ECSP088599A - Virus quiméricos que presentan proteínas de superficie no nativas y usos de los mismos - Google Patents

Virus quiméricos que presentan proteínas de superficie no nativas y usos de los mismos

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Publication number
ECSP088599A
ECSP088599A EC2008008599A ECSP088599A ECSP088599A EC SP088599 A ECSP088599 A EC SP088599A EC 2008008599 A EC2008008599 A EC 2008008599A EC SP088599 A ECSP088599 A EC SP088599A EC SP088599 A ECSP088599 A EC SP088599A
Authority
EC
Ecuador
Prior art keywords
chimeric
protein
viruses
infectious agent
ndv
Prior art date
Application number
EC2008008599A
Other languages
English (en)
Inventor
Peter Palese
Sastre Adolfo Garcia
Original Assignee
Sinai School Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38092581&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP088599(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sinai School Medicine filed Critical Sinai School Medicine
Publication of ECSP088599A publication Critical patent/ECSP088599A/es

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    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
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    • A61P31/12—Antivirals
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    • A61K2039/525—Virus
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C12N2760/16011—Orthomyxoviridae
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18141—Use of virus, viral particle or viral elements as a vector
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    • C12N2760/18011—Paramyxoviridae
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Abstract

La presente invención proporciona virus de RNA de cadena negativa quiméricos que permiten a un sujeto, por ejemplo, un ave, estar inmunizado contra dos agentes infecciosos mediante la utilización de un solo virus quimérico de la invención. En particular, la presente invención ofrece virus de influenza quiméricos manipulados para expresar e incorporar en sus viriones una proteína de fusión que comprende un ectodominio de una proteína de un agente infeccioso y el dominio de transmembrana y dominio citoplásmico de una proteína de virus de influenza. Tales virus quiméricos inducen la respuesta inmune contra el virus de la influenza y el agente infeccioso. La presente invención ofrece también virus de enfermedad de New Castle (NDV) quiméricos manipulados para expresar e incorporar en sus viriones una proteína de fusión que comprende el ectodominio de una proteína de un agente infeccioso y el dominio de transmembrana y dominio citoplásmico de una proteína de NDV. Tales virus quiméricos inducen una respuesta inmune contra NDV y el agente infeccioso.
EC2008008599A 2005-12-02 2008-07-02 Virus quiméricos que presentan proteínas de superficie no nativas y usos de los mismos ECSP088599A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74183305P 2005-12-02 2005-12-02
US80286406P 2006-05-22 2006-05-22

Publications (1)

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ECSP088599A true ECSP088599A (es) 2008-08-29

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EC2008008599A ECSP088599A (es) 2005-12-02 2008-07-02 Virus quiméricos que presentan proteínas de superficie no nativas y usos de los mismos

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US (2) US9387242B2 (es)
EP (3) EP2251034B1 (es)
JP (1) JP5603012B2 (es)
KR (1) KR101492643B1 (es)
CN (1) CN101365479B (es)
AP (1) AP2911A (es)
AU (1) AU2006320490A1 (es)
CA (1) CA2631812C (es)
CL (1) CL2006003348A1 (es)
CR (1) CR10064A (es)
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