ECSP10010693A - Compuestos pirazólicos 436 - Google Patents

Compuestos pirazólicos 436

Info

Publication number
ECSP10010693A
ECSP10010693A EC2010010693A ECSP10010693A ECSP10010693A EC SP10010693 A ECSP10010693 A EC SP10010693A EC 2010010693 A EC2010010693 A EC 2010010693A EC SP10010693 A ECSP10010693 A EC SP10010693A EC SP10010693 A ECSP10010693 A EC SP10010693A
Authority
EC
Ecuador
Prior art keywords
compounds
pirazolic
therapy
processes
formula
Prior art date
Application number
EC2010010693A
Other languages
English (en)
Inventor
Maria-Elena Theoclitou
Andrew Peter Thomas
David Buttar
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40935715&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP10010693(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP10010693A publication Critical patent/ECSP10010693A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporcionan nuevos compuestos de fórmula (Ia) o (Ib): o sales farmacéuticamente aceptables de estos, procesos para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia.
EC2010010693A 2008-06-19 2010-12-17 Compuestos pirazólicos 436 ECSP10010693A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7388308P 2008-06-19 2008-06-19

Publications (1)

Publication Number Publication Date
ECSP10010693A true ECSP10010693A (es) 2011-01-31

Family

ID=40935715

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010693A ECSP10010693A (es) 2008-06-19 2010-12-17 Compuestos pirazólicos 436

Country Status (23)

Country Link
US (1) US20090318468A1 (es)
EP (1) EP2328872A1 (es)
JP (1) JP2011524888A (es)
KR (1) KR20110020904A (es)
CN (1) CN102123989A (es)
AR (1) AR072261A1 (es)
AU (1) AU2009261683A1 (es)
BR (1) BRPI0914233A2 (es)
CA (1) CA2728063A1 (es)
CL (1) CL2010001470A1 (es)
CO (1) CO6351726A2 (es)
CR (1) CR11857A (es)
DO (1) DOP2010000387A (es)
EA (1) EA201100030A1 (es)
EC (1) ECSP10010693A (es)
IL (1) IL210082A0 (es)
MX (1) MX2010014234A (es)
PE (1) PE20110062A1 (es)
SV (1) SV2010003767A (es)
TW (1) TW201002693A (es)
UY (1) UY31918A (es)
WO (1) WO2009153592A1 (es)
ZA (1) ZA201100471B (es)

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UA114501C2 (uk) 2012-02-28 2017-06-26 Астеллас Фарма Інк. Азотовмісна ароматична гетероциклічна сполука
LT3495367T (lt) 2012-06-13 2021-02-25 Incyte Holdings Corporation Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai
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US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
AR094812A1 (es) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd Derivado de piridina monocíclico como inhibidor del fgfr
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MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
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EP3424505A4 (en) * 2016-03-04 2019-10-16 Taiho Pharmaceutical Co., Ltd. PREPARATION AND COMPOSITION FOR THE TREATMENT OF MALIGNANT TUMORS
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
RU2771311C2 (ru) 2017-08-15 2022-04-29 Сиэсписи Чжунци Фармасьютикал Текнолоджи (Шишцзяжуан) Ко., Лтд. Ингибитор fgfr и его медицинское применение
EP4470621A3 (en) 2018-03-19 2025-05-07 Taiho Pharmaceutical Co., Ltd. Use of sodium alkyl sulfate
JPWO2019189241A1 (ja) 2018-03-28 2021-03-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 肝細胞癌治療剤
CN110317173B (zh) * 2018-03-30 2022-10-11 上海奕拓医药科技有限责任公司 用作fgfr不可逆抑制剂的酰胺基吡唑类化合物
ES3061844T3 (en) 2018-05-04 2026-04-07 Incyte Corp Salts of an fgfr inhibitor
MX2020011718A (es) 2018-05-04 2021-02-15 Incyte Corp Formas solidas de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr) y procesos para prepararlas.
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
EP3942045A1 (en) 2019-03-21 2022-01-26 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
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Also Published As

Publication number Publication date
WO2009153592A1 (en) 2009-12-23
CR11857A (es) 2011-02-25
EP2328872A1 (en) 2011-06-08
DOP2010000387A (es) 2012-09-30
CL2010001470A1 (es) 2011-05-06
CA2728063A1 (en) 2009-12-23
JP2011524888A (ja) 2011-09-08
KR20110020904A (ko) 2011-03-03
AR072261A1 (es) 2010-08-18
SV2010003767A (es) 2011-05-20
CO6351726A2 (es) 2011-12-20
BRPI0914233A2 (pt) 2015-11-03
CN102123989A (zh) 2011-07-13
US20090318468A1 (en) 2009-12-24
EA201100030A1 (ru) 2011-08-30
TW201002693A (en) 2010-01-16
UY31918A (es) 2010-01-29
IL210082A0 (en) 2011-02-28
PE20110062A1 (es) 2011-03-09
ZA201100471B (en) 2012-06-27
MX2010014234A (es) 2011-03-25
AU2009261683A1 (en) 2009-12-23

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