ECSP10010607A - 2,6-DIAMINO-PYRIMIDIN-5-IL-CARBOXAMIDS AS SYK OR JAK KINASAS INHIBITORS - Google Patents
2,6-DIAMINO-PYRIMIDIN-5-IL-CARBOXAMIDS AS SYK OR JAK KINASAS INHIBITORSInfo
- Publication number
- ECSP10010607A ECSP10010607A EC2010010607A ECSP10010607A ECSP10010607A EC SP10010607 A ECSP10010607 A EC SP10010607A EC 2010010607 A EC2010010607 A EC 2010010607A EC SP10010607 A ECSP10010607 A EC SP10010607A EC SP10010607 A ECSP10010607 A EC SP10010607A
- Authority
- EC
- Ecuador
- Prior art keywords
- syk
- jak
- inhibitors
- kinasas
- carboxamids
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 102000042838 JAK family Human genes 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 102000015617 Janus Kinases Human genes 0.000 abstract 1
- 108010024121 Janus Kinases Proteins 0.000 abstract 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 abstract 1
- 102000000551 Syk Kinase Human genes 0.000 abstract 1
- 108010016672 Syk Kinase Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se dirige a compuestos de la Fórmula I-II y tautómeros, sales o estereoisómeros farmacéuticamente aceptables de la misma que son inhibidores de syk y/o JAK quinasas. La presente invención también se dirige a intermediarios usados para realizar dichos compuestos, a la preparación de dicho compuesto, composiciones farmacéuticas que contienen dicho compuesto, métodos de inhibición de syk y/o JAK quinasa, métodos para la inhibición de agregación de plaquetas, y métodos para evitar o tratar una cantidad de enfermedaddes mediadas, al menos en parte, por la actividad syk y/o JAK quinasa, como por ejemplo trombosis y Linfoma no- Hodgkin.The present invention is directed to compounds of Formula I-II and pharmaceutically acceptable tautomers, salts or stereoisomers thereof which are inhibitors of syk and / or JAK kinases. The present invention is also directed to intermediates used to make said compounds, to the preparation of said compound, pharmaceutical compositions containing said compound, methods of inhibition of syk and / or JAK kinase, methods for inhibition of platelet aggregation, and methods to avoid or treat a number of diseases mediated, at least in part, by the syk and / or JAK kinase activity, such as thrombosis and non-Hodgkin lymphoma.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4539908P | 2008-04-16 | 2008-04-16 | |
| US4541708P | 2008-04-16 | 2008-04-16 | |
| US4540608P | 2008-04-16 | 2008-04-16 | |
| US12034108P | 2008-12-05 | 2008-12-05 | |
| US12034808P | 2008-12-05 | 2008-12-05 | |
| PCT/US2009/002420 WO2009145856A1 (en) | 2008-04-16 | 2009-04-16 | 2, 6-diamino-pyrimidin- 5-yl-carboxamides as syk or jak kinases inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP10010607A true ECSP10010607A (en) | 2011-02-28 |
Family
ID=44279986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2010010607A ECSP10010607A (en) | 2008-04-16 | 2010-11-15 | 2,6-DIAMINO-PYRIMIDIN-5-IL-CARBOXAMIDS AS SYK OR JAK KINASAS INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP10010607A (en) |
-
2010
- 2010-11-15 EC EC2010010607A patent/ECSP10010607A/en unknown
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