ECSP088231A - MALARIA VACCINES BASED ON ADENOVIRAL VECTORS - Google Patents

MALARIA VACCINES BASED ON ADENOVIRAL VECTORS

Info

Publication number
ECSP088231A
ECSP088231A EC2008008231A ECSP088231A ECSP088231A EC SP088231 A ECSP088231 A EC SP088231A EC 2008008231 A EC2008008231 A EC 2008008231A EC SP088231 A ECSP088231 A EC SP088231A EC SP088231 A ECSP088231 A EC SP088231A
Authority
EC
Ecuador
Prior art keywords
adenoviral vectors
vaccines based
malaria vaccines
mammal
nucleic acid
Prior art date
Application number
EC2008008231A
Other languages
Spanish (es)
Inventor
Joseph T Bruder
Imre Kovesdi
C Richter King
Duncan L Mcvey
Damodar R Ettyreddy
Denise Louise Doolan
Daniel John Carucci
Keith Limbach
Original Assignee
Genvec Inc
Us Navy Naval Res Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genvec Inc, Us Navy Naval Res Lab filed Critical Genvec Inc
Publication of ECSP088231A publication Critical patent/ECSP088231A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a vectores adenovirales que comprenden un genoma adenoviral que comprende secuencias de ácido nucleico que codifican al antígeno, tales como secuencias de ácido nucleico de Plasmodium, operablemente ligadas con promotores. La invención además proporciona un método para inducir una respuesta inmune contra la malaria en un mamífero que comprende, administrar los vectores adenovirales al mamífero.The present invention relates to adenoviral vectors comprising an adenoviral genome comprising nucleic acid sequences encoding the antigen, such as Plasmodium nucleic acid sequences, operably linked with promoters. The invention further provides a method for inducing an immune response against malaria in a mammal that comprises administering adenoviral vectors to the mammal.

EC2008008231A 2005-08-31 2008-02-28 MALARIA VACCINES BASED ON ADENOVIRAL VECTORS ECSP088231A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71311005P 2005-08-31 2005-08-31

Publications (1)

Publication Number Publication Date
ECSP088231A true ECSP088231A (en) 2008-07-30

Family

ID=37697585

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008231A ECSP088231A (en) 2005-08-31 2008-02-28 MALARIA VACCINES BASED ON ADENOVIRAL VECTORS

Country Status (9)

