ECSP10010710A - Nuevas carboxamidas heterociclicas para su uso como inhibidores de trombina - Google Patents

Nuevas carboxamidas heterociclicas para su uso como inhibidores de trombina

Info

Publication number
ECSP10010710A
ECSP10010710A EC2010010710A ECSP10010710A ECSP10010710A EC SP10010710 A ECSP10010710 A EC SP10010710A EC 2010010710 A EC2010010710 A EC 2010010710A EC SP10010710 A ECSP10010710 A EC SP10010710A EC SP10010710 A ECSP10010710 A EC SP10010710A
Authority
EC
Ecuador
Prior art keywords
carboxamids
thrombin inhibitors
heterociclic
new
new heterociclic
Prior art date
Application number
EC2010010710A
Other languages
English (en)
Inventor
Ingemar Nilsson
Magnus Polla
Jonas Braanalt
Original Assignee
Astrazeneca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca filed Critical Astrazeneca
Publication of ECSP10010710A publication Critical patent/ECSP10010710A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Esta invención se relaciona con nuevos compuestos farmacéuticamente útiles de la fórmula (I), en particular compuestos que son inhibidores competitivos de las serina proteasas similares a la tripsina, especialmente la trombina, su uso como medicamentos, las composiciones farmacéuticas que los contienen y las rutas sintéticas para su producción.
EC2010010710A 2008-06-23 2010-12-23 Nuevas carboxamidas heterociclicas para su uso como inhibidores de trombina ECSP10010710A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7473608P 2008-06-23 2008-06-23
US10238108P 2008-10-03 2008-10-03

Publications (1)

Publication Number Publication Date
ECSP10010710A true ECSP10010710A (es) 2011-01-31

Family

ID=41431868

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010710A ECSP10010710A (es) 2008-06-23 2010-12-23 Nuevas carboxamidas heterociclicas para su uso como inhibidores de trombina

Country Status (20)

Country Link
US (2) US20110130432A1 (es)
EP (1) EP2321301A4 (es)
JP (1) JP2011525487A (es)
KR (1) KR20110025970A (es)
CN (1) CN102131802A (es)
AR (1) AR072278A1 (es)
AU (1) AU2009263076B2 (es)
BR (1) BRPI0914323A2 (es)
CA (1) CA2727925A1 (es)
CO (1) CO6321275A2 (es)
CR (1) CR11873A (es)
DO (1) DOP2010000402A (es)
EA (1) EA018502B1 (es)
EC (1) ECSP10010710A (es)
IL (1) IL210076A0 (es)
MX (1) MX2010014229A (es)
TW (1) TW201002689A (es)
UY (1) UY31923A (es)
WO (1) WO2009157860A1 (es)
ZA (1) ZA201100568B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8354444B2 (en) 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
RU2570896C2 (ru) * 2013-04-23 2015-12-20 Общество с ограниченной ответственностью "Химико-фармацевтические технологии" (ООО "ХимФармТех") (4-фтор-бензил)-этил-(2-тетразол-1-ил-фенил)-амин и способ его получения
CN104529923B (zh) * 2015-01-13 2016-06-01 佛山市赛维斯医药科技有限公司 二烯四氮唑硝基苯类化合物、其制备方法和用途
CN104610184A (zh) * 2015-01-13 2015-05-13 佛山市赛维斯医药科技有限公司 苯二烯四氮唑类化合物、其制备方法和用途
WO2019040109A1 (en) * 2017-08-21 2019-02-28 Celgene Corporation PROCESSES FOR THE PREPARATION OF (S) -TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE
US12440285B2 (en) * 2021-01-22 2025-10-14 Cilag Gmbh International Prediction of hemostasis issues based on biomarker monitoring
CN113636982A (zh) * 2021-04-28 2021-11-12 合肥工业大学 一种肉桂酸衍生物及其制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
JPH11503161A (ja) * 1995-04-04 1999-03-23 メルク エンド カンパニー インコーポレーテッド トロンビン阻害剤
AR013084A1 (es) * 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
DE69824433D1 (en) 1997-08-28 2004-07-15 Biovitrum Ab Proteintyrosinphosphatase inhibitoren
HUP0100082A3 (en) * 1998-01-26 2001-12-28 Abbott Gmbh & Co Kg Thrombin inhibitor, peptide derivatives, pharmaceutical compositions comprising thereof and their use
US6482921B1 (en) 1999-01-28 2002-11-19 Essential Therapeutics, Inc. Uridyl peptide antibiotic (UPA) derivatives, their synthesis and use
FR2793248B1 (fr) * 1999-05-03 2001-06-29 Adir Nouveaux derives de 2,3-methano-aminoacides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SE0001803D0 (sv) * 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6528503B2 (en) * 2000-12-18 2003-03-04 Merck & Co., Inc. Thrombin inhibitors
JP2004516286A (ja) * 2000-12-18 2004-06-03 メルク エンド カムパニー インコーポレーテッド ベンジルアミン誘導体およびそれのトロンビン阻害薬としての使用
US7144899B2 (en) * 2001-02-09 2006-12-05 Merck & Co., Inc. Thrombin inhibitors
UA78195C2 (uk) * 2001-08-30 2007-03-15 Astrazeneca Ab Похідні мигдалевої кислоти та їх застосування як інгібіторів тромбіну, фармацевтична композиція на їх основі
WO2004032834A2 (en) * 2002-10-04 2004-04-22 Merck & Co., Inc. Thrombin inhibitors
GB0327761D0 (en) 2003-11-29 2003-12-31 Astrazeneca Ab Compounds
PT2104497E (pt) 2006-12-06 2015-06-09 Sanofi Sa Derivados de ureia e sulfamida enquanto inibidores de tafia
TW200911787A (en) 2007-07-03 2009-03-16 Astrazeneca Ab New aza-bicyclohexane compounds useful as inhibitors of thrombin
KR101673886B1 (ko) 2008-06-06 2016-11-08 사노피 ＴＡＦＩａ의 억제제로서의 마크로사이클릭 우레아 및 술파미드 유도체

