ECSP099634A - Derivados de piridazinona útiles como inhibidores de glucano sintasa - Google Patents

Derivados de piridazinona útiles como inhibidores de glucano sintasa

Info

Publication number
ECSP099634A
ECSP099634A EC2009009634A ECSP099634A ECSP099634A EC SP099634 A ECSP099634 A EC SP099634A EC 2009009634 A EC2009009634 A EC 2009009634A EC SP099634 A ECSP099634 A EC SP099634A EC SP099634 A ECSP099634 A EC SP099634A
Authority
EC
Ecuador
Prior art keywords
compounds
inhibitors
piridazinone
sintasa
glucano
Prior art date
Application number
EC2009009634A
Other languages
English (en)
Inventor
Robert Jason Herr
Rongze Kuang
Jianhua Cao
Pauline C Ting
Robert G Aslanian
David Won-Shik Kim
Gang Zhou
Andrew John Zych
Jinhai Yang
Heping Wu
Nicolas Zorn
Original Assignee
Schering Corp
Albany Molecular Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Albany Molecular Res Inc filed Critical Schering Corp
Publication of ECSP099634A publication Critical patent/ECSP099634A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

En sus muchas realizaciones, la presente invención provee compuestos sustituidos con estructura piridazinona como inhibidores de glucano sintasa, métodos para preparar dichos compuestos, composiciones farmacéuticas que incluyen uno o más de dichos compuestos, métodos para preparar formulaciones farmacéuticas que incluyen uno o más dichos compuestos o uno o más dichos compuestos junto con otros agentes anti-fúngicos, y métodos de tratamiento, prevención, inhibición, o alivio de una o más infecciones producidas por hongos asociados con glucano sintasa usando dichos compuestos o composiciones farmacéuticas.
EC2009009634A 2007-03-15 2009-09-14 Derivados de piridazinona útiles como inhibidores de glucano sintasa ECSP099634A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91817107P 2007-03-15 2007-03-15

Publications (1)

Publication Number Publication Date
ECSP099634A true ECSP099634A (es) 2009-10-30

Family

ID=39525788

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009634A ECSP099634A (es) 2007-03-15 2009-09-14 Derivados de piridazinona útiles como inhibidores de glucano sintasa

Country Status (18)

Country Link
US (1) US8232274B2 (es)
EP (2) EP2586778A3 (es)
JP (3) JP5147866B2 (es)
KR (1) KR20100049500A (es)
CN (1) CN101730692A (es)
AR (1) AR065721A1 (es)
AU (1) AU2008227100B2 (es)
BR (1) BRPI0809238A2 (es)
CA (1) CA2680583A1 (es)
CL (1) CL2008000725A1 (es)
CO (1) CO6220966A2 (es)
EC (1) ECSP099634A (es)
IL (1) IL200906A0 (es)
MX (1) MX2009009948A (es)
PE (1) PE20081882A1 (es)
RU (1) RU2009137946A (es)
TW (1) TW200902516A (es)
WO (1) WO2008115381A1 (es)

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JP5550352B2 (ja) 2007-03-15 2014-07-16 ノバルティス アーゲー 有機化合物およびその使用
AU2008302570B2 (en) * 2007-09-20 2012-05-31 Irm Llc Compounds and compositions as modulators of GPR119 activity
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
EP2627635A1 (en) * 2010-10-11 2013-08-21 Axikin Pharmaceuticals, Inc. Salts of arylsulfonamide ccr3 antagonists
FI20115234A0 (fi) 2011-03-08 2011-03-08 Biotie Therapies Corp Uusia pyridatsinoni- ja pyridoniyhdisteitä
GB201111705D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Compounds and their use
GB201111704D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Novel compounds
JO3115B1 (ar) * 2011-08-22 2017-09-20 Takeda Pharmaceuticals Co مركبات بيريدازينون واستخدامها كمثبطات daao
UA111861C2 (uk) 2011-11-15 2016-06-24 Такеда Фармасьютікал Компані Лімітед Ароматична гетероциклічна сполука дигідрокси
CN104379563B (zh) * 2012-04-10 2018-12-21 加利福尼亚大学董事会 用于治疗癌症的组合物和方法
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN103664795B (zh) * 2012-09-06 2017-10-03 华东理工大学 哒嗪酮类化合物及其用途
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
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CA3075727A1 (en) 2017-09-18 2019-03-21 Goldfinch Bio, Inc. Pyridazinones and methods of use thereof
CN109912476A (zh) * 2019-03-27 2019-06-21 南通宝凯化工有限公司 一种异丙氨基磺酰氯的生产工艺
CN112469713B (zh) * 2019-06-21 2023-09-01 江苏豪森药业集团有限公司 芳基磷氧化物类衍生物抑制剂、其制备方法和应用
US12509444B2 (en) * 2019-12-06 2025-12-30 Plexxikon Inc. Compounds and methods for CD73 modulation and indications therefor
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Also Published As

Publication number Publication date
PE20081882A1 (es) 2008-12-27
JP5147866B2 (ja) 2013-02-20
AR065721A1 (es) 2009-06-24
EP2586778A2 (en) 2013-05-01
AU2008227100A1 (en) 2008-09-25
EP2137179B1 (en) 2015-09-02
RU2009137946A (ru) 2011-04-20
IL200906A0 (en) 2010-05-17
WO2008115381A1 (en) 2008-09-25
TW200902516A (en) 2009-01-16
CL2008000725A1 (es) 2008-11-14
EP2137179A1 (en) 2009-12-30
AU2008227100B2 (en) 2014-01-09
JP2010521461A (ja) 2010-06-24
JP2013014622A (ja) 2013-01-24
JP2014051529A (ja) 2014-03-20
MX2009009948A (es) 2009-09-24
EP2586778A3 (en) 2013-07-31
US20090170861A1 (en) 2009-07-02
BRPI0809238A2 (pt) 2014-09-09
KR20100049500A (ko) 2010-05-12
CO6220966A2 (es) 2010-11-19
US8232274B2 (en) 2012-07-31
CA2680583A1 (en) 2008-09-25
CN101730692A (zh) 2010-06-09

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