Country Link
US (1) US8765146B2 (en)
EP (1) EP1929021A2 (en)
JP (1) JP2009505680A (en)
AU (1) AU2006284756B2 (en)
BR (1) BRPI0615400A2 (en)
CA (1) CA2620495A1 (en)
EC (1) ECSP088231A (en)
WO (1) WO2007027860A2 (en)
ZA (1) ZA200802218B (en)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9333249B2 (en) 2006-02-09 2016-05-10 Educational Foundation Jichi Medical University Recombinant baculovirus vaccine
TWI477602B (en) 2006-02-09 2015-03-21 Educational Foundation Jichi Medical Univ Novel viral vector
US20080248060A1 (en) * 2007-01-09 2008-10-09 Genvec, Inc. Adenoviral vector-based malaria vaccines
GB0706914D0 (en) * 2007-04-10 2007-05-16 Isis Innovation Novel adenovirus vectors
WO2011022002A1 (en) * 2009-08-18 2011-02-24 The Rockefeller University Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes
US9555089B2 (en) * 2009-08-18 2017-01-31 The Rockefeller University Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes
US20120219583A1 (en) 2009-10-16 2012-08-30 Los Alamos National Security, Llc Nucleic acid sequences encoding expandable hiv mosaic proteins
EP2451477A4 (en) * 2009-11-13 2013-08-14 Us Navy T-LYMPHOCYTE EPITOPES RESTRICTED BY PLASMODIUM FALCIPARUM CLASS I HLA
AU2011230619C1 (en) 2010-03-25 2016-06-23 Oregon Health & Science University CMV glycoproteins and recombinant vectors
EP2385107B1 (en) 2010-05-03 2016-08-24 Institut Pasteur Lentiviral vector based immunological compounds against malaria
TR201802741T4 (en) 2010-05-14 2018-03-21 Univ Oregon Health & Science Recombinant hcmv and rhcmv vectors and their uses.
WO2012023995A1 (en) * 2010-08-18 2012-02-23 Takayuki Shiratsuchi Modification of recombinant adenovirus capsid protein with immunogenic plasmodium circumsporozoite protein epitopes
MX355501B (en) * 2010-09-27 2018-04-20 Inovio Pharmaceuticals Inc Star Consensus antigen constructs and vaccines made therefrom, and methods of using same to treat malaria.
AU2011313913A1 (en) * 2010-10-10 2013-05-02 Aduro Biotech Methods and compositions for inducing a T-cell response to Plasmodium species
WO2012083297A2 (en) * 2010-12-17 2012-06-21 Genvec, Inc. Adenoviral vectors with modified hexon regions
WO2012088041A1 (en) * 2010-12-20 2012-06-28 Genvec, Inc. Adenoviral vector-based dengue fever vaccine
US20120219590A1 (en) * 2011-02-24 2012-08-30 Paxvax, Inc. Formulations useful for spray drying vaccines
HUE037408T2 (en) 2011-06-10 2018-08-28 Univ Oregon Health & Science CMV glycoproteins and recombinant vectors
CN103987726B (en) 2011-10-05 2017-10-03 金维克有限公司 Monkey (gorilla) adenovirus or adenoviral vector and methods of use thereof
JP6757120B2 (en) 2011-10-05 2020-09-16 ジェンヴェック エルエルシー Afen adenovirus (gorilla) or adenovirus vector, and how to use
US9233153B2 (en) 2011-10-05 2016-01-12 Genvec, Inc. Affenadenovirus (gorilla) or adenoviral vectors and methods of use
CN102559613B (en) * 2012-01-10 2014-04-23 特菲(天津)生物医药科技有限公司 Malignant malaria vaccine and preparation method thereof
WO2013116591A1 (en) * 2012-02-02 2013-08-08 Genvec, Inc. Adenoviral vector-based malaria vaccine
HK1210475A1 (en) 2012-05-29 2016-04-22 Genvec, Inc. Herpes simplex virus vaccine
WO2014075047A2 (en) * 2012-11-12 2014-05-15 Genvec, Inc. Malaria antigens and methods of use
DK2964769T3 (en) 2013-03-05 2018-12-10 Univ Oregon Health & Science Cytomegalovirus vectors enabling control of T cell targeting
SG11201507393TA (en) 2013-03-14 2015-10-29 Salk Inst For Biological Studi Oncolytic adenovirus compositions
KR20150128900A (en) * 2013-03-15 2015-11-18 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Vaccines having an antigen and interleukin-23 as an adjuvant
EP2796147A1 (en) * 2013-04-24 2014-10-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Novel vaccines against apicomplexan pathoges
CA2914790C (en) 2013-06-14 2024-02-27 Psioxus Therapeutics Limited A dosing regime and formulations for type b adenoviruses
GB201318084D0 (en) * 2013-10-11 2013-11-27 Isis Innovation Malaria vaccination
GB201322851D0 (en) 2013-12-23 2014-02-12 Psioxus Therapeutics Ltd Method
HUE035875T2 (en) 2013-10-25 2018-06-28 Psioxus Therapeutics Ltd Oncolytic adenoviruses containing heterologous genes
EP2923709A1 (en) 2014-03-28 2015-09-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Multi-component-multistage malaria vaccine
CN113528466B (en) 2014-07-16 2024-12-24 俄勒冈健康与科学大学 Human cytomegalovirus containing foreign antigens
EP2992895A1 (en) 2014-09-08 2016-03-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Three-component-multistage malaria vaccine
KR102608590B1 (en) 2014-09-24 2023-12-01 솔크 인스티튜트 포 바이올로지칼 스터디즈 Oncolytic tumor viruses and methods of use
JP6816031B2 (en) 2015-02-10 2021-01-20 オレゴン ヘルス アンド サイエンス ユニバーシティ Methods and compositions useful for generating non-standard CD8 + T cell responses
EP3081575A1 (en) 2015-04-12 2016-10-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anti-plasmodium parasite antibodies
HRP20200439T1 (en) 2015-04-30 2020-06-12 Psioxus Therapeutics Limited ONCOLYTIC ADENOVIRUS ENCODING PROTEIN B7
CN108474003A (en) 2015-11-20 2018-08-31 俄勒冈健康与科学大学 CMV vectors containing microRNA recognition elements
BR112018012180A2 (en) 2015-12-17 2018-12-04 Psioxus Therapeutics Ltd virus encoding an anti-tcr antibody or fragment
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
WO2017147269A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
JP7466271B2 (en) 2016-03-31 2024-04-12 ザ ヨーロピアン モレキュラー バイオロジー ラボラトリー Adenovirus Coat Protein-Derived Delivery Vehicles
MX2018014253A (en) 2016-05-19 2019-11-11 Univ Pennsylvania Synthetic malaria immunogens, combinations thereof, and their use to prevent and treat malaria infections.
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
IL303187A (en) 2016-08-29 2023-07-01 Akamis Bio Ltd Adenovirus armed with bispecific t cell activator
US10532099B2 (en) 2016-10-18 2020-01-14 Oregon Health & Science University Cytomegalovirus vectors eliciting T cells restricted by major histocompatibility complex E molecules
EP3532082A4 (en) 2016-12-12 2020-08-26 Salk Institute for Biological Studies SYNTHETIC ADENOVIRUS DIRECTIVE TO TUMORS AND USES THEREOF
EP3600399A4 (en) * 2017-03-30 2021-03-24 The United States of America, as represented by the Secretary of the Navy METHODS AND COMPOSITIONS FOR VACCINE AGAINST MALARIA
CN112292449A (en) 2018-04-09 2021-01-29 萨克生物研究学院 Oncolytic adenovirus compositions with enhanced replication properties
KR102169664B1 (en) * 2019-02-26 2020-10-23 원광대학교산학협력단 Vaccine composition for preventing malaria comprising recombinant EF-1α protein derived from Plasmodium falciparum as effective component
WO2025024324A1 (en) * 2023-07-21 2025-01-30 BioNTech SE Compositions for delivery of plasmodium antigens and related methods

