ECSP11010801A - Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de crf1 - Google Patents

Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de crf1

Info

Publication number
ECSP11010801A
ECSP11010801A EC2011010801A ECSP11010801A ECSP11010801A EC SP11010801 A ECSP11010801 A EC SP11010801A EC 2011010801 A EC2011010801 A EC 2011010801A EC SP11010801 A ECSP11010801 A EC SP11010801A EC SP11010801 A ECSP11010801 A EC SP11010801A
Authority
EC
Ecuador
Prior art keywords
crf1
derivatives
antigonist
pirazolo
oxazol
Prior art date
Application number
EC2011010801A
Other languages
English (en)
Inventor
Ian Bruce
Nicholas James Devereux
Andrew James Culshaw
Francois Gessier
Jeffrey Mickenna
James Neff
Helen Elizabeth Oakman
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP11010801A publication Critical patent/ECSP11010801A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • AIDS & HIV (AREA)

Abstract

Se describen derivados de pirazolo-[5.1-b]-oxazol de la estructura I útiles como antagonistas del receptor del factor de liberación de corticotropina (CRF1).
EC2011010801A 2008-08-06 2011-02-02 Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de crf1 ECSP11010801A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08161930 2008-08-06
US20509609P 2009-01-14 2009-01-14
EP09150553 2009-01-14

Publications (1)

Publication Number Publication Date
ECSP11010801A true ECSP11010801A (es) 2011-03-31

Family

ID=41653505

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011010801A ECSP11010801A (es) 2008-08-06 2011-02-02 Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de crf1

Country Status (18)

Country Link
US (1) US7994203B2 (es)
EP (1) EP2328902A1 (es)
JP (1) JP2011529943A (es)
KR (1) KR20110051226A (es)
CN (1) CN102171220A (es)
AR (1) AR073262A1 (es)
AU (1) AU2009279137A1 (es)
BR (1) BRPI0917565A2 (es)
CA (1) CA2733176A1 (es)
CO (1) CO6351723A2 (es)
EA (1) EA201100303A1 (es)
EC (1) ECSP11010801A (es)
IL (1) IL211030A0 (es)
MA (1) MA32537B1 (es)
MX (1) MX2011001392A (es)
TW (1) TW201011039A (es)
UY (1) UY32029A (es)
WO (1) WO2010015628A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY152687A (en) 2008-04-15 2014-10-31 Eisai R&D Man Co Ltd 3-phenylpyrazolo[5,1-b]thiazole compound
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
AR078521A1 (es) 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
JPWO2011043387A1 (ja) 2009-10-08 2013-03-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロオキサゾール化合物
CN102762572A (zh) * 2010-02-01 2012-10-31 诺瓦提斯公司 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
UY34094A (es) 2011-05-27 2013-01-03 Novartis Ag Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013164790A1 (en) 2012-05-03 2013-11-07 Novartis Ag L-malate salt of 2, 7 - diaza - spiro [4.5 ] dec- 7 - yle derivatives and crystalline forms thereof as ghrelin receptor agonists
KR20210064407A (ko) 2014-01-21 2021-06-02 뉴로크린 바이오사이언시즈 인코퍼레이티드 선천성 부신 과형성 치료를 위한 ｃｒｆ1 수용체 길항제
KR20200035035A (ko) 2017-07-31 2020-04-01 노파르티스 아게 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도
PL3984523T3 (pl) 2018-12-07 2026-02-02 Neurocrine Biosciences, Inc. Antagonista receptora crf1, jego formulacje farmaceutyczne i postacie stałe do leczenia wrodzonego przerostu nadnerczy
US12383536B2 (en) 2019-09-27 2025-08-12 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods of use
ES3039926T3 (en) 2019-12-04 2025-10-27 Neurocrine Biosciences Inc Crf receptor antagonists and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031517A1 (en) * 1995-04-04 1996-10-10 E.I. Du Pont De Nemours And Company Herbicidal heteroaryl-substituted anilides
US6888004B2 (en) * 2001-01-26 2005-05-03 Bristol-Myers Squibb Company Imidazolyl derivatives as corticotropin releasing factor inhibitors

Also Published As

Publication number Publication date
IL211030A0 (en) 2011-04-28
UY32029A (es) 2010-03-26
MX2011001392A (es) 2011-03-25
JP2011529943A (ja) 2011-12-15
AU2009279137A1 (en) 2010-02-11
AR073262A1 (es) 2010-10-28
CN102171220A (zh) 2011-08-31
AU2009279137A8 (en) 2011-03-03
EP2328902A1 (en) 2011-06-08
BRPI0917565A2 (pt) 2015-11-17
CO6351723A2 (es) 2011-12-20
US7994203B2 (en) 2011-08-09
TW201011039A (en) 2010-03-16
CA2733176A1 (en) 2010-02-11
MA32537B1 (fr) 2011-08-01
KR20110051226A (ko) 2011-05-17
EA201100303A1 (ru) 2011-10-31
US20100035874A1 (en) 2010-02-11
WO2010015628A1 (en) 2010-02-11

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