ECSP11010884A - METHOD OF IDENTIFICATION OF RISK FACTORS OF THE DISEASE - Google Patents
METHOD OF IDENTIFICATION OF RISK FACTORS OF THE DISEASEInfo
- Publication number
- ECSP11010884A ECSP11010884A ECSP11010884A ECSP11010884A EC SP11010884 A ECSP11010884 A EC SP11010884A EC SP11010884 A ECSP11010884 A EC SP11010884A EC SP11010884 A ECSP11010884 A EC SP11010884A
- Authority
- EC
- Ecuador
- Prior art keywords
- disease
- identification
- genetic variant
- alzheimer
- interest
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000002068 genetic effect Effects 0.000 abstract 4
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 101150101855 tomm-40 gene Proteins 0.000 abstract 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Aquí se proporciona un método para la identificación de una variante genética que está asociada con el desarrollo de un padecimiento de interés (por ejemplo, la enfermedad de Alzheimer), y las variantes genéticas identificadas de esta manera. También se proporcionan métodos de tratamiento con un ingrediente activo (por ejemplo, con un agente activo particular y/o en una etapa más temprana), al momento de detectar una variante genética aquí descrita. En algunas modalidades, la variante genética es un polimorfismo de eliminación/inserción (DIP) del gen TOMM40. También se proporcionan los equipos para determinar si un sujeto se encuentra en un riesgo aumentado de desarrollar la enfermedad de Alzheimer de presentación tardía. Además se proporcionan equipos para determinar si un sujeto actúa en respuesta al tratamiento para un padecimiento de interés con un agente activo.Here a method is provided for the identification of a genetic variant that is associated with the development of a disease of interest (for example, Alzheimer's disease), and the genetic variants identified in this way. Methods of treatment with an active ingredient (for example, with a particular active agent and / or at an earlier stage) are also provided, at the time of detecting a genetic variant described herein. In some embodiments, the genetic variant is a deletion / insertion polymorphism (DIP) of the TOMM40 gene. Equipment is also provided to determine if a subject is at an increased risk of developing late-presenting Alzheimer's disease. In addition, equipment is provided to determine if a subject acts in response to treatment for a condition of interest with an active agent.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8820308P | 2008-08-12 | 2008-08-12 | |
| US18667309P | 2009-06-12 | 2009-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP11010884A true ECSP11010884A (en) | 2011-12-30 |
Family
ID=47827565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP11010884 ECSP11010884A (en) | 2008-08-12 | 2011-03-11 | METHOD OF IDENTIFICATION OF RISK FACTORS OF THE DISEASE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP11010884A (en) |
-
2011
- 2011-03-11 EC ECSP11010884 patent/ECSP11010884A/en unknown
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