ECSP099822A - Derivados de guanina policiclicos y sus métodos de uso - Google Patents

Derivados de guanina policiclicos y sus métodos de uso

Info

Publication number
ECSP099822A
ECSP099822A EC2009009822A ECSP099822A ECSP099822A EC SP099822 A ECSP099822 A EC SP099822A EC 2009009822 A EC2009009822 A EC 2009009822A EC SP099822 A ECSP099822 A EC SP099822A EC SP099822 A ECSP099822 A EC SP099822A
Authority
EC
Ecuador
Prior art keywords
guanine derivatives
methods
policycle
derivatives
polycyclic guanine
Prior art date
Application number
EC2009009822A
Other languages
English (en)
Inventor
Michael F Czarniecki
Deen Tulshian
Julius J Matasi
William B Geiss
Gregory S Martin
Van-Duc Le
James C Haber
Stephanie Nicole Cooke
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ECSP099822A publication Critical patent/ECSP099822A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a Derivados de Guanina Policíclicos, composiciones que comprenden los Derivados de Guanina Policíclicos y los métodos de uso de los Derivados de Guanina Policíclicos para tratar el dolor o una enfermedad inflamatoria.
EC2009009822A 2007-06-21 2009-12-21 Derivados de guanina policiclicos y sus métodos de uso ECSP099822A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94545207P 2007-06-21 2007-06-21

Publications (1)

Publication Number Publication Date
ECSP099822A true ECSP099822A (es) 2010-01-29

Family

ID=40186205

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009822A ECSP099822A (es) 2007-06-21 2009-12-21 Derivados de guanina policiclicos y sus métodos de uso

Country Status (17)

Country Link
US (1) US8349858B2 (es)
EP (1) EP2170896A2 (es)
JP (1) JP2010530427A (es)
KR (1) KR20100023040A (es)
AR (1) AR067060A1 (es)
AU (1) AU2008269177A1 (es)
BR (1) BRPI0812909A2 (es)
CA (1) CA2691194A1 (es)
CL (1) CL2008001835A1 (es)
CO (1) CO6251257A2 (es)
EC (1) ECSP099822A (es)
IL (1) IL202754A0 (es)
MX (1) MX2010000098A (es)
PE (1) PE20090418A1 (es)
RU (1) RU2010101611A (es)
TW (1) TW200911817A (es)
WO (1) WO2009002423A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2523561A4 (en) * 2009-12-22 2013-06-05 Merck Sharp & Dohme 7,8-DIHYDRO-1H-IMIDAZO [2,1-B] PURINE-4 (5H) -ONE DERIVATIVES AND METHOD OF USE
WO2012078448A1 (en) * 2010-12-06 2012-06-14 Schering Corporation Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors
TWI589576B (zh) 2011-07-15 2017-07-01 諾華公司 氮雜－雙環二芳基醚之鹽類及製造彼等或其前驅物之方法
MX341834B (es) * 2011-12-30 2016-09-05 Dow Agrosciences Llc Metodos de formacion de esteres pinacolicos de acido 4-cloro-2-fluoro-3-sustituido-fenilboronico y sus metodos de uso.
DK2948148T3 (da) * 2013-01-28 2020-10-26 Incozen Therapeutics Pvt Ltd Metoder til behandling af autoimmune, åndedræts- og betændelsesforstyrrelser ved inhalation af roflumilast n-oxid
TWI627174B (zh) 2013-03-14 2018-06-21 比利時商健生藥品公司 Ｐ２ｘ７調控劑
JP6294953B2 (ja) 2013-03-14 2018-03-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｐ２ｘ７調節物質
TWI644671B (zh) 2013-03-14 2018-12-21 比利時商健生藥品公司 Ｐ２ｘ７調節劑
WO2014152537A1 (en) * 2013-03-14 2014-09-25 Janssen Pharmaceutica Nv P2x7 modulators
EA201790600A1 (ru) 2014-09-12 2017-07-31 Янссен Фармацевтика Нв Модулирующие p2x7 n-ацил-триазолопиразины
JP6592510B2 (ja) 2014-09-12 2019-10-16 ヤンセン ファーマシューティカ エヌ．ベー． Ｐ２ｘ７調節因子
JP6358639B2 (ja) 2015-04-24 2018-07-18 塩野義製薬株式会社 ６員複素環誘導体およびそれらを含有する医薬組成物
MX393004B (es) * 2016-10-17 2025-03-24 Shionogi & Co Derivado heterociclico nitrogenado biciclico y composicion farmaceutica que lo contiene.
WO2020065614A1 (en) 2018-09-28 2020-04-02 Janssen Pharmaceutica Nv Monoacylglycerol lipase modulators
CN113164459B (zh) 2018-09-28 2024-09-03 詹森药业有限公司 单酰基甘油脂肪酶调节剂
ES3037365T3 (en) 2019-09-30 2025-10-01 Janssen Pharmaceutica Nv Radiolabelled mgl pet ligands
BR112022019077A2 (pt) 2020-03-26 2022-12-27 Janssen Pharmaceutica Nv Moduladores da monoacilglicerol lipase

