ECSP099377A - AMIDAS OF SELECTIVE DIAZABICICLOALCANS OF THE SUBTIPO OF THE NICOTINIC RECEIVER OF ACETILCOLINA - Google Patents
AMIDAS OF SELECTIVE DIAZABICICLOALCANS OF THE SUBTIPO OF THE NICOTINIC RECEIVER OF ACETILCOLINAInfo
- Publication number
- ECSP099377A ECSP099377A ECSP099377A ECSP099377A EC SP099377 A ECSP099377 A EC SP099377A EC SP099377 A ECSP099377 A EC SP099377A EC SP099377 A ECSP099377 A EC SP099377A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- effects
- significant
- nicotinic receptors
- subtipo
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 6
- 230000000694 effects Effects 0.000 abstract 4
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 2
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 2
- -1 amide compounds Chemical class 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 230000002411 adverse Effects 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000002027 skeletal muscle Anatomy 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen compuestos, composiciones farmacéuticas que incluyen los compuestos, y métodos de preparación y uso de los mismos. Los compuestos son compuestos amida que se pueden preparar a partir de ciertos ácido heteoraril carboxílicos y ciertos diazabicicloalcanos. Los compuestos exhiben selectividad para, y unión con alta afinidad con, receptores nicotínicos neuronales del subtipo a4ß2 en el sistema nervioso central (SNC). Se pueden utilizar los compuestos y composiciones para tratar y/o evitar una amplia variedad de afecciones o trastornos, particularmente trastornos del SNC. Los compuestos pueden: (i) alterar el número de receptores nicotínicos colinérgicos del cerebro del paciente, (ii) exhibir efectos neuroprotectores, y (iii) cuando se emplean en cantidades efectivas, no resultan en efectos colaterales adversos apreciables (por ejemplo efectos colaterales tales como incrementos significativos en la presión sanguínea y frecuencia cardiaca, efectos negativos significativos sobre el tracto gastrointestinal, y efectos significativos sobre el sistema músculo esquelético).Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are described. The compounds are amide compounds that can be prepared from certain heteroaryl carboxylic acids and certain diazabicycloalkanes. The compounds exhibit selectivity for, and binding with high affinity with, neuronal nicotinic receptors of the a4β2 subtype in the central nervous system (CNS). The compounds and compositions can be used to treat and / or avoid a wide variety of conditions or disorders, particularly CNS disorders. The compounds may: (i) alter the number of cholinergic nicotinic receptors in the patient's brain, (ii) exhibit neuroprotective effects, and (iii) when used in effective amounts, do not result in appreciable adverse side effects (for example side effects such such as significant increases in blood pressure and heart rate, significant negative effects on the gastrointestinal tract, and significant effects on the skeletal muscle system).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58607906P | 2006-11-02 | 2006-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP099377A true ECSP099377A (en) | 2009-07-31 |
Family
ID=41087117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP099377 ECSP099377A (en) | 2006-11-02 | 2009-06-01 | AMIDAS OF SELECTIVE DIAZABICICLOALCANS OF THE SUBTIPO OF THE NICOTINIC RECEIVER OF ACETILCOLINA |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP099377A (en) |
-
2009
- 2009-06-01 EC ECSP099377 patent/ECSP099377A/en unknown
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