ECSP077981A - Formas polimórficas del éster etílico del ácido 3-[(2-{[4-(hexiloxicarbonilamino- imino-metil)-fenilamino]-metil}-1-metil-1h-bencimidazol-5-carbonil)-piridin-2-il- amino]-propiónico - Google Patents

Formas polimórficas del éster etílico del ácido 3-[(2-{[4-(hexiloxicarbonilamino- imino-metil)-fenilamino]-metil}-1-metil-1h-bencimidazol-5-carbonil)-piridin-2-il- amino]-propiónico

Info

Publication number
ECSP077981A
ECSP077981A EC2007007981A ECSP077981A ECSP077981A EC SP077981 A ECSP077981 A EC SP077981A EC 2007007981 A EC2007007981 A EC 2007007981A EC SP077981 A ECSP077981 A EC SP077981A EC SP077981 A ECSP077981 A EC SP077981A
Authority
EC
Ecuador
Prior art keywords
methyl
imino
propionic
amino
ethyl
Prior art date
Application number
EC2007007981A
Other languages
English (en)
Inventor
Peter Sieger
Rainer Sobotta
Rolf Schmid
Norbert Hauel
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36812978&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP077981(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of ECSP077981A publication Critical patent/ECSP077981A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La invención se refiere a nuevas formas polimorfas del principio activo éster etílico del ácido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}-1-metil- 1H-bencimidazol-5-carbonil)-piridin-2-il-amino]-propiónico, a su preparación y a su utilización como medicamentos.
EC2007007981A 2005-06-04 2007-12-05 Formas polimórficas del éster etílico del ácido 3-[(2-{[4-(hexiloxicarbonilamino- imino-metil)-fenilamino]-metil}-1-metil-1h-bencimidazol-5-carbonil)-piridin-2-il- amino]-propiónico ECSP077981A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005025728A DE102005025728A1 (de) 2005-06-04 2005-06-04 Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-Propionsäure-ethylester

Publications (1)

Publication Number Publication Date
ECSP077981A true ECSP077981A (es) 2008-01-23

Family

ID=36812978

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007007981A ECSP077981A (es) 2005-06-04 2007-12-05 Formas polimórficas del éster etílico del ácido 3-[(2-{[4-(hexiloxicarbonilamino- imino-metil)-fenilamino]-metil}-1-metil-1h-bencimidazol-5-carbonil)-piridin-2-il- amino]-propiónico

Country Status (22)

Country Link
US (1) US20060276513A1 (es)
EP (3) EP2305665A1 (es)
JP (1) JP2008545734A (es)
KR (1) KR20080021763A (es)
CN (1) CN101189224B (es)
AR (1) AR054278A1 (es)
AU (1) AU2006256778A1 (es)
BR (1) BRPI0611099A2 (es)
CA (1) CA2609583A1 (es)
DE (1) DE102005025728A1 (es)
EA (1) EA014082B1 (es)
EC (1) ECSP077981A (es)
IL (1) IL187845A0 (es)
MX (1) MX2007014892A (es)
NO (1) NO20075862L (es)
NZ (1) NZ564621A (es)
PE (1) PE20070082A1 (es)
TW (1) TW200716107A (es)
UA (1) UA92349C2 (es)
UY (1) UY29575A1 (es)
WO (1) WO2006131491A1 (es)
ZA (1) ZA200709715B (es)