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0119372A1 (en) 1983-03-21 1984-09-26 Svecia Silkscreen Maskiner AB Conveying device using a number of rollers
IL98559A0 (en) * 1990-06-21 1992-07-15 Schering Corp Polycyclic guanine derivatives
NZ262797A (en) * 1993-02-26 1997-08-22 Schering Corp Polycyclic guanine derivatives, purine and pyrimidine precursors; medicaments
EP0760850A1 (en) 1994-05-27 1997-03-12 Glaxo Group Limited P2x RECEPTORS (PURINOCEPTOR FAMILY)
US5856129A (en) 1996-10-30 1999-01-05 Incyte Pharmaceuticals, Inc. DNA encoding a human purinoceptor
WO1999055901A2 (en) 1998-04-30 1999-11-04 Abbott Laboratories Screening assay for identifying human purinoreceptor ligands
WO2002031508A1 (en) 2000-10-13 2002-04-18 Bristol-Myers Squibb Company Methods for detecting modulators of ion channels using thallium (i) sensitive assays
US20020182646A1 (en) 2001-04-30 2002-12-05 Ke Huazhu Methods and products for identifying modulators of P2X7 receptor activity, and their use in the treatment of skeletal disorders
ATE395349T1 (de) * 2001-08-28 2008-05-15 Schering Corp Polycyclische guanin phosphodiesterase inhibitoren
US20050238650A1 (en) 2002-04-17 2005-10-27 Genentech, Inc. Compositions and methods for the treatment of tumor of hematopoietic origin
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
CA2465893A1 (en) * 2001-11-09 2003-05-22 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
US7560243B2 (en) 2003-04-21 2009-07-14 Wisconsin Alumni Research Foundation White blood cell functional assay
GB0323147D0 (en) 2003-10-03 2003-11-05 Medical Res Council Improvements in or relating to concentration of intracellular agents
EP2305258A3 (en) 2005-05-31 2011-07-06 Duska Scientific Co Inhibition of neuronal damage
WO2007115192A2 (en) 2006-03-31 2007-10-11 Abbott Laboratories P2x7 antagonists to treat affective disorders

Also Published As

Publication number Publication date
AU2008269177A1 (en) 2008-12-31
TW200911817A (en) 2009-03-16
BRPI0812909A2 (pt) 2014-12-09
JP2010530427A (ja) 2010-09-09
WO2009002423A3 (en) 2009-04-23
EP2170896A2 (en) 2010-04-07
WO2009002423A2 (en) 2008-12-31
MX2010000098A (es) 2010-04-21
US20110065738A1 (en) 2011-03-17
KR20100023040A (ko) 2010-03-03
US8349858B2 (en) 2013-01-08
RU2010101611A (ru) 2011-07-27
CA2691194A1 (en) 2008-12-31
PE20090418A1 (es) 2009-04-18
CO6251257A2 (es) 2011-02-21
IL202754A0 (en) 2010-06-30
CL2008001835A1 (es) 2008-12-26
AR067060A1 (es) 2009-09-30

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