ECSP077996A - DERIVATIVES OF PIRIDONA TO MODULATE THE SYSTEM OF STRESS ACTIVATED KINASE PROTEIN - Google Patents

DERIVATIVES OF PIRIDONA TO MODULATE THE SYSTEM OF STRESS ACTIVATED KINASE PROTEIN

Info

Publication number
ECSP077996A
ECSP077996A EC2007007996A ECSP077996A ECSP077996A EC SP077996 A ECSP077996 A EC SP077996A EC 2007007996 A EC2007007996 A EC 2007007996A EC SP077996 A ECSP077996 A EC SP077996A EC SP077996 A ECSP077996 A EC SP077996A
Authority
EC
Ecuador
Prior art keywords
derivatives
modulate
piridona
sapk
kinase protein
Prior art date
Application number
EC2007007996A
Other languages
Spanish (es)
Inventor
Lawrence M Blatt
Scott D Seiwert
Leonid Beigelman
Ramachandran Radhakrishnan
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of ECSP077996A publication Critical patent/ECSP077996A/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a métodos para modular un sistema de proteína cinasa activada por estrés (SAPK) con un compuesto activo, en donde el compuesto activo exhibe baja potencia para inhibición de al menos, una p38 MAPK; y en donde el contacto se conduce a una concentración que modula el SAPK que está a una concentración inhibitoria de bajo porcentaje, para inhibición de al menos, una p38 MAPK por el compuesto. También se describen derivados de pirfenidona. Estos derivados pueden modular un sistema de proteína cinasa activada por estrés (SAPK).The present invention relates to methods for modulating a stress-activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one MAP38 p38; and wherein the contact is conducted at a concentration that modulates the SAPK which is at a low percentage inhibitory concentration, for inhibition of at least one p38 MAPK per compound. Pirfenidone derivatives are also described. These derivatives can modulate a stress-activated protein kinase system (SAPK).

EC2007007996A 2005-05-10 2007-12-10 DERIVATIVES OF PIRIDONA TO MODULATE THE SYSTEM OF STRESS ACTIVATED KINASE PROTEIN ECSP077996A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67947105P 2005-05-10 2005-05-10

Publications (1)

Publication Number Publication Date
ECSP077996A true ECSP077996A (en) 2008-02-20

Family

ID=39921062

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007007996A ECSP077996A (en) 2005-05-10 2007-12-10 DERIVATIVES OF PIRIDONA TO MODULATE THE SYSTEM OF STRESS ACTIVATED KINASE PROTEIN

Country Status (3)

Country Link
CN (1) CN101237869A (en)
EC (1) ECSP077996A (en)
ZA (1) ZA200709593B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101874801A (en) * 2009-04-29 2010-11-03 中南大学 Use of pyridone compounds in the preparation of drugs for the treatment of diabetic nephropathy
CN102149682B (en) * 2009-05-25 2012-12-05 中南大学 Preparation method and use of 1-(substituted aryl)-5-trifluoromethyl-2-(1H)pyridone compound and its salt
EP2474533B1 (en) 2009-05-25 2015-02-25 Central South University Preparation of 1-(substituted benzyl)-5-trifluoromethyl-2-(1h)pyridone compounds and salts thereof and their applications
RU2692485C2 (en) * 2014-04-02 2019-06-25 Интермьюн, Инк. Antifibrous pyridinones
CN105884680B (en) * 2016-06-16 2019-06-25 杨若一 Pirfenidone derivative and preparation method thereof and purposes
CN106045971B (en) * 2016-06-16 2018-12-21 杨若一 Pirfenidone derivative and preparation method thereof
WO2021057599A1 (en) * 2019-09-26 2021-04-01 深圳先进技术研究院 Application of pirfenidone in preparing medicament for preventing and treating rheumatoid arthritis
CN112986065B (en) * 2021-02-08 2021-08-31 杭州同创医学检验实验室有限公司 Whole blood quality control product for hematology analyzer and preparation method thereof
CN114716365B (en) * 2022-01-04 2024-03-01 大连理工大学 Application of N-substituted phenyl-2-pyridone compound or pharmaceutically acceptable salt thereof in treatment of pulmonary fibrosis
WO2024235145A1 (en) * 2023-05-12 2024-11-21 大连理工大学 Preparation and use of n-substituted phenyl-2-pyridone and endoperoxide
WO2026077440A1 (en) * 2024-10-12 2026-04-16 Beijing Continent Pharmaceuticals Co., Ltd. Compositions and methods for preventing and treating chronic renal failure

Also Published As

Publication number Publication date
ZA200709593B (en) 2009-06-24
CN101237869A (en) 2008-08-06

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