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DE10339862A1 (de) * 2003-08-29 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel
DE102006054005A1 (de) * 2006-11-16 2008-05-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester
RU2010143901A (ru) * 2008-03-28 2012-05-10 Бёрингер Ингельхайм Интернациональ Гмбх (De) Способ получения композиций дабигатрана для перорального введения
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PE20110431A1 (es) 2008-11-11 2011-07-13 Boehringer Ingelheim Int Etexilato de dabigatran o una sal del mismo
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EP2545044A1 (en) 2010-03-08 2013-01-16 ratiopharm GmbH Dabigatran etexilate-containing pharmaceutical composition
WO2012027543A1 (en) 2010-08-25 2012-03-01 Teva Pharmaceuticals Usa, Inc. Solid state forms of dabigatran etexilate, dabigatran etexilate mesylate and processes for preparation thereof
US9174609B2 (en) 2011-04-21 2015-11-03 Pylon Manufacturing Corp. Wiper blade with cover
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WO2012162492A1 (en) 2011-05-24 2012-11-29 Teva Pharmaceutical Industries Ltd. Compressed core comprising organic acids for a pharmaceutical composition
EP2610251A1 (en) * 2011-12-29 2013-07-03 Zaklady Farmaceutyczne Polpharma SA Novel polymorphic forms of dabigatran etexilate and process for the preparation thereof
US9212166B2 (en) 2012-01-20 2015-12-15 Cadila Healthcare Limited Process for the preparation of dabigatran etexilate mesylate and polymorphs of intermediates thereof
WO2013124749A1 (en) * 2012-02-20 2013-08-29 Alembic Pharmaceuticals Limited Novel polymorph of dabigatran etexilate
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WO2014020546A2 (en) 2012-07-31 2014-02-06 Ranbaxy Laboratories Limited Crystalline forms of dabigatran etexilate and process for their preparation
CA2881947A1 (en) 2012-08-31 2014-03-06 Ranbaxy Laboratories Limited Process for the preparation of crystalline form i of methanesulfonate salt of dabigatran etexilate
CN103664881A (zh) * 2012-09-20 2014-03-26 天津药物研究院 结晶变体形态b的达比加群酯及其制备方法和用途
US20150225370A1 (en) 2012-09-28 2015-08-13 Ranbaxy Laboratories Limited Process for the preparation of dabigatran etexilate or pharmaceutically acceptable salt thereof
WO2014049585A2 (en) 2012-09-28 2014-04-03 Ranbaxy Laboratories Limited Process for the preparation of dabigatran etexilate or pharmaceutically acceptable salt thereof
EP2722033A1 (en) * 2012-10-19 2014-04-23 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical Compositions of Dabigatran Free Base
CN103788063B (zh) * 2012-10-29 2016-01-20 天津药物研究院 四水合达比加群酯晶体及其制备方法和药物用途
CN103864756B (zh) * 2012-12-11 2018-06-15 四川海思科制药有限公司 丁二磺酸达比加群酯及其制备方法和用途
WO2014178017A1 (en) 2013-04-30 2014-11-06 Ranbaxy Laboratories Limited Dabigatran etexilate impurity, process of its preparation, and its use as a reference standard
WO2015124764A1 (en) 2014-02-24 2015-08-27 Erregierre S.P.A. Synthesis process of dabigatran etexilate mesylate, intermediates of the process and novel polymorph of dabigatran etexilate
IN2014MU00675A (es) 2014-02-26 2015-10-23 Megafine Pharma P Ltd
CN104892574A (zh) * 2014-03-04 2015-09-09 浙江海正药业股份有限公司 达比加群酯甲磺酸盐的晶型及其制备方法和用途
CN104974137A (zh) * 2014-04-04 2015-10-14 江苏天士力帝益药业有限公司 达比加群酯甲磺酸盐新晶型及其制备方法
WO2017037743A2 (en) * 2015-09-03 2017-03-09 Sun Pharmaceutical Industries Limited Dabigatran etexilate 1,4-butanedisulfonate salt and its crystal form
CN105859686B (zh) 2016-05-24 2021-10-08 浙江华海药业股份有限公司 一种达比加群酯游离碱的精制方法
CN106349221A (zh) * 2016-08-29 2017-01-25 常州市阳光药业有限公司 高纯度达比加群酯的制备方法
CN107778291A (zh) * 2016-08-31 2018-03-09 亚宝药业集团股份有限公司 一种甲磺酸达比加群酯晶型ⅱ的制备方法
JP2020193184A (ja) * 2019-05-30 2020-12-03 ダイト株式会社 ダビガトランエテキシラートメタンスルホン酸塩の形態ｉの製造方法

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Also Published As

Publication number Publication date
JP2008545734A (ja) 2008-12-18
AU2006256778A8 (en) 2008-03-13
MX2007014892A (es) 2008-04-17
EP1891046A1 (de) 2008-02-27
EP2088146A2 (de) 2009-08-12
US20060276513A1 (en) 2006-12-07
KR20080021763A (ko) 2008-03-07
CN101189224A (zh) 2008-05-28
UA92349C2 (ru) 2010-10-25
ZA200709715B (en) 2008-10-29
EA014082B1 (ru) 2010-08-30
EA200702541A1 (ru) 2008-06-30
AU2006256778A1 (en) 2006-12-14
TW200716107A (en) 2007-05-01
NZ564621A (en) 2011-03-31
WO2006131491A1 (de) 2006-12-14
NO20075862L (no) 2008-02-26
CN101189224B (zh) 2012-03-28
IL187845A0 (en) 2008-03-20
EP2305665A1 (de) 2011-04-06
CA2609583A1 (en) 2006-12-14
PE20070082A1 (es) 2007-01-16
WO2006131491A8 (de) 2007-12-27
BRPI0611099A2 (pt) 2010-08-10
DE102005025728A1 (de) 2006-12-07
UY29575A1 (es) 2006-12-29
AR054278A1 (es) 2007-06-13
EP2088146A3 (de) 2009-10-28

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