ECSP088352A - Derivados de indol 1,3-disustituido para su uso como moduladores de ppar - Google Patents

Derivados de indol 1,3-disustituido para su uso como moduladores de ppar

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Publication number
ECSP088352A
ECSP088352A EC2008008352A ECSP088352A ECSP088352A EC SP088352 A ECSP088352 A EC SP088352A EC 2008008352 A EC2008008352 A EC 2008008352A EC SP088352 A ECSP088352 A EC SP088352A EC SP088352 A ECSP088352 A EC SP088352A
Authority
EC
Ecuador
Prior art keywords
disposed
ppar modulators
indol derivatives
indol
derivatives
Prior art date
Application number
EC2008008352A
Other languages
English (en)
Inventor
Prabha N Ibrahim
Jack Lin
Weiru Wang
Chao Zhang
Shenghua Shi
Dean R Artis
Patrick Womack
Byunghun Lee
Rebecca Zuckerman
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of ECSP088352A publication Critical patent/ECSP088352A/es

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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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Abstract

1. Un compuesto que tiene la estructura químicatodas las sales, profármacos, tautómeros e isómeros de los mismos
EC2008008352A 2005-09-07 2008-04-07 Derivados de indol 1,3-disustituido para su uso como moduladores de ppar ECSP088352A (es)

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AU2006287513A1 (en) 2007-03-15
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IL189776A0 (en) 2008-08-07
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ZA200802007B (en) 2008-12-31
JP2009507079A (ja) 2009-02-19
EP1943245A2 (en) 2008-07-16
CN101304992A (zh) 2008-11-12
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WO2007030559A2 (en) 2007-03-15
CR9868A (es) 2008-05-08
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