ECSP10010577A - Antagonistas de la trayectoria hedgehog de ftalazina disustituida - Google Patents

Antagonistas de la trayectoria hedgehog de ftalazina disustituida

Info

Publication number
ECSP10010577A
ECSP10010577A EC2010010577A ECSP10010577A ECSP10010577A EC SP10010577 A ECSP10010577 A EC SP10010577A EC 2010010577 A EC2010010577 A EC 2010010577A EC SP10010577 A ECSP10010577 A EC SP10010577A EC SP10010577 A ECSP10010577 A EC SP10010577A
Authority
EC
Ecuador
Prior art keywords
antagonists
hedgehog
ftalazina
disttituted
trajectory
Prior art date
Application number
EC2010010577A
Other languages
English (en)
Inventor
Philip Arthur Hipsikind
Takako Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ECSP10010577A publication Critical patent/ECSP10010577A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a nuevos antagonistas de la trayectoria de hedgehog de ftalazina 1,4-disustituida, ·tiles en el tratamiento de cancer.
EC2010010577A 2008-04-29 2010-10-27 Antagonistas de la trayectoria hedgehog de ftalazina disustituida ECSP10010577A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4872908P 2008-04-29 2008-04-29

Publications (1)

Publication Number Publication Date
ECSP10010577A true ECSP10010577A (es) 2010-11-30

Family

ID=40846962

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010577A ECSP10010577A (es) 2008-04-29 2010-10-27 Antagonistas de la trayectoria hedgehog de ftalazina disustituida

Country Status (22)

Country Link
US (1) US7981892B2 (es)
EP (1) EP2294061A2 (es)
JP (1) JP5442717B2 (es)
KR (1) KR101260116B1 (es)
CN (1) CN102066353B (es)
AU (1) AU2009241561B2 (es)
BR (1) BRPI0911618A2 (es)
CA (1) CA2723042A1 (es)
CO (1) CO6300945A2 (es)
CR (1) CR11741A (es)
DO (1) DOP2010000302A (es)
EA (1) EA201071248A1 (es)
EC (1) ECSP10010577A (es)
HN (1) HN2010002157A (es)
IL (1) IL208211A0 (es)
MA (1) MA32349B1 (es)
MX (1) MX2010011948A (es)
MY (1) MY159491A (es)
NZ (1) NZ588001A (es)
UA (1) UA102250C2 (es)
WO (1) WO2009134574A2 (es)
ZA (1) ZA201006695B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201071248A1 (ru) 2008-04-29 2011-06-30 Эли Лилли Энд Компани Дизамещенные фталазиновые антагонисты пути hedgehog
NZ591945A (en) 2008-11-03 2012-10-26 Lilly Co Eli Disubstituted phthalazine hedgehog pathway antagonists
AU2009314288B2 (en) * 2008-11-17 2013-05-02 Eli Lilly And Company Tetrasubstituted pyridazines hedgehog pathway antagonists
BRPI0921782A2 (pt) 2008-11-17 2019-09-24 Lilly Co Eli antagonistas da via hedgehog de piridazina tetrassubstituída
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
BR112012011823A2 (pt) * 2009-11-18 2019-09-24 Novartis Ag métodos e composições para tratar tumores sólidos e outras malignidades
CN102702108A (zh) * 2012-06-27 2012-10-03 上海大学 1,2-二氢酞嗪类化合物及其合成方法
EP2895474B1 (en) * 2012-09-17 2019-12-11 Duke University Smoothened receptor modulators and methods of use thereof
CN102863393A (zh) * 2012-09-26 2013-01-09 上海大学 1,2-二氢酞嗪类化合物及其合成方法
GB201309508D0 (en) 2013-05-28 2013-07-10 Redx Pharma Ltd Compounds
GB2528298A (en) * 2014-07-16 2016-01-20 Redx Pharma Plc Compounds
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN107163028B (zh) * 2017-05-24 2019-07-12 东南大学 一种苯甲酰胺类Hedgehog抑制剂及其制备方法和应用
WO2022081661A1 (en) 2020-10-13 2022-04-21 Endeavor Biomedicines, Inc. Methods of treating fibrosis
IL319619A (en) * 2022-09-23 2025-05-01 Merck Sharp & Dohme Llc Phthalazine derivatives used as NOD-LIKE PROTEIN 3 receptor inhibitors
WO2025188802A1 (en) 2024-03-05 2025-09-12 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
CA2237273C (en) * 1996-01-15 2009-01-13 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
US6432970B2 (en) * 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
EP1067939B1 (en) 1998-04-09 2015-09-16 The Johns Hopkins University Use of steroidal alkaloid derivatives as inhibitors of hedgehog protein signaling pathways
GB0013674D0 (en) 1999-06-08 2000-07-26 Lorantis Ltd Therapeutic use
ATE404200T1 (de) 2002-04-22 2008-08-15 Univ Johns Hopkins Med Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen
WO2004020599A2 (en) 2002-08-29 2004-03-11 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
TW200533356A (en) 2004-02-24 2005-10-16 Mitsubishi Pharma Corp Fused pyridazine derivatives
US8338591B2 (en) 2004-05-08 2012-12-25 Novartis International Pharmaceutical Ltd. 3-aryl-5,6-disubstituted pyridazines
KR20170001725A (ko) 2004-09-02 2017-01-04 제넨테크, 인크. 헤지호그 신호전달에 대한 피리딜 억제제
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
JP5550352B2 (ja) 2007-03-15 2014-07-16 ノバルティス アーゲー 有機化合物およびその使用
AU2008269128B2 (en) * 2007-06-25 2012-08-02 Amgen Inc. Phthalazine compounds, compositions and methods of use
WO2009035568A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling
EA201071248A1 (ru) 2008-04-29 2011-06-30 Эли Лилли Энд Компани Дизамещенные фталазиновые антагонисты пути hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
NZ591945A (en) 2008-11-03 2012-10-26 Lilly Co Eli Disubstituted phthalazine hedgehog pathway antagonists
BRPI0921782A2 (pt) 2008-11-17 2019-09-24 Lilly Co Eli antagonistas da via hedgehog de piridazina tetrassubstituída
AU2009314288B2 (en) 2008-11-17 2013-05-02 Eli Lilly And Company Tetrasubstituted pyridazines hedgehog pathway antagonists
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
CN102066353A (zh) 2011-05-18
JP2011527666A (ja) 2011-11-04
AU2009241561A1 (en) 2009-11-05
ZA201006695B (en) 2012-09-26
WO2009134574A2 (en) 2009-11-05
CR11741A (es) 2011-01-05
BRPI0911618A2 (pt) 2019-09-24
JP5442717B2 (ja) 2014-03-12
CA2723042A1 (en) 2009-11-05
HN2010002157A (es) 2014-09-08
KR101260116B1 (ko) 2013-05-02
NZ588001A (en) 2012-06-29
CN102066353B (zh) 2013-12-11
AU2009241561B2 (en) 2013-05-16
IL208211A0 (en) 2010-12-30
KR20100126580A (ko) 2010-12-01
DOP2010000302A (es) 2010-11-15
US7981892B2 (en) 2011-07-19
CO6300945A2 (es) 2011-07-21
MX2010011948A (es) 2010-12-14
US20110046143A1 (en) 2011-02-24
WO2009134574A3 (en) 2014-09-04
MA32349B1 (fr) 2011-06-01
UA102250C2 (ru) 2013-06-25
EP2294061A2 (en) 2011-03-16
MY159491A (en) 2017-01-13
EA201071248A1 (ru) 2011-06-30

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