ECSP084358A - NUEVAS FORMAS SÓLIDAS DE LA MESOPROGESTINA 11ß-[4E-(HIDROXIIMINOMETIL)-FENIL]- 17ALFA-METOXIMETIL-17ß-METOXI-ESTRA-4,9-DIEN-3-ONA - Google Patents

NUEVAS FORMAS SÓLIDAS DE LA MESOPROGESTINA 11ß-[4E-(HIDROXIIMINOMETIL)-FENIL]- 17ALFA-METOXIMETIL-17ß-METOXI-ESTRA-4,9-DIEN-3-ONA

Info

Publication number
ECSP084358A
ECSP084358A EC2008004358A ECSP084358A ECSP084358A EC SP084358 A ECSP084358 A EC SP084358A EC 2008004358 A EC2008004358 A EC 2008004358A EC SP084358 A ECSP084358 A EC SP084358A EC SP084358 A ECSP084358 A EC SP084358A
Authority
EC
Ecuador
Prior art keywords
solid forms
estra
dien
mesoprogestine
hydroxyiminometil
Prior art date
Application number
EC2008004358A
Other languages
English (en)
Inventor
Detlef Grawe
Uwe Mueller
Peter Hoesel
Gabriele Winter
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of ECSP084358A publication Critical patent/ECSP084358A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

El invento se refiere a las nuevas formas sólidas de la mesoprogestina 11 -[4E-(hidroxiiminometil)-fenil]-17 -metoxi-metil-17 -metoxi-estra-4,9-dien-3-ona (oxima J 867), especialmente a una forma extrapura y estable, amorfa o extracristalina (forma no solvatada (no solvato)/no hidrato), del compuesto J 867, a un método para su preparación y a su uso en composiciones farmacéuticas.Las nuevas formas sólidas se caracterizan especialmente por su alta estabilidad. Estas formas sólidas de la oxima J867 pueden utilizarse especialmente en el control de la fertilidad y en la terapia de reemplazo hormonal.
EC2008004358A 2000-05-23 2008-10-22 NUEVAS FORMAS SÓLIDAS DE LA MESOPROGESTINA 11ß-[4E-(HIDROXIIMINOMETIL)-FENIL]- 17ALFA-METOXIMETIL-17ß-METOXI-ESTRA-4,9-DIEN-3-ONA ECSP084358A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00110887A EP1157996A1 (de) 2000-05-23 2000-05-23 Neue Festkörperformen des Mesoprogestins 11Beta-[4E-(Hydroxyiminomethyl)-phenyl]-17Alpha-methoxymethyl-17Beta-methoxy-estra-4,9-dien-3-on

Publications (1)

Publication Number Publication Date
ECSP084358A true ECSP084358A (es) 2008-11-27

Family

ID=8168805

Family Applications (2)

Application Number Title Priority Date Filing Date
EC2002004358A ECSP024358A (es) 2000-05-23 2002-11-22 Nuevas fomas solidas de la meso´rogestina 11beta(4e-hidroxiiminometil)-fenil) 17 alfa-metoximetil-17 beta-metoxi-estra-4,9 -dien-3-ona
EC2008004358A ECSP084358A (es) 2000-05-23 2008-10-22 NUEVAS FORMAS SÓLIDAS DE LA MESOPROGESTINA 11ß-[4E-(HIDROXIIMINOMETIL)-FENIL]- 17ALFA-METOXIMETIL-17ß-METOXI-ESTRA-4,9-DIEN-3-ONA

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EC2002004358A ECSP024358A (es) 2000-05-23 2002-11-22 Nuevas fomas solidas de la meso´rogestina 11beta(4e-hidroxiiminometil)-fenil) 17 alfa-metoximetil-17 beta-metoxi-estra-4,9 -dien-3-ona

Country Status (30)

