ECSP088700A - Acidos 4-fenil-tiazol-5-carboxilicos y amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1 - Google Patents

Acidos 4-fenil-tiazol-5-carboxilicos y amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1

Info

Publication number
ECSP088700A
ECSP088700A EC2008008700A ECSP088700A ECSP088700A EC SP088700 A ECSP088700 A EC SP088700A EC 2008008700 A EC2008008700 A EC 2008008700A EC SP088700 A ECSP088700 A EC SP088700A EC SP088700 A ECSP088700 A EC SP088700A
Authority
EC
Ecuador
Prior art keywords
tiazol
phenyl
carboxilic acids
plk1
inhibitors
Prior art date
Application number
EC2008008700A
Other languages
English (en)
Inventor
Christophe Michoud
Nader Fotouhi
Paul Gillespie
Robert Alan Goodnow
Kang Le
John Frederick Boylan
Jianping Cai
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ECSP088700A publication Critical patent/ECSP088700A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

La invención se refiere a compuestos de la fórmula (1) (1)y a sales farmacéuticamente aceptables de los mismos, a métodos para su obtención y a métodos para la utilización de los mismos.
EC2008008700A 2006-02-27 2008-08-26 Acidos 4-fenil-tiazol-5-carboxilicos y amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1 ECSP088700A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77696406P 2006-02-27 2006-02-27

Publications (1)

Publication Number Publication Date
ECSP088700A true ECSP088700A (es) 2008-09-29

Family

ID=38051896

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008700A ECSP088700A (es) 2006-02-27 2008-08-26 Acidos 4-fenil-tiazol-5-carboxilicos y amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1

Country Status (19)

Country Link
US (1) US7504513B2 (es)
EP (1) EP1991543A1 (es)
JP (1) JP2009528284A (es)
KR (1) KR101060539B1 (es)
CN (1) CN101415704A (es)
AR (1) AR059621A1 (es)
AU (1) AU2007217575A1 (es)
BR (1) BRPI0710473A2 (es)
CA (1) CA2642921A1 (es)
CR (1) CR10206A (es)
EC (1) ECSP088700A (es)
IL (1) IL193481A0 (es)
MA (1) MA30260B1 (es)
MX (1) MX2008010884A (es)
NO (1) NO20083708L (es)
RU (1) RU2008138163A (es)
TW (1) TW200745097A (es)
WO (1) WO2007096315A1 (es)
ZA (1) ZA200807074B (es)

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WO2008149784A1 (ja) * 2007-06-08 2008-12-11 Nec Corporation 半導体集積回路及びフィルタ制御方法
US9029411B2 (en) 2008-01-25 2015-05-12 Millennium Pharmaceuticals, Inc. Thiophenes and uses thereof
US8962614B2 (en) * 2008-04-17 2015-02-24 The Johns Hopkins University ON01910.Na enhances chemotherapeutic agent activity in drug-resistant tumors
WO2010029327A1 (en) * 2008-09-10 2010-03-18 Datalase Ltd. Data storage medium
WO2010077295A1 (en) * 2008-12-09 2010-07-08 King Faisal Specialist Hospital & Research Centre Substituted tricyclic heterocycles and uses to treat tumors and proliferative disorders
WO2010121675A2 (en) * 2008-12-18 2010-10-28 F. Hoffmann-La Roche Ag Thiazolyl-benzimidazoles
WO2010090716A1 (en) 2009-01-30 2010-08-12 Millennium Pharmaceuticals, Inc. Heteroaryls and their use as pi3k inhibitors
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US9090601B2 (en) * 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
TW201217365A (en) 2010-08-11 2012-05-01 Millennium Pharm Inc Heteroaryls and uses thereof
WO2012021611A1 (en) 2010-08-11 2012-02-16 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US8859768B2 (en) 2010-08-11 2014-10-14 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
TW201307309A (zh) 2010-10-13 2013-02-16 Millennium Pharm Inc 雜芳基化合物及其用途

