inhibitors
JP7114076B2 (ja) 2015-12-22 2022-08-08 シャイ・セラピューティクス・エルエルシー がん及び炎症性疾患の処置のための化合物
WO2017152117A1 (en) 2016-03-03 2017-09-08 Cornell University Small molecule ire1-alpha inhibitors
CN114456176B (zh) * 2016-03-28 2024-08-30 因赛特公司 作为tam抑制剂的吡咯并三嗪化合物
WO2018161033A1 (en) * 2017-03-02 2018-09-07 Wright, Adrian Small molecule ire1-alpha inhibitors
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JP7536767B2 (ja) 2018-12-31 2024-08-20 バイオメア フュージョン，インコーポレイテッド メニン－ｍｌｌ相互作用の不可逆的阻害剤
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WO2021057877A1 (zh) * 2019-09-26 2021-04-01 深圳市塔吉瑞生物医药有限公司 取代的芳香稠合环衍生物及其组合物及用途
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KR20240087693A (ko) 2021-08-20 2024-06-19 바이오메아 퓨전, 인크. 암 치료를 위한 비가역적 메닌-mll 억제제인 n-[4-[4-(4-모르폴리닐)-7h-피롤로[2,3-d]피리미딘-6-일]페닐]-4-[[3(r)-[(1-옥소-2-프로펜-1-일)아미노]-1-피페리디닐]메틸]-2-피리딘카르복스아미드의 결정질 형태
TW202430528A (zh) 2023-01-18 2024-08-01 美商拜歐米富士恩股份有限公司 Ｎ－［４－［４－（４－嗎啉基）－７ｈ－吡咯並［２，３－ｄ］嘧啶－６－基］苯基］－４－［［３（ｒ）－［（１－氧代－２－丙烯－１－基）氨基］－１－哌啶基］甲基］－２－吡啶甲醯胺的結晶形式作為ｍｅｎｉｎ－ｍｌｌ相互作用的共價抑制劑

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Also Published As

Publication number Publication date
CA2569396C (en) 2011-12-20
MA28689B1 (fr) 2007-06-01
HK1109141A1 (en) 2008-05-30
CN1993361B (zh) 2010-05-26
CA2569396A1 (en) 2005-12-22
KR101235602B1 (ko) 2013-02-21
KR20070035028A (ko) 2007-03-29
UY28931A1 (es) 2005-12-30
MX279139B (es) 2010-09-21
US20070208013A1 (en) 2007-09-06
MXPA06013457A (es) 2007-03-01
TW200608979A (en) 2006-03-16
EP1765823A1 (en) 2007-03-28
HN2005000255A (es) 2010-09-17
RU2401269C2 (ru) 2010-10-10
US20130225809A1 (en) 2013-08-29
AU2005252217A1 (en) 2005-12-22
SG127661A1 (en) 2007-01-30
NZ551742A (en) 2010-08-27
JP2008501703A (ja) 2008-01-24
ATE462708T1 (de) 2010-04-15
SV2006002134A (es) 2006-10-04
NO20070049L (no) 2007-01-30
JP4958772B2 (ja) 2012-06-20
GT200500137A (es) 2006-05-18
BRPI0510848A (pt) 2007-11-27
DE602005020293D1 (de) 2010-05-12
EP1765823B1 (en) 2010-03-31
AR049138A1 (es) 2006-06-28
MY145077A (en) 2011-12-15
RU2006147237A (ru) 2008-07-20
US20100075958A1 (en) 2010-03-25
ZA200700011B (en) 2008-11-26
US8338595B2 (en) 2012-12-25
AU2005252217B2 (en) 2011-05-12
ES2342722T3 (es) 2010-07-13
IL179264A0 (en) 2007-03-08
US7563791B2 (en) 2009-07-21
WO2005121147A1 (en) 2005-12-22
PE20060243A1 (es) 2006-04-21
CN1993361A (zh) 2007-07-04
PH12006502386B1 (en) 2010-12-23

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