ECSP088081A - Detección de un antigeno diana independientemente de la presencia o ausencia de un anticuerpo terapéutico correspondiente - Google Patents

Detección de un antigeno diana independientemente de la presencia o ausencia de un anticuerpo terapéutico correspondiente

Info

Publication number
ECSP088081A
ECSP088081A EC2008008081A ECSP088081A ECSP088081A EC SP088081 A ECSP088081 A EC SP088081A EC 2008008081 A EC2008008081 A EC 2008008081A EC SP088081 A ECSP088081 A EC SP088081A EC SP088081 A ECSP088081 A EC SP088081A
Authority
EC
Ecuador
Prior art keywords
therapeutic antibody
detection
diana
ancient
absence
Prior art date
Application number
EC2008008081A
Other languages
English (en)
Inventor
Helmut Lenz
Werner Scheuer
Martina Thier
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ECSP088081A publication Critical patent/ECSP088081A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención está relacionada con el campo de los anticuerpos terapéuticos. La invención especialmente está relacionada con un método para la detección del antígeno diana de un anticuerpo terapéutico en una muestra que consiste en los siguientes pasos: a) proporcionar la muestra a analizar, b) incubar dicha muestra con dicho anticuerpo terapéutico bajo las condiciones apropiadas para unir dicho anticuerpo terapéutico a dicho antígeno diana, de manera que se forma un complejo de antígeno diana-anticuerpo terapéutico y c) detectar el complejo formado en (b).
EC2008008081A 2005-07-06 2008-01-04 Detección de un antigeno diana independientemente de la presencia o ausencia de un anticuerpo terapéutico correspondiente ECSP088081A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05014618 2005-07-06
EP06004447 2006-03-06

Publications (1)

Publication Number Publication Date
ECSP088081A true ECSP088081A (es) 2008-02-20

Family

ID=36922121

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008081A ECSP088081A (es) 2005-07-06 2008-01-04 Detección de un antigeno diana independientemente de la presencia o ausencia de un anticuerpo terapéutico correspondiente

Country Status (19)

Country Link
US (1) US20070009976A1 (es)
EP (2) EP1902315A1 (es)
JP (1) JP2008545145A (es)
KR (1) KR20080016939A (es)
AR (1) AR053948A1 (es)
AU (1) AU2006265275A1 (es)
BR (1) BRPI0612591A2 (es)
CA (1) CA2613187A1 (es)
CR (1) CR9635A (es)
EC (1) ECSP088081A (es)
IL (1) IL188317A0 (es)
MA (1) MA29730B1 (es)
MX (1) MX2008000277A (es)
MY (1) MY157955A (es)
NO (1) NO20076662L (es)
NZ (1) NZ564471A (es)
RU (1) RU2008103608A (es)
TW (1) TWI312864B (es)
WO (1) WO2007003420A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2407556C (en) * 2000-05-19 2011-06-21 Genentech, Inc. Gene detection assay for improving the likelihood of an effective response to an erbb antagonist cancer therapy
DK1771482T3 (da) * 2004-07-22 2014-10-20 Genentech Inc HER2-antistofsammensætning
WO2006039486A2 (en) 2004-10-01 2006-04-13 The Board Of Trustees Of The Leland Stanford Junior University Imaging arrangements and methods therefor
JO3000B1 (ar) * 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
EP1850874B1 (en) 2005-02-23 2013-10-16 Genentech, Inc. Extending time to disease progression or survival in ovarian cancer patients using pertuzumab
PE20070207A1 (es) * 2005-07-22 2007-03-09 Genentech Inc Tratamiento combinado de los tumores que expresan el her
WO2007092581A2 (en) 2006-02-07 2007-08-16 The Board Of Trustees Of The Leland Stanford Junior University Correction of optical aberrations
US8358354B2 (en) 2009-01-26 2013-01-22 The Board Of Trustees Of The Leland Stanford Junior University Correction of optical abberations
SI2132573T1 (sl) 2007-03-02 2014-07-31 Genentech, Inc. Napovedovanje odziva na inhibitor dimerizacije HER na osnovi nizke ekspresije HER3
TWI472339B (zh) 2008-01-30 2015-02-11 Genentech Inc 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
IL301603A (en) 2011-10-14 2023-05-01 Genentech Inc Pertuzumab, trastuzumab, docetaxel and carboplatin for use in the preoperative treatment of a patient
KR101327542B1 (ko) * 2012-03-15 2013-11-08 광주과학기술원 양자점 기반의 경쟁 면역분석법 및 다중 유세포 분석법을 이용한 시료 중 오염물질의 검출 방법
AU2012232949B2 (en) * 2012-09-28 2014-07-03 Willowtree Holdings Pty Ltd Temporary bulkhead
MX368259B (es) 2013-04-16 2019-09-25 Genentech Inc Variantes de pertuzumab y su evaluacion.
KR20160141857A (ko) 2014-04-25 2016-12-09 제넨테크, 인크. 트라스투주맙-mcc-dm1 및 퍼투주맙을 이용하는 초기 유방암의 치료방법
WO2016196373A2 (en) 2015-05-30 2016-12-08 Genentech, Inc. Methods of treating her2-positive metastatic breast cancer
WO2017087280A1 (en) 2015-11-16 2017-05-26 Genentech, Inc. Methods of treating her2-positive cancer
EP3562844A1 (en) 2016-12-28 2019-11-06 Genentech, Inc. Treatment of advanced her2 expressing cancer
TW202508629A (zh) 2017-01-17 2025-03-01 美商建南德克公司 皮下her2抗體調配物
PT3589661T (pt) 2017-03-02 2024-01-29 Genentech Inc Tratamento com adjuvante de cancro da mama positivo para her2
WO2018200505A1 (en) 2017-04-24 2018-11-01 Genentech, Inc. Erbb2/her2 mutations in the transmbrane or juxtamembrane domain
JP2023532122A (ja) 2020-06-29 2023-07-26 ジェネンテック， インコーポレイテッド ペルツズマブにトラスツズマブを加えた固定用量配合剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2095818B (en) 1981-03-27 1985-10-02 Exxon Research Engineering Co Staged adsorption/resorption heat pump
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP1400536A1 (en) * 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
AU4025193A (en) 1992-04-08 1993-11-18 Cetus Oncology Corporation Humanized C-erbB-2 specific antibodies
KR20060079258A (ko) 1996-10-18 2006-07-05 제넨테크, 인크. 항-ＥｒｂＢ２ 항체
JP4424987B2 (ja) * 2001-09-20 2010-03-03 ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム Ｅｌｉｓａアッセイを用いた循環する治療抗体、抗原および抗原／抗体複合体の測定
WO2004008099A2 (en) * 2002-07-15 2004-01-22 Genentech, Inc. METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES

