ECSP10010499A - PROCESS FOR THE PREPARATION OF BENZOFUSED HETEROARILO SULFAMATES AND THE CRYSTALLINE FORM OF N - (((2S) -6-CHLORINE-2,3-DIHYDRO-1,4-BENZODIOXIN-2IL) METHYL-SULFAMIDE - Google Patents

PROCESS FOR THE PREPARATION OF BENZOFUSED HETEROARILO SULFAMATES AND THE CRYSTALLINE FORM OF N - (((2S) -6-CHLORINE-2,3-DIHYDRO-1,4-BENZODIOXIN-2IL) METHYL-SULFAMIDE

Info

Publication number
ECSP10010499A
ECSP10010499A EC2010010499A ECSP10010499A ECSP10010499A EC SP10010499 A ECSP10010499 A EC SP10010499A EC 2010010499 A EC2010010499 A EC 2010010499A EC SP10010499 A ECSP10010499 A EC SP10010499A EC SP10010499 A ECSP10010499 A EC SP10010499A
Authority
EC
Ecuador
Prior art keywords
preparation
sulfamates
benzofused
heteroarilo
benzodioxin
Prior art date
Application number
EC2010010499A
Other languages
Spanish (es)
Inventor
Ahmed F Abdel-Magid
Steven J Mehrman
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP10010499A publication Critical patent/ECSP10010499A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/04—Seven-membered rings not condensed with other rings
    • C07D321/08—1,4-Dioxepines; Hydrogenated 1,4-dioxepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se dirige a un proceso para la preparación de sulfamatos de heteroarilo benzofusionado, útiles para el tratamiento de epilepsia y trastornos relacionados, de conformidad con la Fórmula (IA) y con un compuesto cristalino de la Fórmula (I-S).Proceso para la preparación de un compuesto de Fórmula (IA).The present invention is directed to a process for the preparation of benzofused heteroaryl sulfamates, useful for the treatment of epilepsy and related disorders, in accordance with Formula (IA) and with a crystalline compound of Formula (IS). Preparation of a compound of Formula (IA).

EC2010010499A 2008-03-26 2010-09-24 PROCESS FOR THE PREPARATION OF BENZOFUSED HETEROARILO SULFAMATES AND THE CRYSTALLINE FORM OF N - (((2S) -6-CHLORINE-2,3-DIHYDRO-1,4-BENZODIOXIN-2IL) METHYL-SULFAMIDE ECSP10010499A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/058233 WO2009120191A1 (en) 2008-03-26 2008-03-26 Process for the preparation of benzo-fused heteroaryl sulfamates and crystalline form of n- ( ( (2s) -6-chloro-2,3-dihydro-l,4-benzodioxin-2-yl) methyl-sulfamide

Publications (1)

Publication Number Publication Date
ECSP10010499A true ECSP10010499A (en) 2010-10-30

Family

ID=40030223

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010499A ECSP10010499A (en) 2008-03-26 2010-09-24 PROCESS FOR THE PREPARATION OF BENZOFUSED HETEROARILO SULFAMATES AND THE CRYSTALLINE FORM OF N - (((2S) -6-CHLORINE-2,3-DIHYDRO-1,4-BENZODIOXIN-2IL) METHYL-SULFAMIDE

Country Status (14)

Country Link
EP (1) EP2280950A1 (en)
JP (1) JP2011515464A (en)
KR (1) KR20100126535A (en)
CN (1) CN101981019A (en)
AU (1) AU2008353491A1 (en)
BR (1) BRPI0822454A2 (en)
CA (1) CA2719624A1 (en)
CR (1) CR11761A (en)
EA (1) EA201071120A1 (en)
EC (1) ECSP10010499A (en)
IL (1) IL208222A0 (en)
MX (1) MX2010010595A (en)
WO (1) WO2009120191A1 (en)
ZA (1) ZA201007611B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
MX2007014613A (en) 2005-05-20 2008-04-02 Johnson & Johnson Process for preparation of sulfamide derivatives.
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
WO2007137167A2 (en) 2006-05-19 2007-11-29 Janssen Pharmaceutica N.V. Co-therapy for the treatment of epilepsy
AU2009271362B2 (en) * 2008-06-23 2014-03-13 Janssen Pharmaceutica Nv Crystalline form of (2s)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide
US8815939B2 (en) 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
CN107954906B (en) * 2017-11-24 2020-10-16 西北师范大学 A kind of synthetic method of arylsulfonyl tertiary amine compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513006A (en) * 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
AR049646A1 (en) * 2004-06-16 2006-08-23 Janssen Pharmaceutica Nv USEFUL SULFAMATE AND SULFAMIDE DERIVATIVES FOR THE TREATMENT OF EPILEPSY AND RELATED DISORDERS
MX2007002309A (en) * 2004-08-24 2007-10-08 Johnson & Johnson Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents.
TW200738669A (en) * 2006-02-22 2007-10-16 Janssen Pharmaceutica Nv Crystalline forms of N-(benzo[b]thien-3-ylmethyl)-sulfamide

