ECSP099044A - Compuestos de pirimido fusionados - Google Patents

Compuestos de pirimido fusionados

Info

Publication number
ECSP099044A
ECSP099044A EC2009009044A ECSP099044A ECSP099044A EC SP099044 A ECSP099044 A EC SP099044A EC 2009009044 A EC2009009044 A EC 2009009044A EC SP099044 A ECSP099044 A EC SP099044A EC SP099044 A ECSP099044 A EC SP099044A
Authority
EC
Ecuador
Prior art keywords
fusioned
pyrimid
compounds
therapy
manufacture
Prior art date
Application number
EC2009009044A
Other languages
English (en)
Inventor
Christopher Thomas Halsall
David Alan Rudge
Iain Simpson
Richard Andrew Ward
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP099044A publication Critical patent/ECSP099044A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se proporciona un compuesto de fórmula (I), procesos para la fabricación del mismo, composiciones farmacéuticas del mismo y su uso en terapia
EC2009009044A 2006-07-06 2009-01-09 Compuestos de pirimido fusionados ECSP099044A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81887806P 2006-07-06 2006-07-06

Publications (1)

Publication Number Publication Date
ECSP099044A true ECSP099044A (es) 2009-02-27

Family

ID=38857945

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009044A ECSP099044A (es) 2006-07-06 2009-01-09 Compuestos de pirimido fusionados

Country Status (19)

Country Link
US (1) US7709471B2 (es)
EP (1) EP2046793A2 (es)
JP (1) JP2009542613A (es)
KR (1) KR20090038895A (es)
CN (1) CN101511836A (es)
AR (1) AR061850A1 (es)
AU (1) AU2007270931A1 (es)
BR (1) BRPI0714045A2 (es)
CA (1) CA2656936A1 (es)
CL (1) CL2007001973A1 (es)
EC (1) ECSP099044A (es)
IL (1) IL196207A0 (es)
MX (1) MX2009000220A (es)
NO (1) NO20090052L (es)
RU (1) RU2009103810A (es)
TW (1) TW200808325A (es)
UY (1) UY30472A1 (es)
WO (1) WO2008003958A2 (es)
ZA (1) ZA200900073B (es)

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US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
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CN103122001A (zh) * 2007-09-25 2013-05-29 武田药品工业株式会社 Polo样激酶抑制剂
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WO2009089459A1 (en) 2008-01-09 2009-07-16 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
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GEAP202213376A (en) 2009-06-17 2022-02-25 Vertex Pharmaceuticals Incorporated Us Inhibitors of influenza viruses replication
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KR20120096474A (ko) * 2009-09-25 2012-08-30 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제로서 유용한 피리미딘 유도체의 제조 방법
US8466155B2 (en) * 2009-10-02 2013-06-18 Boehringer Ingelheim International Gmbh Pyrimidines
US8673275B2 (en) 2010-03-02 2014-03-18 Basf Se Block copolymers and their use
US20110218295A1 (en) * 2010-03-02 2011-09-08 Basf Se Anionic associative rheology modifiers
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
CN103841975A (zh) 2011-04-01 2014-06-04 基因泰克公司 Akt抑制剂化合物和厄洛替尼的组合以及使用方法
CN103841976A (zh) 2011-04-01 2014-06-04 基因泰克公司 Akt和mek抑制剂化合物的组合及其使用方法
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
GB201205752D0 (en) * 2012-03-30 2012-05-16 Cyclacel Ltd Treatment
LT3068776T (lt) 2013-11-13 2019-08-12 Vertex Pharmaceuticals Incorporated Gripo virusų replikacijos inhibitoriai
HUE052178T2 (hu) 2013-11-13 2021-04-28 Vertex Pharma Eljárások influenzavírus-replikáció inhibitorainak elõállítására
GB201403536D0 (en) 2014-02-28 2014-04-16 Cancer Rec Tech Ltd Inhibitor compounds
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤
CN107949279A (zh) * 2015-07-06 2018-04-20 得克萨斯系统大学评议会 可用作用于治疗人类癌症的抗癌剂的苯甲酰胺或苯扎明化合物
WO2017177092A1 (en) * 2016-04-07 2017-10-12 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating pi3k-mediated disorders
JP2023515620A (ja) * 2020-02-28 2023-04-13 リミックス セラピューティクス インコーポレイテッド スプライシングを調節するための化合物及び方法
WO2022145989A1 (ko) * 2020-12-31 2022-07-07 (주) 업테라 선택적 plk1 억제제로서의 피리미도디아제핀 유도체
WO2023017442A1 (en) * 2021-08-10 2023-02-16 Uppthera, Inc. Novel plk1 degradation inducing compound
IL311135A (en) * 2021-08-30 2024-04-01 Remix Therapeutics Inc Compounds and methods for modulating splicing
CN113999244B (zh) * 2021-12-30 2022-05-20 北京鑫开元医药科技有限公司 一种4H-吡喃并[2,3-c]吡啶-4-酮类化合物及其制备方法
CN114392258B (zh) * 2021-12-30 2024-04-16 北京朗瑞邦科技有限公司 一种4H-吡喃并[2,3-c]吡啶-4-酮类化合物药物制剂及其制备方法
TW202345806A (zh) 2022-03-31 2023-12-01 美商艾伯維有限公司 噻唑并〔５，４－ｂ〕吡啶ｍａｌｔ－１抑制劑

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Also Published As

Publication number Publication date
WO2008003958A2 (en) 2008-01-10
CL2007001973A1 (es) 2008-04-04
US7709471B2 (en) 2010-05-04
EP2046793A2 (en) 2009-04-15
UY30472A1 (es) 2008-02-29
BRPI0714045A2 (pt) 2012-12-11
WO2008003958A3 (en) 2008-03-06
CA2656936A1 (en) 2008-01-10
ZA200900073B (en) 2010-06-30
TW200808325A (en) 2008-02-16
NO20090052L (no) 2009-01-28
RU2009103810A (ru) 2010-08-20
CN101511836A (zh) 2009-08-19
JP2009542613A (ja) 2009-12-03
MX2009000220A (es) 2009-01-22
IL196207A0 (en) 2009-09-22
AR061850A1 (es) 2008-09-24
US20080009482A1 (en) 2008-01-10
AU2007270931A1 (en) 2008-01-10
KR20090038895A (ko) 2009-04-21

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