ECSP109962A - Nuevos compuestos antimicrobianos, su síntesis y su uso para el tratamiento de infecciones en mamíferos - Google Patents
Nuevos compuestos antimicrobianos, su síntesis y su uso para el tratamiento de infecciones en mamíferosInfo
- Publication number
- ECSP109962A ECSP109962A EC2010009962A ECSP109962A ECSP109962A EC SP109962 A ECSP109962 A EC SP109962A EC 2010009962 A EC2010009962 A EC 2010009962A EC SP109962 A ECSP109962 A EC SP109962A EC SP109962 A ECSP109962 A EC SP109962A
- Authority
- EC
- Ecuador
- Prior art keywords
- halogenated
- chain
- members
- linear
- branched
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 241000124008 Mammalia Species 0.000 title abstract 2
- 230000000845 anti-microbial effect Effects 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 206010061822 Drug intolerance Diseases 0.000 abstract 1
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000002547 new drug Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 201000008827 tuberculosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a nuevos compuestos antimicrobianos, a su síntesis y a su uso para el tratamiento de infecciones en mamíferos. La presente invención está dirigida a la generación de nuevos compuestos con actividad contra mycobacterias como nuevos fármacos potenciales contra la tuberculosis para superar problemas concernientes a la resistencia y a la intolerancia a fármacos. Este objetivo ha sido resuelto proporcionando compuestos de la fórmula 1, en donde R1 y R2 son, independientemente uno del otro, NO2, NR7R8, NHOR9, COOR9, CN, CONR10R11, CHO, F, Cl, Br, SO2NR12R13, alcoxi inferior, OCF3, mono-, di o trifluorometilo; R3 y R4 son, independientemente uno del otro, H, un radical alifático saturado o insaturado, lineal o ramificado con 1-3 miembros en la cadena, F, Cl, Br, alcoxi inferior; R5 es H, un radical alifático saturado o insaturado, halogenado o no halogenado, lineal o ramificado, con 1 -7 miembros en la cadena; R6 es un radical; donde X es un radical alifático saturado o insaturado, halogenado o no halogenado, lineal o ramificado, con 1-5 miembros en la cadena, o R5 y R6 juntos representan radicales bivalentes donde n es 1-4; R7 - R13 son, independientemente unos de los otros, H o un radical alifático saturado o insaturado, halogenado o no halogenado, lineal o ramificado, con 1-5 miembros en la cadena, fenilo, bencilo o R7 y R8 juntos, R10 y R11 juntos, R12 y R13 juntos, representan un radical alifático bivalente, lineal o ramificado, con 1-7 miembros en la cadena; R14 y R15 son, independientemente uno del otro, H, un radical alifático lineal o ramificado con 1-5 miembros en la cadena, F, Cl, Br, NO2, NH2, CF3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07013899A EP2020406A1 (en) | 2007-07-16 | 2007-07-16 | New antimicrobial compounds, their synthesis and their use for treatment of mammalian infection |
| PCT/EP2008/005142 WO2009010163A1 (en) | 2007-07-16 | 2008-06-25 | New antimicrobial compounds, their synthesis and their use for treatment of mammalian infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP109962A true ECSP109962A (es) | 2010-03-31 |
Family
ID=38777913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2010009962A ECSP109962A (es) | 2007-07-16 | 2010-02-12 | Nuevos compuestos antimicrobianos, su síntesis y su uso para el tratamiento de infecciones en mamíferos |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8440842B2 (es) |
