ECSP10010601A - Ligandos de receptor de estrogeno novedosos - Google Patents

Ligandos de receptor de estrogeno novedosos

Info

Publication number
ECSP10010601A
ECSP10010601A EC2010010601A ECSP10010601A ECSP10010601A EC SP10010601 A ECSP10010601 A EC SP10010601A EC 2010010601 A EC2010010601 A EC 2010010601A EC SP10010601 A ECSP10010601 A EC SP10010601A EC SP10010601 A ECSP10010601 A EC SP10010601A
Authority
EC
Ecuador
Prior art keywords
strogen
new
receiver links
carbamate
amide
Prior art date
Application number
EC2010010601A
Other languages
English (en)
Inventor
Aiping Cheng
Patrik P Rhinnstad
Theresa Apelqvist
Elisabet Kallin
Mattias Wennerstal
Original Assignee
Karo Bio A B
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0806944A external-priority patent/GB0806944D0/en
Priority claimed from GB0823367A external-priority patent/GB0823367D0/en
Application filed by Karo Bio A B filed Critical Karo Bio A B
Publication of ECSP10010601A publication Critical patent/ECSP10010601A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
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  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
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Abstract

La invencion proporciona un compuesto de la formula (I) o un ester, amida, carbamato, solvato o sal del mismo farmaceuticamente aceptable, incluyendo una sal de tal ester, amida o carbamato, y un solvato de tal ester, amida, carbamato o sal. La invencion proporciona tambien el uso de tales compuestos en el tratamiento o profilaxis de una condicion asociada con una enfermedad o trastorno asociados con actividad de receptor de estrogeno, en donde R1, R2, R3, R4, R5 y R6 son como se definen en la especificacion.
EC2010010601A 2008-04-16 2010-11-10 Ligandos de receptor de estrogeno novedosos ECSP10010601A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0806944A GB0806944D0 (en) 2008-04-16 2008-04-16 Novel estrogen receptor ligands
GB0823367A GB0823367D0 (en) 2008-12-22 2008-12-22 Novel Estrogen Receptor Ligands

Publications (1)

Publication Number Publication Date
ECSP10010601A true ECSP10010601A (es) 2010-12-30

Family

ID=40673672

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010601A ECSP10010601A (es) 2008-04-16 2010-11-10 Ligandos de receptor de estrogeno novedosos

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US (2) US8367665B2 (es)
EP (1) EP2276732B1 (es)
JP (1) JP5635493B2 (es)
KR (2) KR20160067981A (es)
CN (1) CN102066323B (es)
AU (1) AU2009237657B2 (es)
BR (1) BRPI0910656A2 (es)
CA (1) CA2720215C (es)
CO (1) CO6311077A2 (es)
CY (1) CY1116741T1 (es)
DK (1) DK2276732T3 (es)
EC (1) ECSP10010601A (es)
ES (1) ES2543599T3 (es)
HR (1) HRP20150864T1 (es)
HU (1) HUE025471T2 (es)
IL (1) IL208392A (es)
MX (1) MX2010011408A (es)
NZ (1) NZ588121A (es)
PL (1) PL2276732T3 (es)
PT (1) PT2276732E (es)
RS (1) RS54165B1 (es)
RU (1) RU2492164C2 (es)
SI (1) SI2276732T1 (es)
WO (1) WO2009127686A1 (es)
ZA (1) ZA201007255B (es)

Families Citing this family (27)

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IN2012DN02556A (es) 2009-10-07 2015-08-28 Karobio Ab
ES2744219T3 (es) 2009-10-07 2020-02-24 Karo Pharma Ab Ligandos del receptor de estrógeno
US20130045992A1 (en) 2010-01-28 2013-02-21 President And Fellows Of Harvard College Compositions and Methods for Enhancing Proteasome Activity
CA2789757A1 (en) * 2010-02-17 2011-08-25 Janssen Pharmaceutica Nv Aminothiazolones as estrogen related receptor-alpha modulators
AU2011248175A1 (en) * 2010-05-06 2012-10-25 Merck Sharp & Dohme Corp. Aza-Indole derivatives useful as modulators of FAAH
GB201105979D0 (en) * 2011-04-07 2011-05-18 Karobio Ab Novel estrogen receptor ligands
WO2012154967A1 (en) * 2011-05-12 2012-11-15 Proteostasis Therapeutics, Inc. Proteostasis regulators
GB201113538D0 (en) * 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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