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US4322429A (en) * 1980-09-16 1982-03-30 Eli Lilly And Company Isoxazolylbenzamides as insecticides
US4818270A (en) * 1986-08-28 1989-04-04 Monsanto Company 2-(Heteroamino)-4,5-substituted-oxazole/thiazole compounds as herbicide antidotes, compositions and use
US6194447B1 (en) * 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
DK1320531T3 (da) 2000-08-10 2011-01-03 Pfizer Italia Srl Bicyclo-pyrazoler, der er aktive som kinase inhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger, der indeholder disse
GB0102687D0 (en) 2001-02-02 2001-03-21 Pharmacia & Upjohn Spa Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
CA2515243A1 (en) 2002-02-22 2003-08-28 Klaus Strebhardt Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases and pharmaceutical composition containing said agent
US7183276B2 (en) * 2002-02-28 2007-02-27 Takeda Pharmaceutical Company Limited Azole compounds
WO2003072062A2 (en) 2002-02-28 2003-09-04 Temple University-Of The Commonwealth System Of Higher Education Amino-substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders
JP2003321460A (ja) * 2002-02-28 2003-11-11 Takeda Chem Ind Ltd アゾール化合物
US20060079503A1 (en) 2002-05-03 2006-04-13 Schering Aktiengesellschaft Thiazolidinones and the use therof as polo-like kinase inhibitors
US6906186B1 (en) 2002-07-30 2005-06-14 Isis Pharmaceuticals, Inc. Antisense modulation of polo-like kinase expression
BR0313160A (pt) * 2002-08-08 2005-07-12 Smithkline Beecham Corp Composto, composição farmacêutica, métodos para tratar uma condição e um neoplasmo suscetìvel em um animal em um animal, processo para preparar um composto e uso de um composto
US20050196808A1 (en) 2002-11-14 2005-09-08 Yaffe Michael B. Products and processes for modulating peptide-peptide binding domain interactions
AU2003284399A1 (en) 2002-11-14 2004-06-03 Kyowa Hakko Kogyo Co., Ltd. Plk inhibitors
JP3837670B2 (ja) 2002-12-12 2006-10-25 富士通株式会社 データ中継装置、連想メモリデバイス、および連想メモリデバイス利用情報検索方法
GB0302220D0 (en) 2003-01-30 2003-03-05 Cyclacel Ltd Use
ES2325440T3 (es) 2003-02-20 2009-09-04 Smithkline Beecham Corporation Compuestos de pirimidina.
JP2006522127A (ja) 2003-04-01 2006-09-28 スミスクライン ビーチャム コーポレーション イミダゾトリアジン化合物
EP1641780B1 (en) 2003-06-24 2008-11-12 Pfizer Products Incorporated Processes for the preparation of 1- [(benzoimidazole-1yl) quinolin-8-yl] piperidin-4-ylamine derivatives
WO2005019193A2 (en) 2003-08-20 2005-03-03 Smithkline Beecham Corporation Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk)
JP5164380B2 (ja) 2003-10-21 2013-03-21 サイクラセル リミテッド ピリミジン−４−イル−３，４−チオン化合物及び治療におけるその使用
DE10351744A1 (de) 2003-10-31 2005-06-16 Schering Ag Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel
EP1711496A4 (en) 2004-01-28 2009-02-11 Smithkline Beecham Corp THIAZOLE COMPOUNDS

Also Published As

Publication number Publication date
BRPI0710473A2 (pt) 2011-08-16
CR10206A (es) 2008-09-22
US7504513B2 (en) 2009-03-17
IL193481A0 (en) 2009-05-04
AU2007217575A1 (en) 2007-08-30
TW200745097A (en) 2007-12-16
MA30260B1 (fr) 2009-03-02
US20070203210A1 (en) 2007-08-30
ZA200807074B (en) 2009-10-28
NO20083708L (no) 2008-09-23
RU2008138163A (ru) 2010-04-10
EP1991543A1 (en) 2008-11-19
AR059621A1 (es) 2008-04-16
CN101415704A (zh) 2009-04-22
MX2008010884A (es) 2008-09-03
JP2009528284A (ja) 2009-08-06
WO2007096315A1 (en) 2007-08-30
KR20080090550A (ko) 2008-10-08
CA2642921A1 (en) 2007-08-30
KR101060539B1 (ko) 2011-08-30

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