| EP (2) | EP2020406A1 (es) |
| JP (1) | JP5502731B2 (es) |
| KR (1) | KR101588064B1 (es) |
| CN (1) | CN101809009B (es) |
| AP (1) | AP2010005131A0 (es) |
| AT (1) | ATE482939T1 (es) |
| AU (1) | AU2008278056B2 (es) |
| BR (1) | BRPI0813828A2 (es) |
| CA (1) | CA2693088C (es) |
| CO (1) | CO6321160A2 (es) |
| CR (1) | CR11240A (es) |
| DE (1) | DE602008002843D1 (es) |
| EA (1) | EA017806B1 (es) |
| EC (1) | ECSP109962A (es) |
| MA (1) | MA31607B1 (es) |
| MX (1) | MX2010000672A (es) |
| NI (1) | NI201000012A (es) |
| NZ (1) | NZ582620A (es) |
| TN (1) | TN2010000023A1 (es) |
| UA (1) | UA99300C2 (es) |
| WO (1) | WO2009010163A1 (es) |
| ZA (1) | ZA201000491B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2380886A1 (en) | 2010-04-23 | 2011-10-26 | Vadim A. Makarov | Process for the preparation of 2-aminosubstituted 1,3-benzothiazine-4-ones |
| US8796264B2 (en) * | 2010-11-19 | 2014-08-05 | Ecole Polytechnique Federale De Lausanne (Epfl) | 2-piperazin-1-yl-4H-1,3-benzothiazin-4-one derivatives and their use for the treatment of mammalian infections |
| EP2468746A1 (en) | 2010-12-23 | 2012-06-27 | The University of Queensland | Benzothiazinone compounds and their use as anti-tuberculosis agents |
| CN102276598B (zh) * | 2011-05-27 | 2014-11-05 | 四川大学 | 苯并噻嗪硫酮衍生物及其制备方法和用途 |
| EP2570413A1 (en) | 2011-09-15 | 2013-03-20 | The University Of Queensland | Benzothiazinone derivatives as anti-tuberculosis agents |
| CN103508980B (zh) * | 2012-06-14 | 2016-07-06 | 四川大学 | 苯并噻嗪-4-酮衍生物及其制备方法和用途 |
| US9708339B2 (en) * | 2014-06-09 | 2017-07-18 | University Of Notre Dame Du Lac | 1,3-benzothiazinone, sulfoxide, and sulfone compounds with electrophilic substituent |
| DE102014012546A1 (de) * | 2014-09-26 | 2016-03-31 | Martin-Luther-Universität Halle-Wittenberg | Antimykobakteriell wirksame Substanzen, Verfahren zu ihrer Herstellung und deren Verwendung |
| EP3072889A1 (en) | 2015-03-23 | 2016-09-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | 2-Homopiperazine-1-yl-4H-1,3-benzothiazine-4-one derivatives and process for the preparation of 2-(homo)piperazine 1,3-benzothiazine-4-one hydrochlorides |
| WO2017019181A1 (en) | 2015-07-27 | 2017-02-02 | 6th Wave Innovations Corp. | Molecularly imprinted polymer beads for extraction of metals and uses thereof |
| CN105294597B (zh) * | 2015-11-03 | 2017-11-24 | 华东师范大学 | 苯并噻嗪类衍生物及其合成方法和应用 |
| CN110312725B (zh) | 2016-09-22 | 2022-03-11 | 莱比尼兹自然研究和感染生物学研究所协会汉斯诺尔研究所(Hki) | 新型抗菌化合物，其在哺乳动物感染治疗中的应用及新的代谢机制 |
| BR112019009018A2 (pt) | 2016-11-03 | 2019-09-10 | 6th Wave Innovations Corp. | esferas de polímero de impressão molecular para extração de lítio, mercúrio e escândio |
| CN108929329B (zh) * | 2017-05-24 | 2020-12-11 | 中国医学科学院药物研究所 | 2-氮杂环-5-三氟甲基-8-硝基苯并(硫代)吡喃-4-酮类化合物 |
| CN108947952B (zh) * | 2017-05-24 | 2021-09-21 | 中国医学科学院药物研究所 | 2-取代氨基-5-三氟甲基-8-硝基苯并（硫代）吡喃-4-酮类化合物及其制备方法和用途 |
| CN111303075A (zh) * | 2020-04-08 | 2020-06-19 | 苏州大学 | 苯并噻嗪酮衍生物及其制备方法与作为抗结核药物的应用 |
| CN111269197A (zh) * | 2020-04-08 | 2020-06-12 | 苏州大学 | 苯并噻嗪酮化合物及其制备方法与作为抗结核药物的应用 |
| WO2022204902A1 (zh) * | 2021-03-29 | 2022-10-06 | 苏州大学 | 6- 位三氟甲基取代的苯并噻嗪酮衍生物及其制备方法与应用 |
| WO2023065182A1 (zh) * | 2021-10-20 | 2023-04-27 | 苏州大学 | 一种基于炔基连接臂的苯并噻嗪酮衍生物及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3522247A (en) * | 1967-11-07 | 1970-07-28 | Pfizer & Co C | 2-amino-6,7-disubstituted-4h-1,3-benzothiazine-4-ones as bronchodilators |