Also Published As

Publication number Publication date
ZA201007611B (en) 2012-04-25
CN101981019A (en) 2011-02-23
WO2009120191A1 (en) 2009-10-01
CA2719624A1 (en) 2009-10-01
IL208222A0 (en) 2010-12-30
CR11761A (en) 2011-07-06
MX2010010595A (en) 2010-10-25
EP2280950A1 (en) 2011-02-09
KR20100126535A (en) 2010-12-01
BRPI0822454A2 (en) 2015-06-16
EA201071120A1 (en) 2011-06-30
JP2011515464A (en) 2011-05-19
AU2008353491A1 (en) 2009-10-01

Similar Documents

Publication Publication Date Title
ECSP10010499A (en) PROCESS FOR THE PREPARATION OF BENZOFUSED HETEROARILO SULFAMATES AND THE CRYSTALLINE FORM OF N - (((2S) -6-CHLORINE-2,3-DIHYDRO-1,4-BENZODIOXIN-2IL) METHYL-SULFAMIDE
ECSP10010498A (en) PROCESSES FOR THE PREPARATION OF BENZOFUSED HETEROARILO DERIVATIVES
BRPI0810198A2 (en) PROCESS TO PRODUCE AMIDE COMPOUND
EP2397459A4 (en) PROCESS FOR PRODUCING PHENYLACETAMIDE COMPOUND
JP2013540893A5 (en)
BRPI1013426A2 (en) organisms for the production of 1,3-butanediol
TN2010000539A1 (en) Salts and polymorphs of a tetracylcline compound
EP2508655A4 (en) PROCESS FOR THE PRODUCTION OF MONOCRYSTALS OF SILICON CARBIDE
BRPI0905147A8 (en) process for synthesizing ivabradine and its addition salts with a pharmaceutically acceptable acid
AR061311A1 (en) PROCESSES TO PREPARE CINACALCET CHLORHYDRATE AND POLYMORPHIC FORMS OF THE SAME
CR20160465A (en) POLYMORPH B OF THE N- (2-AMINOPHENYL) -4- [N- (PIRIDIN-3-IL) METOXICARBONYLAMINE-METHYL] BENZAMIDE (MS-275)
CL2008002532A1 (en) Synthesis process of a pyrido- [2,1-a] isoquinoline derivative; crystalline forms of said compounds; and its use to treat diabetes, diabetes mellitus, glucose intolerance disorder.
CL2012003371A1 (en) Intermediate compounds of agomelatine synthesis; and the process for obtaining agomelatine from said intermediary compounds
EA201170481A1 (en) SKIN CRYSTALS
EP2441514A4 (en) AMMOXIDATION CATALYST AND PROCESS FOR PRODUCING NITRILE COMPOUND USING THE SAME
BR112012009611A2 (en) '' process for the preparation of a compound of formula (i) ''
BRPI1007718A2 (en) process for the production of sodium cyanide crystals
GT200900215A (en) NEW PROCEDURE FOR OBTAINING THE CRYSTALLINE V FORM OF AGOMELATINE.
AR058253A1 (en) PROCEDURE FOR THE PREPARATION OF FERRI-SUCCINILCASEINA
CL2012000270A1 (en) Preparation procedure of ivabradine and its addition salts by formation of the benzoacepine ring; and the intermediary compounds considered in the process.
CO6390054A2 (en) CRYSTAL FORMS OF A 3-CARBOXIPROPIL-AMINOTETRALINE COMPOUND
EP2428501A4 (en) DIARYLIODONIUM SALT MIXTURE AND PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING DIARYLIODONIUM COMPOUND
CO6290652A2 (en) PROCESS FOR THE PREPARATION OF BENZOFUSED HETEROARILO SULFAMATES AND THE CRYSTAL FORM OF N - (((2S) -6-CHLORINE-2,3-DIHYDRO-1,4BENZODIOXIN-2IL) METHYL-SULFAMIDE
AR064215A1 (en) PROCESS FOR OBTAINING R-ENANTIOMERO DE SALBUTAMOL
MA35362B1 (en) New crystal form