ECSP088172A - Metodos para tratar la epileptogenesis - Google Patents

Metodos para tratar la epileptogenesis

Info

Publication number
ECSP088172A
ECSP088172A EC2008008172A ECSP088172A ECSP088172A EC SP088172 A ECSP088172 A EC SP088172A EC 2008008172 A EC2008008172 A EC 2008008172A EC SP088172 A ECSP088172 A EC SP088172A EC SP088172 A ECSP088172 A EC SP088172A
Authority
EC
Ecuador
Prior art keywords
group
phenyl
alkyl
methods
subject
Prior art date
Application number
EC2008008172A
Other languages
English (en)
Inventor
Boyu Zhao
Roy E Twyman
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37637731&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP088172(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP088172A publication Critical patent/ECSP088172A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Esta invención está dirigida a métodos para prevenir, tratar, invertir, inhibir o detener la epileptogénesis en un sujeto, que comprende administrar al sujeto en necesidad del mismo, una cantidad terapéuticamente efectiva de un compuesto seleccionado del grupo que consiste en la Fórmula (I) y la Fórmula (II), o una sal o éster farmacéuticamente aceptable del mismo:en donde el fenilo está sustituido en X con uno a cinco átomos de halógeno, seleccionados del grupo que consiste en flúor, cloro, bromo y yodo y, R1, R2, R3, R4, R5 y R6 se seleccionan de manera independiente del grupo que consiste en hidrógeno y alquilo de C1-C4; en donde el alquilo de C1-C4 está sustituido opcionalmente con fenilo (en donde el fenilo está sustituido opcionalmente con sustituyentes, seleccionados de manera independiente del grupo que consiste en halógeno, alquilo de C1-C4, alcoxi de C1?C4, amino, nitro y ciano).
EC2008008172A 2005-07-12 2008-02-12 Metodos para tratar la epileptogenesis ECSP088172A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69862505P 2005-07-12 2005-07-12

Publications (1)

Publication Number Publication Date
ECSP088172A true ECSP088172A (es) 2008-03-26

Family

ID=37637731

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008172A ECSP088172A (es) 2005-07-12 2008-02-12 Metodos para tratar la epileptogenesis

Country Status (16)

Country Link
US (1) US20070021501A1 (es)
EP (1) EP1906946A2 (es)
JP (1) JP2009501223A (es)
KR (1) KR20080028485A (es)
CN (1) CN101309680A (es)
AR (1) AR054550A1 (es)
AU (1) AU2006269462A1 (es)
BR (1) BRPI0613010A2 (es)
CA (1) CA2615127A1 (es)
EA (1) EA200800295A1 (es)
EC (1) ECSP088172A (es)
IL (1) IL188728A0 (es)
NO (1) NO20080739L (es)
TW (1) TW200744575A (es)
WO (1) WO2007008551A2 (es)
ZA (1) ZA200801402B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6005357B2 (ja) * 2008-05-16 2016-10-12 ノノ インコーポレイテッド てんかんの治療
US8609849B1 (en) 2010-11-30 2013-12-17 Fox Chase Chemical Diversity Center, Inc. Hydroxylated sulfamides exhibiting neuroprotective action and their method of use
ES2998534T3 (en) 2013-03-12 2025-02-20 Bio Pharm Solutions Co Ltd Phenyl carbamate compounds for use in preventing or treating pediatric epilesy
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
EP3340971B1 (en) * 2015-08-24 2024-03-13 Zogenix International Limited Methods of treating lennox-gastaut syndrome using fenfluramine
JP6807941B2 (ja) * 2016-02-29 2021-01-06 バイオ−ファーム ソリューションズ カンパニー リミテッド スルファメート誘導体化合物、その製造方法および用途
US20190022166A1 (en) * 2017-07-18 2019-01-24 Creative Bio-Peptides Inc. Oral anti-inflammatory peptides to treat epilepsy, seizures and cns disorders
USRE50630E1 (en) 2017-10-31 2025-10-14 Creative BioPeptides, Inc. Use of an all-D-pentapeptide chemokine antagonist to reduce opioid dose in a person with pain
CN109920550A (zh) * 2018-12-25 2019-06-21 天津大学 一种基于dMRI研究青少年肌阵挛性癫痫的方法
US11510961B2 (en) 2019-12-19 2022-11-29 Creative Bio-Peptides, Inc. Methods and compositions for use of a chemokine receptor antagonist peptide to treat addiction, substance abuse disorders or symptoms thereof
CN115501344A (zh) * 2022-09-29 2022-12-23 重庆医科大学 一种铁螯合剂的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3313692A (en) * 1958-04-21 1967-04-11 Armour Pharma Method of inducing calming and muscle relaxation with carbamates
US3265728A (en) * 1962-07-18 1966-08-09 Armour Pharma Substituted phenethyl carbamates
US5698588A (en) * 1996-01-16 1997-12-16 Yukong Limited Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
US6104956A (en) * 1996-05-31 2000-08-15 Board Of Trustees Of Southern Illinois University Methods of treating traumatic brain injury by vagus nerve stimulation
DK1156798T3 (da) * 1999-02-09 2003-11-03 Univ Virginia Felbamat-afledte forbindelser
EP1368021B1 (en) * 2001-02-27 2007-11-14 Ortho-Mcneil Pharmaceutical, Inc. Carbamate compounds for use in preventing or treating bipolar disorder
CA2439475C (en) * 2001-02-27 2010-05-18 Carlos R. Plata-Salaman Carbamate compounds for use in preventing or treating bipolar disorder

Also Published As

Publication number Publication date
AU2006269462A1 (en) 2007-01-18
JP2009501223A (ja) 2009-01-15
CA2615127A1 (en) 2007-01-18
AR054550A1 (es) 2007-06-27
EA200800295A1 (ru) 2008-12-30
ZA200801402B (en) 2009-10-28
WO2007008551A3 (en) 2008-06-19
CN101309680A (zh) 2008-11-19
WO2007008551A2 (en) 2007-01-18
US20070021501A1 (en) 2007-01-25
NO20080739L (no) 2008-04-10
EP1906946A2 (en) 2008-04-09
IL188728A0 (en) 2008-11-03
KR20080028485A (ko) 2008-03-31
TW200744575A (en) 2007-12-16
BRPI0613010A2 (pt) 2010-12-14

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