ECSP077381A - Comprimido bicapa - Google Patents
Comprimido bicapaInfo
- Publication number
- ECSP077381A ECSP077381A EC2007007381A ECSP077381A ECSP077381A EC SP077381 A ECSP077381 A EC SP077381A EC 2007007381 A EC2007007381 A EC 2007007381A EC SP077381 A ECSP077381 A EC SP077381A EC SP077381 A ECSP077381 A EC SP077381A
- Authority
- EC
- Ecuador
- Prior art keywords
- bicapa
- compressed
- tablet
- immediate release
- matrix
- Prior art date
Links
- 239000012729 immediate-release (IR) formulation Substances 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 abstract 2
- 102000005862 Angiotensin II Human genes 0.000 abstract 1
- 101800000733 Angiotensin-2 Proteins 0.000 abstract 1
- 239000005537 C09CA07 - Telmisartan Substances 0.000 abstract 1
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 abstract 1
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 abstract 1
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 abstract 1
- 229950006323 angiotensin ii Drugs 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 230000003628 erosive effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 abstract 1
- 229960002855 simvastatin Drugs 0.000 abstract 1
- 229960005187 telmisartan Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un comprimido bicapa comprende una primera capa formulada para la liberación inmediata del antagonista del receptor de angiotensina II telmisartán desde una matriz de disolución de comprimido y una segunda capa formulada para la liberación inmediata del inhibidor de la HMG-CoA reductasa simvastatina desde una matriz de disgregación o erosión de comprimido
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04024239 | 2004-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP077381A true ECSP077381A (es) | 2007-05-30 |
Family
ID=36145644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2007007381A ECSP077381A (es) | 2004-10-12 | 2007-04-11 | Comprimido bicapa |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20060078615A1 (es) |
| EP (1) | EP1802283A2 (es) |
| JP (1) | JP2008515838A (es) |
| KR (1) | KR20070064366A (es) |
| CN (1) | CN101052380A (es) |
| AR (1) | AR052775A1 (es) |
| AU (1) | AU2005293773A1 (es) |
| BR (1) | BRPI0516073A (es) |
| CA (1) | CA2578447A1 (es) |
| EA (1) | EA200700765A1 (es) |
| EC (1) | ECSP077381A (es) |
| IL (1) | IL182455A0 (es) |
| NO (1) | NO20071375L (es) |
| TW (1) | TW200628174A (es) |
| UY (1) | UY29160A1 (es) |
| WO (1) | WO2006040085A2 (es) |
| ZA (1) | ZA200701098B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0322552D0 (en) | 2003-09-26 | 2003-10-29 | Astrazeneca Uk Ltd | Therapeutic treatment |
| US8642083B2 (en) * | 2006-10-30 | 2014-02-04 | Hanall Biopharma Co., Ltd. | Controlled release complex composition comprising angiotensin-II-receptor blockers and HMG-CoA reductase inhibitors |
| WO2008068217A2 (en) * | 2006-12-04 | 2008-06-12 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a coated hmg-coa reductase inhibitor and an inhibitor of the renin-angiotensin system |
| EP1970053A1 (en) * | 2007-03-14 | 2008-09-17 | Boehringer Ingelheim Pharma GmbH & Co. KG | Pharmaceutical composition |
| CN101219120B (zh) * | 2007-12-27 | 2011-02-23 | 江苏万邦生化医药股份有限公司 | 替米沙坦分散片及其制备方法 |
| WO2009120052A1 (es) * | 2008-03-24 | 2009-10-01 | Laboratorios Pisa, S.A. De C.V. | Composición farmacéutica con efecto sinérgico para el tratamiento de hipertensión arterial y dislipidemia |
| KR101209319B1 (ko) | 2008-04-29 | 2012-12-06 | 한올바이오파마주식회사 | 안지오텐신-ⅱ-수용체 차단제를 포함하는 약제학적 제제 |
| WO2010021473A2 (ko) * | 2008-08-19 | 2010-02-25 | 한올제약주식회사 | 약제학적 제제 |
| CZ2008740A3 (cs) * | 2008-11-24 | 2010-01-06 | Zentiva, A.S. | Pevná farmaceutická kompozice s úcinnými látkami atorvastatinem a telmisartanem |
| KR101248804B1 (ko) * | 2010-05-14 | 2013-03-29 | 한미사이언스 주식회사 | HMG-CoA 환원효소 억제제 및 이베살탄을 포함하는 이층정 약제학적 복합제제 |
| AR086675A1 (es) * | 2011-06-14 | 2014-01-15 | Merck Sharp & Dohme | Composiciones farmaceuticas de combinaciones de inhibidores de la dipeptidil peptidasa-4 con simvastatina |
