ECSP077649A - Piridazinonilos macrociclicos como inhibidores de serina proteasa de hepatitis c - Google Patents

Piridazinonilos macrociclicos como inhibidores de serina proteasa de hepatitis c

Info

Publication number
ECSP077649A
ECSP077649A EC2007007649A ECSP077649A ECSP077649A EC SP077649 A ECSP077649 A EC SP077649A EC 2007007649 A EC2007007649 A EC 2007007649A EC SP077649 A ECSP077649 A EC SP077649A EC SP077649 A ECSP077649 A EC SP077649A
Authority
EC
Ecuador
Prior art keywords
hepatitis
serine protease
compounds
piridazinonilos
macrociclicos
Prior art date
Application number
EC2007007649A
Other languages
English (en)
Inventor
Or Yat Sun
Zhe Wang
Joel D Moore
Datong Tang
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/832,893 external-priority patent/US7718612B2/en
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of ECSP077649A publication Critical patent/ECSP077649A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compuestos de Fórmula I, o sus sales aceptables para uso farmacéutico, ésteres o prodrogas, que inhiben la actividad de serina proteasa , particularmente la actividad de la NS3-NS4A proteasa del virus de hepatitis C (VHC). En consecuencia, los compuestos de la presente invención interfieren con el ciclo de vida del virus de hepatitis C y también son útiles como agentes antivirales. Composiciones farmacéuticas que comprenden dichos compuestos para su administración a un sujeto afectado por una infección por VHC. Métodos para tratar una infección por VHC en un sujeto administrando una composición farmacéutica que comprende un compuesto de la presente invención.
EC2007007649A 2006-08-04 2007-08-06 Piridazinonilos macrociclicos como inhibidores de serina proteasa de hepatitis c ECSP077649A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49984406A 2006-08-04 2006-08-04
US11/832,893 US7718612B2 (en) 2007-08-02 2007-08-02 Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors

Publications (1)

Publication Number Publication Date
ECSP077649A true ECSP077649A (es) 2008-03-26

Family

ID=39033583

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007007649A ECSP077649A (es) 2006-08-04 2007-08-06 Piridazinonilos macrociclicos como inhibidores de serina proteasa de hepatitis c

Country Status (4)

Country Link
CO (1) CO6020004A1 (es)
EC (1) ECSP077649A (es)
PE (1) PE20080539A1 (es)
WO (1) WO2008019303A2 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
AR057456A1 (es) 2005-07-20 2007-12-05 Merck & Co Inc Inhibidores de la proteasa ns3 del vhc
EA200801050A1 (ru) 2005-10-11 2008-12-30 Интермьюн, Инк. Соединения и способы ингибирования репликации вирусного гепатита с
RU2008152171A (ru) 2006-07-05 2010-08-10 Интермьюн, Инк. (Us) Новые ингибиторы вирусной репликации гепатита с
US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
TW201040181A (en) 2009-04-08 2010-11-16 Idenix Pharmaceuticals Inc Macrocyclic serine protease inhibitors
EP2432318A4 (en) * 2009-05-22 2012-11-21 Sequoia Pharmaceuticals Inc NS3 PROTEASE INHIBITORS OF BIPACROCYCLIC HEPATITIS C VIRUS
US8232246B2 (en) 2009-06-30 2012-07-31 Abbott Laboratories Anti-viral compounds
AR077712A1 (es) 2009-08-05 2011-09-14 Idenix Pharmaceuticals Inc Inhibidores de serina proteasa macrociclica
EA201201031A1 (ru) 2010-01-25 2013-02-28 Энанта Фармасьютиклз, Инк. Ингибиторы вируса гепатита с
US8933110B2 (en) 2010-01-25 2015-01-13 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
KR20140003521A (ko) 2010-12-30 2014-01-09 이난타 파마슈티칼스, 인코포레이티드 페난트리딘 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제
CN103534256B (zh) 2010-12-30 2016-08-10 益安药业 大环丙型肝炎丝氨酸蛋白酶抑制剂
TW201309690A (zh) 2011-02-10 2013-03-01 Idenix Pharmaceuticals Inc 巨環絲胺酸蛋白酶抑制劑，其醫藥組合物及其於治療ｈｃｖ感染之用途
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
JP6154474B2 (ja) 2012-10-19 2017-06-28 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎ウイルス阻害剤
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2914613B1 (en) 2012-11-02 2017-11-22 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2014071007A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2914614B1 (en) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9310374B2 (en) * 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
EP2964664B1 (en) 2013-03-07 2017-01-11 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
WO2017083306A1 (en) 2015-11-09 2017-05-18 R.P. Scherer Technologies, Llc Anti-cd22 antibody-maytansine conjugates and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601709B2 (en) * 2003-02-07 2009-10-13 Enanta Pharmaceuticals, Inc. Macrocyclic hepatitis C serine protease inhibitors
CN1771050A (zh) * 2003-02-07 2006-05-10 益安药业 丙型肝炎丝氨酸蛋白酶的大环抑制剂
US20040180815A1 (en) * 2003-03-07 2004-09-16 Suanne Nakajima Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors

Also Published As

Publication number Publication date
CO6020004A1 (es) 2009-03-31
PE20080539A1 (es) 2008-05-16
WO2008019303A3 (en) 2008-10-30
WO2008019303A2 (en) 2008-02-14

Similar Documents

Publication Publication Date Title
ECSP077648A (es) Tetrazolilos macrociclicos como inhibidores de serina proteasa de hepatitis c
DOP2019000218A (es) Inhibidores de las proteasas de serina del vhc derivados de prolinas macrocíclicas
AR061238A1 (es) Compuestos de oxilmilo macrociclico inhibidores de proteasa de hepatitis c
UY30391A1 (es) Compuesto de oximilo aciclico inhibidores de proteasa de hepatitis c
CO6280441A2 (es) Compuestos que contienen quinoxalina como inhibidores del virus de la hepatitis c
UY30437A1 (es) Quinoxalinil macroceclicos inhibidores de serina proteasa del virus de la hepatitis c
CO6571891A2 (es) Inhibidores del virus de la hepatitis c.
CO2020002980A2 (es) Agentes antivirales contra la hepatitis b.
UY28423A1 (es) Inhibidores de proteasas serinas, en especial proteasa ns3-ns4a del vhc.-
MX2010010276A (es) Compuestos macrociclicos fluorinados como inhibidores del virus de hepatitis c.
UY37997A (es) Agentes antivirales contra la hepatitis b
DOP2013000238A (es) Derivados de nucleosidos 2'-sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales
ECSP088258A (es) Inhibidores de serina proteasas
UY28500A1 (es) Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc.
MX2010006210A (es) Inhibidores de serina proteasa de hcv de tripeptido fluorado.
MX2010006518A (es) Inhibidores de serina proteasa de hepatitis c de oximil macrociclica.
MX2011012155A (es) Compuestos macrociclicos como inhibidores del virus de hepatitis c.
WO2008019303A3 (en) Pyridazinonyl macrocyclic hepatitis c serine protease inhibitors
MX2010008108A (es) Inhibidores de proteasa de serina de tripéptido de virus de hepatitis c (hcv) que contienen heteroarilo.
TH139657A (th) สารยับยั้ง hcv เซอรีนโปรติเอสที่ให้มาโครไซคลิกโพรลีน