Also Published As

Publication number Publication date
US8119673B2 (en) 2012-02-21
BRPI0914323A2 (pt) 2017-03-28
CN102131802A (zh) 2011-07-20
EP2321301A4 (en) 2011-09-28
US20110130432A1 (en) 2011-06-02
JP2011525487A (ja) 2011-09-22
KR20110025970A (ko) 2011-03-14
AU2009263076A1 (en) 2009-12-30
AR072278A1 (es) 2010-08-18
UY31923A (es) 2010-01-29
EA018502B1 (ru) 2013-08-30
CA2727925A1 (en) 2009-12-30
EP2321301A1 (en) 2011-05-18
TW201002689A (en) 2010-01-16
AU2009263076B2 (en) 2012-07-26
ZA201100568B (en) 2012-06-27
CO6321275A2 (es) 2011-09-20
WO2009157860A1 (en) 2009-12-30
US20090318517A1 (en) 2009-12-24
CR11873A (es) 2011-02-28
IL210076A0 (en) 2011-02-28
DOP2010000402A (es) 2011-01-15
MX2010014229A (es) 2011-06-20
EA201001823A1 (ru) 2011-06-30

Similar Documents

Publication Publication Date Title
UY31203A1 (es) Nuevos compuestos de aza-biciclohexano útiles como inhibidores de trombina
CR11873A (es) Nuevas carboxamidas heterociclicas para su uso como inhibidores de trombina
CO6362015A2 (es) Derivados de acido 1-amino-2ciclobutiletilboronico
CU23840B1 (es) Nuevos derivados de sulfonamida como antagonistas de la bradiquinina
UY30748A1 (es) Compuesto0s novedosos
DOP2010000191A (es) Derivados bis-(sulfonilamino)
ECSP10010434A (es) Inhibidores de hsp90
SV2010003751A (es) Derivados de isoxazol y su uso como potenciadores de los receptores metabotropicos de glutamato
CR20110309A (es) Compuestos orgánicos
ECSP11011184A (es) Compuestos orgánicos
ECSP109856A (es) Derivados de oxadiazol y su uso como potenciadores de los receptores metabotrópicos de glutamato - 842
ECSP10010246A (es) Inhibidores de beta-lactamasa
UY31260A1 (es) Compuestos de pirazol, composiciones conteniendolos y aplicaciones.
SV2011003855A (es) Heteroarilos sustituidos
UY30444A1 (es) Derivados de pirimidina, procesos para su preparacinn, composiciones farmaccuticos y usos de los mismos.
ECSP077259A (es) Derivados de pirimidina
BR112012019042A8 (pt) compostos inibidores de serina protease tipo tripsina, seu uso, e seus processos de preparação
CL2011002911A1 (es) Compuestos derivados de benzamidas, inhibidores de serina proteasa; composición farmacéutica; uso del compuesto para tratar cáncer.
CU23944B1 (es) Amidas del ácido pirrolidin-1,2-dicarboxílico sustituidas como moduladores de calicreína 7
UY30856A1 (es) Nuevos derivados de 2,4 dianilinopirimidinas, su preparacion, como medicamentos, composiciones farmacéuticas y principalmente como inhibidores de ikk
ECSP14006696A (es) Agentes de reversión anticoagulante
CU20090064A7 (es) Nuevos derivados de benzamida como antagonistas de la bradiquinina
UY29325A1 (es) Nuevos derivados de 2 - amino-piridina
UY32635A (es) Derivados de bis-(sulfonilamino) en terapia 735
ECSP10010200A (es) Derivados de pirazol como inhibidores de 5-lo