| JP5776776B2 (ja) * | 2011-08-05 | 2015-09-09 | 富士通株式会社 | データ処理システム、およびデータ処理方法 |
| KR101466617B1 (ko) * | 2011-11-17 | 2014-11-28 | 한미약품 주식회사 | 오메가-3 지방산 및 HMG-CoA 환원효소 억제제를 포함하는 안정성이 증가된 경구용 복합 제제 |
| JP6649378B2 (ja) | 2014-07-25 | 2020-02-19 | ローラン・ファーマシューティカルズ | フェンレチニドの固体経口処方物 |
| US10406127B2 (en) | 2014-07-25 | 2019-09-10 | Laurent Pharmaceuticals | Solid oral formulation of fenretinide |
| CN104739833A (zh) * | 2015-02-16 | 2015-07-01 | 江苏欧信医药化工有限公司 | 含替米沙坦和瑞舒伐他汀钙的复方双层片剂及其制备方法 |
| EP3307069B1 (en) | 2015-06-10 | 2021-08-04 | Hackensack University Medical Center | Use of telmisartan to prevent and treat graft versus host disease and other alloimmune and autoimmune diseases |
| KR101883091B1 (ko) * | 2017-01-18 | 2018-07-27 | 아주대학교산학협력단 | 안지오텐신 수용체 차단제 및 HMG-CoA 환원효소 억제제를 유효성분으로 함유하는 이층정 복합제제 및 이의 제조방법 |
| CN112168801A (zh) * | 2020-10-22 | 2021-01-05 | 哈药集团技术中心 | 一种辛伐他汀片的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916595A (en) * | 1997-12-12 | 1999-06-29 | Andrx Pharmaceutials, Inc. | HMG co-reductase inhibitor |
| US6576256B2 (en) * | 2001-08-28 | 2003-06-10 | The Brigham And Women's Hospital, Inc. | Treatment of patients at elevated cardiovascular risk with a combination of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
| BR0215514A (pt) * | 2002-01-16 | 2004-12-21 | Boehringer Ingelheim Pharma | Comprimido farmacêutico de bicamada compreendendo telmisartan e um diurético e preparação deste |
| DE10244681A1 (de) * | 2002-09-24 | 2004-04-08 | Boehringer Ingelheim International Gmbh | Neue feste Telmisartan enthaltende pharmazeutische Formulierungen und deren Herstellung |
| DE10335027A1 (de) * | 2003-07-31 | 2005-02-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Angiotensin II Rezeptor Antagonisten |
| PL376213A1 (en) * | 2003-01-16 | 2005-12-27 | Boehringer Ingelheim International Gmbh | Pharmaceutical combination for the prophylaxis or treatment of cardiovascular, cardiopulmonary, pulmonary or renal diseases |
| US20040265375A1 (en) * | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
-
2005
- 2005-09-28 US US11/236,911 patent/US20060078615A1/en not_active Abandoned
- 2005-10-07 WO PCT/EP2005/010812 patent/WO2006040085A2/en not_active Ceased
- 2005-10-07 EP EP05793773A patent/EP1802283A2/en not_active Withdrawn
- 2005-10-07 CA CA002578447A patent/CA2578447A1/en not_active Abandoned
- 2005-10-07 BR BRPI0516073-1A patent/BRPI0516073A/pt not_active Application Discontinuation
- 2005-10-07 AU AU2005293773A patent/AU2005293773A1/en not_active Abandoned
- 2005-10-07 EA EA200700765A patent/EA200700765A1/ru unknown
- 2005-10-07 KR KR1020077010643A patent/KR20070064366A/ko not_active Withdrawn
- 2005-10-07 JP JP2007535100A patent/JP2008515838A/ja active Pending
- 2005-10-07 CN CNA2005800338290A patent/CN101052380A/zh active Pending
- 2005-10-11 TW TW094135304A patent/TW200628174A/zh unknown
- 2005-10-11 UY UY29160A patent/UY29160A1/es not_active Application Discontinuation
- 2005-10-12 AR ARP050104270A patent/AR052775A1/es unknown
-
2007
- 2007-02-07 ZA ZA200701098A patent/ZA200701098B/xx unknown
- 2007-03-14 NO NO20071375A patent/NO20071375L/no not_active Application Discontinuation
- 2007-04-11 EC EC2007007381A patent/ECSP077381A/es unknown
- 2007-04-11 IL IL182455A patent/IL182455A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200701098B (en) | 2009-06-24 |
| TW200628174A (en) | 2006-08-16 |
| AR052775A1 (es) | 2007-04-04 |
| AU2005293773A1 (en) | 2006-04-20 |
| US20060078615A1 (en) | 2006-04-13 |
| WO2006040085A2 (en) | 2006-04-20 |
| NO20071375L (no) | 2007-05-10 |
| WO2006040085A3 (en) | 2007-03-15 |
| UY29160A1 (es) | 2006-05-31 |
| CA2578447A1 (en) | 2006-04-20 |
| IL182455A0 (en) | 2007-07-24 |
| JP2008515838A (ja) | 2008-05-15 |
| CN101052380A (zh) | 2007-10-10 |
| BRPI0516073A (pt) | 2008-08-19 |
| EP1802283A2 (en) | 2007-07-04 |
| EA200700765A1 (ru) | 2007-10-26 |
| KR20070064366A (ko) | 2007-06-20 |
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