Also Published As

Publication number Publication date
RU2008103608A (ru) 2009-08-20
JP2008545145A (ja) 2008-12-11
EP1902315A1 (en) 2008-03-26
IL188317A0 (en) 2008-04-13
BRPI0612591A2 (pt) 2010-11-23
MX2008000277A (es) 2008-03-24
KR20080016939A (ko) 2008-02-22
MA29730B1 (fr) 2008-09-01
NO20076662L (no) 2008-04-03
EP2194380A3 (en) 2010-07-14
TW200741203A (en) 2007-11-01
TWI312864B (en) 2009-08-01
NZ564471A (en) 2010-04-30
MY157955A (en) 2016-08-30
CR9635A (es) 2008-02-20
AR053948A1 (es) 2007-05-23
WO2007003420A1 (en) 2007-01-11
AU2006265275A1 (en) 2007-01-11
CA2613187A1 (en) 2007-01-11
EP2194380A2 (en) 2010-06-09
US20070009976A1 (en) 2007-01-11

Similar Documents

Publication Publication Date Title
ECSP088081A (es) Detección de un antigeno diana independientemente de la presencia o ausencia de un anticuerpo terapéutico correspondiente
ES2528321T3 (es) Detección de a-fucosilación en anticuerpos
EP4273551A3 (en) Multiplexed total antibody and antibody-conjugated drug quantification assay
EP4249605A3 (en) Methods for analyte detection
MX2015012823A (es) Ensayo de combinacion de antigeno-anticuerpo del virus de la hepatitis c (vhc) y metodos y composiciones para usarlo.
WO2013068374A3 (en) Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment
WO2013068373A3 (en) Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients not undergoing statin treatment
NZ609824A (en) Immunochromatography devices, methods and kits
MX358772B (es) Metodo para detectar cancer.
MX2015013596A (es) Metodos, dispositivos y sistemas para analisis de muestras.
MX2019002918A (es) Biomarcadores de metabolitos para enfermedades asociadas con el sistema de activacion por contacto.
BR112018007842A2 (pt) imunoensaio para a detecção de cininogênio clivado de alto peso molecular, método, anticorpo isolado, kit para detectar um cininogênio de alto peso molecular clivado (hmwk)
TW200801202A (en) Alpha-enolase specific antibody and method of use
DK1989544T3 (da) T-celle-testmetode
BR112018017336A2 (pt) método in vitro para detectar um anticorpo para p53 (anticorpo anti-p53) em uma amostra e polipeptídeo de fusão
WO2015077382A3 (en) Combined cytology and molecular testing for early detection of esophageal adenocarcinoma
PE20220004A1 (es) Anticuerpos monoclonales especificos para el antigeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, utiles para la deteccion y el diagnostico de la infeccion causada por vrsh
MX2009012048A (es) Eliminacion de interferencia en inmunoensayos ocasionada por anticuerpos de anti-carbohidrato.
WO2011008831A3 (en) Mass tags for spectrometric analysis of immunoglobulins
EA201692071A1 (ru) Иммуноанализ и антитела для обнаружения хромогранина а
PE20130526A1 (es) Componentes de la pared de celulas de levadura y deteccion de los mismos
EA201400571A1 (ru) Специфичные к трансресвератролу антитела и их применение
EA201691168A1 (ru) Способы исследования бета-глюкана
ES2527703B1 (es) Inmunosensor electroquímico para la determinación cuantitativa de la micotoxina fb1
FR2968767B1 (fr) Procede et coffret pour le diagnostic in vitro du cancer de la prostate