ECSP088293A - Inhibidores de gamma secretasa, de sulfonamido n-cíclico puenteado - Google Patents

Inhibidores de gamma secretasa, de sulfonamido n-cíclico puenteado

Info

Publication number
ECSP088293A
ECSP088293A EC2008008293A ECSP088293A ECSP088293A EC SP088293 A ECSP088293 A EC SP088293A EC 2008008293 A EC2008008293 A EC 2008008293A EC SP088293 A ECSP088293 A EC SP088293A EC SP088293 A ECSP088293 A EC SP088293A
Authority
EC
Ecuador
Prior art keywords
formula
compounds
secretasa
sulfonamide
gamma
Prior art date
Application number
EC2008008293A
Other languages
English (en)
Inventor
Andrei Konradi
Christopher M Semko
Matthew N Mattson
Xiacong Michael Ye
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of ECSP088293A publication Critical patent/ECSP088293A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La invención provee compuestos de sulfonamido N-cíclicos y sales de la Fórmula: , donde A se define conforme a lo descripto en la memoria descriptiva, y R1 y R2 se combinan para formar un sistema de anillo [3.3.1] o [3.2.1], donde el nitrógeno está unido a los dos carbonos puenteados, y los sistemas de anillo [3.3.1] o [3.2.1] están opcionalmente fusionados con un anillo heteroarilo o heterocicloalquilo. Los compuestos de Fórmula I son útiles en el tratamiento o la prevención de trastornos cognitivos, tales como la enfermedad de Alzheimer. La invención además contempla composiciones farmacéuticas que comprenden compuestos de Fórmula I; métodos de tratamiento de trastornos cognitivos, tales como la enfermedad de Alzheimer; y los intermediarios útiles para la preparación de los compuestos de Fórmula I.
EC2008008293A 2005-08-19 2008-03-18 Inhibidores de gamma secretasa, de sulfonamido n-cíclico puenteado ECSP088293A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70996105P 2005-08-19 2005-08-19

Publications (1)

Publication Number Publication Date
ECSP088293A true ECSP088293A (es) 2008-04-28

Family

ID=37758487

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008293A ECSP088293A (es) 2005-08-19 2008-03-18 Inhibidores de gamma secretasa, de sulfonamido n-cíclico puenteado

Country Status (16)

Country Link
US (4) US7345056B2 (es)
EP (2) EP1915371A4 (es)
JP (2) JP2009504773A (es)
KR (1) KR20080042135A (es)
CN (2) CN101426860A (es)
AR (1) AR056470A1 (es)
AU (2) AU2006279312A1 (es)
BR (1) BRPI0614944A2 (es)
CA (2) CA2632670A1 (es)
EC (1) ECSP088293A (es)
IL (2) IL189217A0 (es)
MX (1) MX2008002234A (es)
RU (2) RU2008110488A (es)
TW (1) TW200740806A (es)
WO (2) WO2007024651A2 (es)
ZA (1) ZA200803521B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7923465B2 (en) 2005-06-02 2011-04-12 Glenmark Pharmaceuticals S.A. Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
AU2006279312A1 (en) * 2005-08-19 2007-02-22 Elan Pharmaceuticals, Inc. Bridged N-cyclic sulfonamido inhibitors of gamma secretase
AR057959A1 (es) * 2005-12-01 2007-12-26 Elan Pharm Inc 5-pirazolpiperidinas-(sustituidas)
AU2008256940A1 (en) 2007-05-25 2008-12-04 Elan Pharmaceuticals, Inc. Pyrazolopyrrolidines as inhibitors of gamma secretase
JP2010536749A (ja) * 2007-08-15 2010-12-02 シェーリング コーポレイション １１β−ヒドロキシステロイドデヒドロゲナーゼＩ型を阻害するのに有用な置換二環式ピペリジニルスルホンアミドおよびピペラジニルスルホンアミド
RU2544856C2 (ru) 2008-01-25 2015-03-20 Сергей Олегович Бачурин НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
CL2009000725A1 (es) 2008-03-24 2009-05-29 Medivation Technologies Inc Compuestos derivados de heterociclos con uniones puente sustituidos, moduladores de receptores adrenergicos, de serotonina, de dopamina y de histaminas; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento del trastorno cognitivo y trastorno psicotico.
JP2012502051A (ja) * 2008-09-05 2012-01-26 エラン ファーマシューティカルズ，インコーポレイテッド Ｎ−スルホンアミドポリシクル酸ピラゾリル化合物
WO2011038164A1 (en) 2009-09-23 2011-03-31 Medivation Technologies, Inc. Bridged heterocyclic compounds and methods of use
CA2775328A1 (en) 2009-09-23 2011-03-31 Medivation Technologies, Inc. Pyrido[4,3-b]indoles and methods of use
AR079493A1 (es) 2009-12-21 2012-02-01 Nippon Soda Co Compuesto de amina ciclica y acaricida
AR081721A1 (es) 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
JP2013536233A (ja) 2010-08-23 2013-09-19 アムジエン・インコーポレーテツド グルコキナーゼ調節タンパク質と相互作用する糖尿病治療用の化合物
US8791132B2 (en) 2011-02-18 2014-07-29 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
WO2013019901A2 (en) * 2011-08-02 2013-02-07 Buck Institute For Research On Aging Tropinol esters and related compounds to promote normal processing of app
EP2690102A1 (en) 2012-07-24 2014-01-29 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Bicyclic aza-amides for treatment of psychiatric disorders
WO2016187772A1 (zh) * 2015-05-25 2016-12-01 华为技术有限公司 一种光致变色镜头、摄像头及终端设备

