ECSP099395A - Nuevos derivados de los ácidos amino-nicotínico y amino-isonicotínico - Google Patents

Nuevos derivados de los ácidos amino-nicotínico y amino-isonicotínico

Info

Publication number
ECSP099395A
ECSP099395A EC2009009395A ECSP099395A ECSP099395A EC SP099395 A ECSP099395 A EC SP099395A EC 2009009395 A EC2009009395 A EC 2009009395A EC SP099395 A ECSP099395 A EC SP099395A EC SP099395 A ECSP099395 A EC SP099395A
Authority
EC
Ecuador
Prior art keywords
halogen atoms
groups
optionally substituted
group
substituents selected
Prior art date
Application number
EC2009009395A
Other languages
English (en)
Inventor
Palomino Laria Julio Cesar Castro
Romero Eloisa Navarro
Sola Montserrat Erra
Toribio Maria Estrella Lozoya
Original Assignee
Almirall Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES200701086A external-priority patent/ES2327372B1/es
Application filed by Almirall Lab filed Critical Almirall Lab
Publication of ECSP099395A publication Critical patent/ECSP099395A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Un compuesto de fórmula (I) Formula (I)en donde:" uno de los grupos G1 representa un átomo de nitrógeno o un grupo CRc y el otro representa un grupo CRc" G2 representa un átomo de nitrógeno o un grupo CRd" R1 representa un grupo seleccionado de átomos de hidrógeno, átomos de halógeno, grupos alquilo C1-4 que pueden estar opcionalmente sustituidos con 1, 2 ó 3 sustituyentes seleccionados de átomos de halógeno y grupo hidroxi, y grupos cicloalquilo C3-8 que pueden estar opcionalmente sustituidos con 1, 2 ó 3 sustituyentes seleccionados de átomos de halógeno y grupo hidroxi" R2 representa un grupo seleccionado de átomos de hidrógeno, átomos de halógeno, grupos hidroxilo, grupos alquilo C1-4 que pueden estar opcionalmente sustituidos con 1, 2 ó 3 sustituyentes seleccionados de átomos de halógeno y grupo hidroxi, grupos alcoxi C1-4 que pueden estar opcionalmente sustituidos con 1, 2 ó 3 sustituyentes seleccionados de átomos de halógeno y grupo hidroxi, y grupos cicloalquilo C3-8 que pueden estar opcionalmente sustituidos con 1, 2 ó 3 sustituyentes seleccionados de átomos de halógeno y grupo hidroxi" Ra, Rb y Rc representan independientemente grupos seleccionado de átomos de hidrógeno, átomos de halógeno, grupos alquilo C1-4 que pueden estar opcionalmente sustituidos con 1, 2 ó 3 sustituyentes seleccionados de átomos de halógeno y grupo hidroxi, y grupos alcoxi C1-4 que pueden estar opcionalmente sustituidos con 1, 2 ó 3 sustituyentes seleccionados de átomos de halógeno y grupo hidroxi" Rd representa un grupo seleccionado de átomos de hidrógeno, átomos de halógeno, grupos hidroxilo, grupos alquilo C1-4 que pueden estar opcionalmente sustituidos con 1, 2 ó 3 sustituyentes seleccionados de átomos de halógeno y grupo hidroxi, y grupos alcoxi C1-4 que pueden estar opcionalmente sustituidos con 1, 2 ó 3 sustituyentes seleccionados de átomos de halógeno y grupo hidroxi, y grupos cicloalcoxi C3-8 que pueden estar opcionalmente sustituidos con 1, 2 ó 3 sustituyentes seleccionados de átomos de halógeno y grupo hidroxi" uno de los grupos G3 y G4 es un átomo de nitrógeno y el otro es un grupo CH, " M es un átomo de hidrógeno o un catión farmacéuticamente aceptable, con la condición de que, cuando al menos uno de los grupos Ra y Rb representa un átomo de hidrógeno y G2 es un grupo CRd, entonces Rd representa un grupo seleccionado de grupos alcoxi C1-4 que pueden estar opcionalmente sustituidos con 1, 2 ó 3 sustituyentes seleccionados de átomos de halógeno y grupo hidroxi, grupos cicloalcoxi C3-8 que pueden estar opcionalmente sustituidos con 1, 2 ó 3 sustituyentes seleccionados de átomos de halógeno y grupo hidroxi;y sus sales y N-óxidos farmacéuticamente aceptables.
EC2009009395A 2006-12-22 2009-06-09 Nuevos derivados de los ácidos amino-nicotínico y amino-isonicotínico ECSP099395A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200603250A ES2319596B1 (es) 2006-12-22 2006-12-22 Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
ES200701086A ES2327372B1 (es) 2007-04-23 2007-04-23 Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.

Publications (1)

Publication Number Publication Date
ECSP099395A true ECSP099395A (es) 2009-07-31

Family

ID=39319647

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009395A ECSP099395A (es) 2006-12-22 2009-06-09 Nuevos derivados de los ácidos amino-nicotínico y amino-isonicotínico

Country Status (31)

Country Link
US (2) US8258308B2 (es)
EP (1) EP2121614B1 (es)
JP (1) JP5318776B2 (es)
KR (1) KR101435233B1 (es)
CN (1) CN101589025B (es)
AR (1) AR064444A1 (es)
AU (1) AU2007338321B2 (es)
BR (1) BRPI0717697B1 (es)
CA (1) CA2674512C (es)
CL (1) CL2007003666A1 (es)
CY (1) CY1113687T1 (es)
DK (1) DK2121614T3 (es)
EC (1) ECSP099395A (es)
ES (2) ES2319596B1 (es)
HR (1) HRP20120697T1 (es)
IL (1) IL199188A (es)
ME (1) ME01475B (es)
MX (1) MX2009006408A (es)
MY (1) MY153393A (es)
NO (1) NO341991B1 (es)
NZ (1) NZ577017A (es)
PE (1) PE20081846A1 (es)
PL (1) PL2121614T3 (es)
PT (1) PT2121614E (es)
RS (1) RS52514B (es)
RU (1) RU2469024C2 (es)
SI (1) SI2121614T1 (es)
TW (1) TWI405572B (es)
UY (1) UY30794A1 (es)
WO (1) WO2008077639A1 (es)
ZA (1) ZA200903335B (es)

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