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5766597A (en) * 1991-03-07 1998-06-16 Virogenetics Corporation Malaria recombinant poxviruses
GB9223084D0 (en) 1992-11-04 1992-12-16 Imp Cancer Res Tech Compounds to target cells
FR2705686B1 (en) 1993-05-28 1995-08-18 Transgene Sa New defective adenoviruses and corresponding complementation lines.
SK282843B6 (en) 1993-07-13 2002-12-03 Rhone-Poulenc Rorer S. A. Defective recombinant adenovirus and pharmaceutical composition thereof
US5543328A (en) 1993-08-13 1996-08-06 Genetic Therapy, Inc. Adenoviruses having modified fiber proteins
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
WO1995016772A1 (en) 1993-12-14 1995-06-22 Cornell Research Foundation, Inc. Adenovirus gene expression system
ATE336587T1 (en) 1994-06-10 2006-09-15 Genvec Inc ADENOVIRUS VECTOR SYSTEMS AND CELL LINES
US5851806A (en) 1994-06-10 1998-12-22 Genvec, Inc. Complementary adenoviral systems and cell lines
US5962311A (en) 1994-09-08 1999-10-05 Genvec, Inc. Short-shafted adenoviral fiber and its use
US6465253B1 (en) 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US5559099A (en) 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US5965541A (en) 1995-11-28 1999-10-12 Genvec, Inc. Vectors and methods for gene transfer to cells
IL116816A (en) 1995-01-20 2003-05-29 Rhone Poulenc Rorer Sa Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof
US6127525A (en) 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
US5770442A (en) 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
IL160406A0 (en) 1995-06-15 2004-07-25 Crucell Holland Bv A cell harbouring nucleic acid encoding adenoritus e1a and e1b gene products
US5801030A (en) 1995-09-01 1998-09-01 Genvec, Inc. Methods and vectors for site-specific recombination
US5837511A (en) 1995-10-02 1998-11-17 Cornell Research Foundation, Inc. Non-group C adenoviral vectors
EE9800160A (en) 1995-11-28 1998-12-15 Genvec, Inc. Vectors and methods for gene transfer into cells
JP2001520511A (en) 1995-12-08 2001-10-30 ザ ユーナヴァーサティ オブ アラバマ アト バーミングハム リサーチ ファンデーション Targeting adenovirus vector
US5922315A (en) * 1997-01-24 1999-07-13 Genetic Therapy, Inc. Adenoviruses having altered hexon proteins
US5849561A (en) 1997-05-22 1998-12-15 Cornell Research Foundation, Inc. Method for the production of non-group C adenoviral vectors
CA2291323A1 (en) 1997-05-28 1998-12-03 Genvec, Inc. Alternatively targeted adenovirus
JP2001517455A (en) 1997-09-23 2001-10-09 ジェンベク、インコーポレイティッド Plasmids for construction of eukaryotic virus vectors
US6113913A (en) 1998-06-26 2000-09-05 Genvec, Inc. Recombinant adenovirus
US6455314B1 (en) 1998-09-11 2002-09-24 Genvec, Inc. Alternatively targeted adenovirus
US6225113B1 (en) 1998-12-04 2001-05-01 Genvec, Inc. Use of trans-activation and cis-activation to modulate the persistence of expression of a transgene in an at least E4-deficient adenovirus
US6225289B1 (en) 1998-12-10 2001-05-01 Genvec, Inc. Methods and compositions for preserving adenoviral vectors
CN100352921C (en) * 1999-05-06 2007-12-05 威克福雷大学 Compositions and methods for identifying antigens that elicit an immune response
AU2001234981A1 (en) 2000-02-09 2001-08-20 Genvec, Inc. Adenoviral capsid containing chimeric protein ix
WO2001092549A2 (en) 2000-05-31 2001-12-06 Genvec, Inc. Method and composition for targeting an adenoviral vector
US20020155127A1 (en) * 2000-06-02 2002-10-24 Danher Wang Genetic vaccine against human immunodeficiency virus
US6677156B2 (en) 2001-07-23 2004-01-13 Genvec, Inc. Non-adenoviral gene product-based complementing cells for adenoviral vectors
AU2002327380A1 (en) 2001-07-23 2003-03-18 Genvec, Inc. Cells and methods for propagating adenoviral vectors
US6682929B2 (en) 2001-07-23 2004-01-27 Genvec, Inc. Adenovector complementing cells
JP2005503797A (en) 2001-09-13 2005-02-10 ジェンベク、インコーポレイティッド Adenoviral vectors and related systems, and methods of manufacture and use
US20030133912A1 (en) * 2001-12-11 2003-07-17 Davidson Beverly L. Receptor-targeted adenoviral vectors
US20030153065A1 (en) 2002-01-14 2003-08-14 Genvec, Inc. Composition and method for maintaining non-enveloped viral vectors
SI1504108T1 (en) * 2002-02-01 2013-07-31 Oxford Biomedica (Uk) Limited Lentiviral vector

