ECSP10010577A - Antagonistas de la trayectoria hedgehog de ftalazina disustituida - Google Patents

Antagonistas de la trayectoria hedgehog de ftalazina disustituida

Info

Publication number
ECSP10010577A
ECSP10010577A EC2010010577A ECSP10010577A ECSP10010577A EC SP10010577 A ECSP10010577 A EC SP10010577A EC 2010010577 A EC2010010577 A EC 2010010577A EC SP10010577 A ECSP10010577 A EC SP10010577A EC SP10010577 A ECSP10010577 A EC SP10010577A
Authority
EC
Ecuador
Prior art keywords
antagonists
hedgehog
ftalazina
disttituted
trajectory
Prior art date
Application number
EC2010010577A
Other languages
English (en)
Inventor
Philip Arthur Hipsikind
Takako Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ECSP10010577A publication Critical patent/ECSP10010577A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a nuevos antagonistas de la trayectoria de hedgehog de ftalazina 1,4-disustituida, ·tiles en el tratamiento de cancer.
EC2010010577A 2008-04-29 2010-10-27 Antagonistas de la trayectoria hedgehog de ftalazina disustituida ECSP10010577A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4872908P 2008-04-29 2008-04-29

Publications (1)

Publication Number Publication Date
ECSP10010577A true ECSP10010577A (es) 2010-11-30

Family

ID=40846962

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010577A ECSP10010577A (es) 2008-04-29 2010-10-27 Antagonistas de la trayectoria hedgehog de ftalazina disustituida

Country Status (22)

Country Link
US (1) US7981892B2 (es)
EP (1) EP2294061A2 (es)
JP (1) JP5442717B2 (es)
KR (1) KR101260116B1 (es)
CN (1) CN102066353B (es)
AU (1) AU2009241561B2 (es)
BR (1) BRPI0911618A2 (es)
CA (1) CA2723042A1 (es)
CO (1) CO6300945A2 (es)
CR (1) CR11741A (es)
DO (1) DOP2010000302A (es)
EA (1) EA201071248A1 (es)
EC (1) ECSP10010577A (es)
HN (1) HN2010002157A (es)
IL (1) IL208211A0 (es)
MA (1) MA32349B1 (es)
MX (1) MX2010011948A (es)
MY (1) MY159491A (es)
NZ (1) NZ588001A (es)
UA (1) UA102250C2 (es)
WO (1) WO2009134574A2 (es)
ZA (1) ZA201006695B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA102250C2 (ru) 2008-04-29 2013-06-25 Эли Лилли Энд Компани Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
MX2011004683A (es) 2008-11-03 2011-06-20 Lilly Co Eli Antagonistas de la via hedgehog de ftalazina disustituida.
KR101342184B1 (ko) 2008-11-17 2013-12-19 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
BRPI0921777A2 (pt) 2008-11-17 2016-01-12 Lilly Co Eli antagonistas da via hedgehog de piridazina tetrassubstituída
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
KR20120107962A (ko) * 2009-11-18 2012-10-04 노파르티스 아게 고형 종양 및 다른 악성종양의 치료를 위한 방법 및 조성물
CN102702108A (zh) * 2012-06-27 2012-10-03 上海大学 1,2-二氢酞嗪类化合物及其合成方法
WO2014043608A2 (en) * 2012-09-17 2014-03-20 Duke University Smoothened modulators and methods of use thereof
CN102863393A (zh) * 2012-09-26 2013-01-09 上海大学 1,2-二氢酞嗪类化合物及其合成方法
GB201309508D0 (en) * 2013-05-28 2013-07-10 Redx Pharma Ltd Compounds
GB2528298A (en) * 2014-07-16 2016-01-20 Redx Pharma Plc Compounds
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN107163028B (zh) * 2017-05-24 2019-07-12 东南大学 一种苯甲酰胺类Hedgehog抑制剂及其制备方法和应用
US12605377B2 (en) 2020-10-13 2026-04-21 Endeavor Biomedicines, Inc. Methods of treating fibrosis
JP2023546536A (ja) 2020-10-13 2023-11-02 エンデバー バイオメディシンズ， インコーポレイテッド 線維症を処置する方法
IL319619A (en) * 2022-09-23 2025-05-01 Merck Sharp & Dohme Llc Phthalazine derivatives used as NOD-LIKE PROTEIN 3 receptor inhibitors
WO2025188802A1 (en) 2024-03-05 2025-09-12 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
MY117098A (en) * 1996-01-15 2004-05-31 Janssen Pharmaceutica Nv Angiogenesis inhibiting pyridazinamines
US6432970B2 (en) * 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
JP5067986B2 (ja) 1998-04-09 2012-11-07 ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用
ATE283700T1 (de) 1999-06-08 2004-12-15 Lorantis Ltd Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges
EP1496905B1 (en) 2002-04-22 2008-08-13 Johns Hopkins University School of Medicine Modulators of hedgehog signaling pathways, compositions and uses related thereto
WO2004020599A2 (en) 2002-08-29 2004-03-11 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
TW200533356A (en) 2004-02-24 2005-10-16 Mitsubishi Pharma Corp Fused pyridazine derivatives
WO2006004589A2 (en) 2004-05-08 2006-01-12 Neurogen Corporation 3-aryl-5,6-disubstituted pyridazines
ES2377430T3 (es) 2004-09-02 2012-03-27 Genentech, Inc. Inhibidores piridílicos de la señalización de hedgehog
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
CA2681162C (en) 2007-03-15 2015-11-24 Novartis Ag Benzyl and pyridine derivatives as modulators of hedgehog pathway
US8153633B2 (en) * 2007-06-25 2012-04-10 Amgen Inc. Phthalazine compounds, compositions and methods of use
US8222251B2 (en) 2007-09-07 2012-07-17 Amgen Inc. Pyridopyridazine compounds, compositions and methods of use
UA102250C2 (ru) 2008-04-29 2013-06-25 Эли Лилли Энд Компани Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
MX2011004683A (es) 2008-11-03 2011-06-20 Lilly Co Eli Antagonistas de la via hedgehog de ftalazina disustituida.
BRPI0921777A2 (pt) 2008-11-17 2016-01-12 Lilly Co Eli antagonistas da via hedgehog de piridazina tetrassubstituída
KR101342184B1 (ko) 2008-11-17 2013-12-19 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
CA2723042A1 (en) 2009-11-05
CR11741A (es) 2011-01-05
EA201071248A1 (ru) 2011-06-30
MX2010011948A (es) 2010-12-14
MY159491A (en) 2017-01-13
CN102066353B (zh) 2013-12-11
AU2009241561A1 (en) 2009-11-05
CN102066353A (zh) 2011-05-18
US7981892B2 (en) 2011-07-19
NZ588001A (en) 2012-06-29
UA102250C2 (ru) 2013-06-25
JP2011527666A (ja) 2011-11-04
EP2294061A2 (en) 2011-03-16
WO2009134574A3 (en) 2014-09-04
KR101260116B1 (ko) 2013-05-02
WO2009134574A2 (en) 2009-11-05
US20110046143A1 (en) 2011-02-24
HN2010002157A (es) 2014-09-08
ZA201006695B (en) 2012-09-26
CO6300945A2 (es) 2011-07-21
KR20100126580A (ko) 2010-12-01
AU2009241561B2 (en) 2013-05-16
DOP2010000302A (es) 2010-11-15
MA32349B1 (fr) 2011-06-01
IL208211A0 (en) 2010-12-30
JP5442717B2 (ja) 2014-03-12
BRPI0911618A2 (pt) 2019-09-24