Country Link
US (1) US7799770B2 (es)
EP (3) EP1157996A1 (es)
JP (1) JP2003534350A (es)
KR (1) KR100553292B1 (es)
CN (1) CN100384867C (es)
AT (1) ATE397617T1 (es)
AU (2) AU2001256344B2 (es)
BG (1) BG65968B1 (es)
BR (1) BR0111058A (es)
CA (1) CA2409869C (es)
CZ (1) CZ2003620A3 (es)
DE (1) DE50114012D1 (es)
DK (1) DK1292607T3 (es)
EA (1) EA005623B1 (es)
EC (2) ECSP024358A (es)
ES (1) ES2307613T3 (es)
HR (2) HRP20080423A2 (es)
HU (1) HUP0301956A3 (es)
IL (2) IL152868A0 (es)
ME (1) MEP15608A (es)
MX (1) MXPA02011524A (es)
NO (1) NO327004B1 (es)
NZ (1) NZ522768A (es)
PL (1) PL358789A1 (es)
PT (1) PT1292607E (es)
RS (1) RS50493B (es)
SK (1) SK2922003A3 (es)
UA (1) UA73988C2 (es)
WO (1) WO2001090137A2 (es)
ZA (1) ZA200209322B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10218109A1 (de) * 2002-04-23 2003-11-20 Jenapharm Gmbh Verfahren zum Herstellen von Kristallen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen
DE10218107A1 (de) * 2002-04-23 2003-11-20 Jenapharm Gmbh Verfahren zum Herstellen von Kristallen von Steroiden, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen
WO2006078731A2 (en) * 2005-01-18 2006-07-27 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Amorphous and crystalline forms of dorzolamide hydrochloride and processes of making same
US20090054387A1 (en) * 2006-04-18 2009-02-26 Detlef Grawe Method for preparing 4-[17beta-methoxy-17alpha-methoxymethyl-3-oxestra-4,9-dien-11beta-yl]benzaldehyde (E)-oxime (asoprisnil)
DE102006018888A1 (de) * 2006-04-18 2007-10-25 Bayer Schering Pharma Ag Verfahren zur Herstellung von 4-[17beta-Methoxy-17alpha-methoxymethyl-3-oxoestra-4,9-dien-11beta-yl]benzaldehyd-(E)-oxims (Asoprisnil)
EP1862468A1 (de) * 2006-06-02 2007-12-05 Bayer Schering Pharma Aktiengesellschaft Kristallines 11beta-(4-Acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-on
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102010007722A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007719A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332283A1 (de) * 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19610667C2 (de) * 1996-03-08 1998-04-09 Schering Ag (Z)-11ß-[4-(Dimethylamino)phenyl]17ß-hydroxy-17alpha-(3-hydroxy-1-propenyl)estr-4-en-3-on als kristallines Ansolvat
AU6335600A (en) * 1999-07-29 2001-02-19 Eli Lilly And Company A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho yphenyl)benzo[b]thiophene hydrochloride

Also Published As

Publication number Publication date
US7799770B2 (en) 2010-09-21
RS50493B (sr) 2010-03-02
ECSP024358A (es) 2003-03-31
YU88702A (sh) 2006-01-16
EP1862469A2 (de) 2007-12-05
DK1292607T3 (da) 2008-10-13
BG65968B1 (bg) 2010-07-30
HUP0301956A3 (en) 2010-03-29
SK2922003A3 (en) 2003-08-05
EA200201192A1 (ru) 2003-06-26
NO20025613L (no) 2002-11-22
EP1292607B1 (de) 2008-06-04
ATE397617T1 (de) 2008-06-15
KR100553292B1 (ko) 2006-02-22
HRP20021032B1 (hr) 2008-09-30
PL358789A1 (en) 2004-08-23
CN100384867C (zh) 2008-04-30
ZA200209322B (en) 2005-03-10
MEP15608A (en) 2010-06-10
NZ522768A (en) 2005-03-24
JP2003534350A (ja) 2003-11-18
NO20025613D0 (no) 2002-11-22
ES2307613T3 (es) 2008-12-01
WO2001090137A3 (de) 2002-04-04
DE50114012D1 (en) 2008-07-17
CN1430624A (zh) 2003-07-16
CZ2003620A3 (cs) 2003-08-13
CA2409869A1 (en) 2002-11-20
AU5634401A (en) 2001-12-03
UA73988C2 (en) 2005-10-17
EP1292607A2 (de) 2003-03-19
MXPA02011524A (es) 2004-09-10
IL152868A0 (en) 2003-06-24
EA005623B1 (ru) 2005-04-28
PT1292607E (pt) 2008-09-15
HRP20021032A2 (en) 2005-02-28
US20040006241A1 (en) 2004-01-08
IL152868A (en) 2009-08-03
AU2001256344B8 (en) 2001-12-03
HUP0301956A2 (hu) 2003-09-29
KR20030028742A (ko) 2003-04-10
WO2001090137A2 (de) 2001-11-29
CA2409869C (en) 2009-02-03
NO327004B1 (no) 2009-04-06
BR0111058A (pt) 2003-04-15
EP1157996A1 (de) 2001-11-28
HRP20080423A2 (en) 2008-10-31
AU2001256344B2 (en) 2007-01-25
BG107557A (bg) 2004-01-30

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