Also Published As

Publication number Publication date
WO2007027860A2 (en) 2007-03-08
AU2006284756A8 (en) 2010-04-29
US20090148477A1 (en) 2009-06-11
AU2006284756B2 (en) 2012-06-07
CA2620495A1 (en) 2007-03-08
AU2006284756A2 (en) 2008-04-24
JP2009505680A (en) 2009-02-12
ZA200802218B (en) 2009-04-29
AU2006284756A1 (en) 2007-03-08
WO2007027860A3 (en) 2007-12-27
BRPI0615400A2 (en) 2011-05-17
US8765146B2 (en) 2014-07-01
EP1929021A2 (en) 2008-06-11

Similar Documents

Publication Publication Date Title
ECSP088231A (en) MALARIA VACCINES BASED ON ADENOVIRAL VECTORS
NO20072470L (en) Malaria Initiator / amplifier vaccine
CY1121528T1 (en) RECOMMENDATED GALLID 3 HARPETIC CARRIERS (MDV SEROTYP 2) EXPRESSING ANTIGENS OF BIRD PATHOGENS AND THEIR USES
WO2012106377A3 (en) Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof
BR112015010318A2 (en) ALBUMIN VARIANTS
MX2008016036A (en) Recombinant viral vaccine.
EA201591888A1 (en) REPLICATION-DEFECT VACCINES AND VACCINE VECTORS AGAINST FLAVIVIRUSS
PH12015500308B1 (en) Hepatitis b virus core protein and surface antigen protein and vaccine comprising the same
MX2012008651A (en) Influenza nucleic acid molecules and vaccines made therefrom.
PH12014502438A1 (en) Prostate-associated antigens and vaccine-based immunotherapy regimens
CO6150189A2 (en) VACCINES FOR MALARIA
EP3330283A3 (en) Albumin variants
WO2015052543A3 (en) Malaria vaccination
MX343830B (en) Nucleic acid molecule encoding hepatitis b virus core protein and vaccine comprising the same.
CY1120430T1 (en) RECOMMENDED CDV COMPOSITIONS AND USES OF THESE
MX2012013405A (en) Reflective decoration assembly.
MY188100A (en) Compositions and methods vectors for inducing an enhanced immune response using poxvirus vectors
WO2011057254A3 (en) Simian adenoviral vector-based vaccines
WO2008086386A3 (en) Adenoviral vector-based malaria vaccines
CO6670515A2 (en) Parapoxvirus Vectors
MX354752B (en) Heterologous prime boost vaccination regimen against malaria.
MX2010007876A (en) Recombinant viral vectors and vaccine composition for leishmaniasis.
ES2524894T3 (en) Permanent human amniocyte cell line for influenza virus production
WO2008118936A3 (en) Method of elicting immune response with a modified mva viral hiv-1 vector
BR112012004703A2 (en) heterologous booster initial immunization regimen against bluetongue virus.