Similar Documents

Publication Publication Date Title
ECSP10010577A (es) Antagonistas de la trayectoria hedgehog de ftalazina disustituida
DOP2011000386A (es) Antagonistas de la trayectoria hedgehog de ftalazina disustituida
CO6382123A2 (es) Antagonistas de la via hedgehog de ftalazina disustituida
EA200801758A1 (ru) Лекарственные формы, устойчивые к самовольному изменению
HN2011002809A (es) Compuestos de vinil indazolilo
CL2009000402A1 (es) Compuestos derivados de 2-amino-acetamida sustituida; composicion farmaceutica; utiles en el tratamiento de enfermedades pulmonares, enfermedad reumatica, enfermedad autoinmune, entre otras.
CR9947A (es) Compuestos de pirimidinil benzotiofeno
DOP2012000038A (es) Conjugados de dímeros de pirrolo [1,4] benzodiazepina como agentes anticancerosos
MX2019015200A (es) Compuestos de diarilhidantoina.
UY31484A1 (es) Piperidinas heteroaril-sustituidas
LT3492069T (lt) Farmacinės kompozicijos, apimančios geležies oksihidroksidą
CR11423A (es) NUEVOS INHIBIDORES DE sEH Y SU USO
CR9344S (es) Regadera
CL2008000629A1 (es) Compuestos macrociclicos derivados de 6-aril-4-mercapto-[1.3.5]triazina/[1.3]pirimidin-2-amina; composicion farmaceutica, utiles en el tratamiento del cancer.
DOP2005000025A (es) Compuestos de heteroaril- y fenilsulfamoilo sustituidos
PA8784301A1 (es) Oxazolidinonas sustituidas y su uso
CR11332A (es) Co-cristales de pirimetanilo y ditianona
CU24011B1 (es) Piperidinas 2-fenil-5-(1,2,4-oxadiazol-5-il) sustituidas
EA200971067A1 (ru) Триазолиламинопиримидиновые соединения
MX2013006185A (es) Compuestos de 6-(piridinilmetoxi) -pirrolopiridina 3-sustituidos.
FR2911479B1 (fr) Ensemble de vetements.
TN2010000489A1 (en) Disubstituted phthalazine hedgehog pathway antagonists
CY1114078T1 (el) Ανταγωνιστες διυποκατεστημενης φθαλαζινης του μονοπατιου hedgehog
AU323946S (en) Tumbler
AU317058S (en) Concrete pavers