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
JPH01132585A (ja) * 1987-11-17 1989-05-25 Kyowa Hakko Kogyo Co Ltd Ｄｃ−５２誘導体
US5256656A (en) * 1990-07-31 1993-10-26 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives
JP3218621B2 (ja) * 1990-10-11 2001-10-15 住友化学工業株式会社 芳香族系化合物、その製造法およびそれを有効成分とする有害生物防除剤
GB9510459D0 (en) * 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
KR100266467B1 (ko) * 1995-09-27 2000-10-02 우에노 도시오 설폰아미드 유도체
NZ321970A (en) * 1995-11-02 2000-02-28 Neurosearch As Fused tropane-derivatives as neurotransmitter reuptake inhibitors
EP1006113A1 (en) * 1998-12-02 2000-06-07 Pfizer Products Inc. Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
PL350884A1 (en) 1999-04-01 2003-02-10 Pfizer Prod Inc Aminopyrimidines as sorbitol dehydrogenase inhibitors
ES2240017T3 (es) * 1999-09-30 2005-10-16 Pfizer Products Inc. Derivados de 6-azauracilo como ligandos de receptores tiroideos.
EP1118612A1 (en) * 2000-01-21 2001-07-25 Universita Degli Studi di Firenze Piperazine derivatives possesing nootropic activity
CA2446795A1 (en) * 2001-05-10 2002-11-14 Agouron Pharmaceuticals, Inc. Sulfamide, sulfamate, sulfonamide, urea, amide, alpha, alpha-difluoro amide oxalyl diamide, and heterobicycles fkbp-binding ligands
GB0119152D0 (en) 2001-08-06 2001-09-26 Merck Sharp & Dohme Therapeutic agents
TW200302717A (en) * 2002-02-06 2003-08-16 Schering Corp Novel gamma secretase inhibitors
HUP0202001A2 (hu) * 2002-06-14 2005-08-29 Sanofi-Aventis DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
WO2004101562A2 (en) * 2003-05-13 2004-11-25 Schering Corporation Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors
MX2007000015A (es) * 2004-06-22 2007-03-07 Schering Corp Ligandos de receptor de canabinoide.
CA2585172C (en) * 2004-10-29 2014-08-12 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as modulators of ppar
US7615570B2 (en) * 2004-12-13 2009-11-10 Abbott Laboratories Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
AU2006279312A1 (en) * 2005-08-19 2007-02-22 Elan Pharmaceuticals, Inc. Bridged N-cyclic sulfonamido inhibitors of gamma secretase

Also Published As

Publication number Publication date
RU2422443C2 (ru) 2011-06-27
CN101304997A (zh) 2008-11-12
WO2007022502A2 (en) 2007-02-22
US7754712B2 (en) 2010-07-13
RU2008133306A (ru) 2010-02-20
CN101426860A (zh) 2009-05-06
IL190970A0 (en) 2009-02-11
WO2007024651A3 (en) 2007-07-12
BRPI0614944A2 (pt) 2011-04-26
MX2008002234A (es) 2008-03-27
JP2009504773A (ja) 2009-02-05
US20070049612A1 (en) 2007-03-01
WO2007022502A3 (en) 2007-10-04
EP1916985A4 (en) 2010-06-09
EP1915371A2 (en) 2008-04-30
WO2007024651A2 (en) 2007-03-01
ZA200803521B (en) 2009-12-30
US20110003802A1 (en) 2011-01-06
KR20080042135A (ko) 2008-05-14
CA2632670A1 (en) 2007-02-22
US7345056B2 (en) 2008-03-18
AR056470A1 (es) 2007-10-10
AU2006279312A1 (en) 2007-02-22
IL189217A0 (en) 2008-06-05
JP2009506988A (ja) 2009-02-19
EP1916985A2 (en) 2008-05-07
AU2006283567A1 (en) 2007-03-01
US20110178119A1 (en) 2011-07-21
TW200740806A (en) 2007-11-01
EP1915371A4 (en) 2010-09-15
RU2008110488A (ru) 2009-09-27
US20080090817A1 (en) 2008-04-17
CA2618087A1 (en) 2007-03-01

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