| US5690598A (en) * | 1996-09-27 | 1997-11-25 | Liang; Yung Jen | Wrist exerciser |
| US7659267B2 (en) * | 2002-12-05 | 2010-02-09 | Takeda Pharmaceutical Company Limited | 1,3-Benzothiazinone derivatives, process for producing the same use thereof |
| EP1732907A1 (en) * | 2004-03-26 | 2006-12-20 | Arpida A/S | Peptide deformylase inhibitors |
| AU2006343832B2 (en) * | 2006-05-24 | 2011-07-21 | Leibniz Institute For Natural Product Research And Infection Biology E.V. Hans-Knoll-Institut (Hki) | New benzothiazinone derivatives and their use as antibacterial agents |
-
2007
- 2007-07-16 EP EP07013899A patent/EP2020406A1/en not_active Withdrawn
-
2008
- 2008-06-25 AP AP2010005131A patent/AP2010005131A0/en unknown
- 2008-06-25 EA EA201070145A patent/EA017806B1/ru not_active IP Right Cessation
- 2008-06-25 WO PCT/EP2008/005142 patent/WO2009010163A1/en not_active Ceased
- 2008-06-25 EP EP08773648A patent/EP2176248B1/en active Active
- 2008-06-25 DE DE602008002843T patent/DE602008002843D1/de active Active
- 2008-06-25 UA UAA201001591A patent/UA99300C2/ru unknown
- 2008-06-25 KR KR1020107003264A patent/KR101588064B1/ko active Active
- 2008-06-25 NZ NZ582620A patent/NZ582620A/en not_active IP Right Cessation
- 2008-06-25 AT AT08773648T patent/ATE482939T1/de not_active IP Right Cessation
- 2008-06-25 JP JP2010516390A patent/JP5502731B2/ja active Active
- 2008-06-25 CN CN2008800248917A patent/CN101809009B/zh active Active
- 2008-06-25 BR BRPI0813828-1A2A patent/BRPI0813828A2/pt not_active IP Right Cessation
- 2008-06-25 CA CA2693088A patent/CA2693088C/en active Active
- 2008-06-25 MX MX2010000672A patent/MX2010000672A/es active IP Right Grant
- 2008-06-25 US US12/669,748 patent/US8440842B2/en active Active
- 2008-06-25 AU AU2008278056A patent/AU2008278056B2/en not_active Ceased
-
2010
- 2010-01-13 TN TNP2010000023A patent/TN2010000023A1/fr unknown
- 2010-01-15 NI NI201000012A patent/NI201000012A/es unknown
- 2010-01-21 ZA ZA201000491A patent/ZA201000491B/xx unknown
- 2010-01-27 CR CR11240A patent/CR11240A/es not_active Application Discontinuation
- 2010-02-11 MA MA32614A patent/MA31607B1/fr unknown
- 2010-02-12 EC EC2010009962A patent/ECSP109962A/es unknown
- 2010-02-16 CO CO10017435A patent/CO6321160A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2020406A1 (en) | 2009-02-04 |
| KR20100043071A (ko) | 2010-04-27 |
| CA2693088C (en) | 2016-08-30 |
| CN101809009A (zh) | 2010-08-18 |
| AU2008278056A1 (en) | 2009-01-22 |
| MA31607B1 (fr) | 2010-08-02 |
| AU2008278056B2 (en) | 2013-09-26 |
| JP5502731B2 (ja) | 2014-05-28 |
| EA201070145A1 (ru) | 2010-06-30 |
| NZ582620A (en) | 2012-03-30 |
| CR11240A (es) | 2010-05-19 |
| EA017806B1 (ru) | 2013-03-29 |
| AP2010005131A0 (en) | 2010-02-28 |
| CA2693088A1 (en) | 2009-01-22 |
| EP2176248A1 (en) | 2010-04-21 |
| ZA201000491B (en) | 2010-10-27 |
| EP2176248B1 (en) | 2010-09-29 |
| DE602008002843D1 (de) | 2010-11-11 |
| CO6321160A2 (es) | 2011-09-20 |
| TN2010000023A1 (en) | 2011-09-26 |
| UA99300C2 (ru) | 2012-08-10 |
| ATE482939T1 (de) | 2010-10-15 |
| CN101809009B (zh) | 2013-04-24 |
| US8440842B2 (en) | 2013-05-14 |
| NI201000012A (es) | 2010-05-14 |
| BRPI0813828A2 (pt) | 2015-01-06 |
| WO2009010163A1 (en) | 2009-01-22 |
| MX2010000672A (es) | 2010-05-17 |
| KR101588064B1 (ko) | 2016-01-22 |
| US20100286130A1 (en) | 2010-11-11 |
| JP2010533661A (ja) | 2010-10-28 |
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