ECSP11011100A - Síntesis de morfina-6-glucurónido o de uno de sus derivados - Google Patents
Síntesis de morfina-6-glucurónido o de uno de sus derivadosInfo
- Publication number
- ECSP11011100A ECSP11011100A EC2011011100A ECSP11011100A ECSP11011100A EC SP11011100 A ECSP11011100 A EC SP11011100A EC 2011011100 A EC2011011100 A EC 2011011100A EC SP11011100 A ECSP11011100 A EC SP11011100A EC SP11011100 A ECSP11011100 A EC SP11011100A
- Authority
- EC
- Ecuador
- Prior art keywords
- group
- derivatives
- responds
- reacting
- following formula
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 abstract 1
- GNJCUHZOSOYIEC-GAROZEBRSA-N Morphine-6-glucuronide Chemical compound O([C@H]1C=C[C@H]2[C@H]3CC=4C5=C(C(=CC=4)O)O[C@@H]1[C@]52CCN3C)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O GNJCUHZOSOYIEC-GAROZEBRSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical class O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 abstract 1
- 239000003849 aromatic solvent Substances 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 isobutyryl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparación de morfina-6-glucurónido o de uno de sus derivados, que comprende las etapas que consisten: (ii) en hacer reaccionar un compuesto que responde a la fórmula (I) siguiente : en la que: R1 representa un grupo carbonilo, COR5CO o S02R6S02 con un derivado de ácido glucurónico que responde a la fórmula (II) siguiente: en la que: PG representa un grupo acetilo, isobutirilo, benzoílo o pivaloílo, X representa un grupo trihalógenoacetamidato, y R4 representa un grupo alquil(C1-C4)carboxilato; en presencia de un disolvente aromático y de trifluorometanosulfonilo de trimetilsilano (ii) en hacer reaccionar el producto obtenido en la etapa (i) con un agente fuertemente básico, después (iii) en recuperar el producto obtenido en la etapa (ii).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0806948A FR2939436B1 (fr) | 2008-12-10 | 2008-12-10 | Synthese de morphine-6-glucuronide ou de l'un de ses derives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP11011100A true ECSP11011100A (es) | 2011-07-29 |
Family
ID=40996840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2011011100A ECSP11011100A (es) | 2008-12-10 | 2011-06-03 | Síntesis de morfina-6-glucurónido o de uno de sus derivados |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8258298B2 (es) |
| EP (1) | EP2376496B1 (es) |
| JP (1) | JP5619768B2 (es) |
| KR (1) | KR20110091534A (es) |
| CN (1) | CN102307876B (es) |
| AR (1) | AR074513A1 (es) |
| AU (1) | AU2009326906B2 (es) |
| BR (1) | BRPI0923238A2 (es) |
| CA (1) | CA2746428A1 (es) |
| CL (1) | CL2011001398A1 (es) |
| CO (1) | CO6390060A2 (es) |
| CR (1) | CR20110307A (es) |
| EA (1) | EA201170790A1 (es) |
| EC (1) | ECSP11011100A (es) |
| ES (1) | ES2470666T3 (es) |
| FR (1) | FR2939436B1 (es) |
| HN (1) | HN2011001597A (es) |
| IL (1) | IL213379A0 (es) |
| MA (1) | MA32950B1 (es) |
| MX (1) | MX337925B (es) |
| MY (1) | MY152276A (es) |
| NI (1) | NI201100116A (es) |
| NZ (1) | NZ593342A (es) |
| PE (1) | PE20110836A1 (es) |
| SG (1) | SG172069A1 (es) |
| TN (1) | TN2011000243A1 (es) |
| TW (1) | TW201033218A (es) |
| UA (1) | UA103643C2 (es) |
| WO (1) | WO2010067007A2 (es) |
| ZA (1) | ZA201104657B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10807995B2 (en) | 2018-07-13 | 2020-10-20 | Alkermes Pharma Ireland Limited | Thienothiophene compounds for long-acting injectable compositions and related methods |
| US10799496B2 (en) | 2018-07-13 | 2020-10-13 | Alkermes Pharma Ireland Limited | Naphthylenyl compounds for long-acting injectable compositions and related methods |
| WO2020094634A1 (en) | 2018-11-05 | 2020-05-14 | Alkermes Pharma Ireland Limited | Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3766188A (en) * | 1971-06-28 | 1973-10-16 | Yamanouchi Pharma Co Ltd | Carbonyldioxymorphinan derivatives |
| GB9116909D0 (en) * | 1991-08-06 | 1991-09-18 | Salford Ultrafine Chem & Res | Morphine derivatives |
| GB2282758A (en) | 1993-08-23 | 1995-04-19 | Euro Celtique Sa | Oral morphine-6-glucuronide compositions |
| JP2001518912A (ja) | 1997-04-14 | 2001-10-16 | ソルフォード、ウルトラファイン、ケミカルズ、アンド、リサーチ、リミテッド | モルヒネ誘導体 |
| DE69903291T2 (de) * | 1998-06-06 | 2003-06-26 | Cenes Ltd., Cambridge | Synthese von morphin-6-glucuronid |
| GB9914382D0 (en) * | 1999-06-21 | 1999-08-18 | Ufc Limited | New process for the manufacture of morphine-6-glucuronide and its analogues and also to a manufacture of new intermediaries |
| DE60239801D1 (de) * | 2001-06-05 | 2011-06-01 | Control Delivery Systems Watertown | Analgetika mit verzögerter wirkstoffabgabe |
| US6740641B2 (en) * | 2001-07-27 | 2004-05-25 | Euro-Celtique, S.A. | Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain |
| JP2005526790A (ja) * | 2002-03-19 | 2005-09-08 | ミシェル ホリック | アポモルフィンおよび類縁体の配糖体およびオルトエステル配糖体誘導体、ならびにそれらの使用方法 |
| FR2864082B1 (fr) * | 2003-12-22 | 2006-03-10 | Synt Em | Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur |
-
2008
- 2008-12-10 FR FR0806948A patent/FR2939436B1/fr not_active Expired - Fee Related
-
2009
- 2009-12-08 JP JP2011540161A patent/JP5619768B2/ja not_active Expired - Fee Related
- 2009-12-08 BR BRPI0923238A patent/BRPI0923238A2/pt not_active IP Right Cessation
- 2009-12-08 AU AU2009326906A patent/AU2009326906B2/en not_active Ceased
- 2009-12-08 CA CA2746428A patent/CA2746428A1/fr not_active Abandoned
- 2009-12-08 ES ES09803824.3T patent/ES2470666T3/es active Active
- 2009-12-08 NZ NZ593342A patent/NZ593342A/xx not_active IP Right Cessation
- 2009-12-08 CN CN200980156211.1A patent/CN102307876B/zh not_active Expired - Fee Related
- 2009-12-08 MX MX2011006264A patent/MX337925B/es active IP Right Grant
- 2009-12-08 SG SG2011042322A patent/SG172069A1/en unknown
- 2009-12-08 UA UAA201108590A patent/UA103643C2/ru unknown
- 2009-12-08 PE PE2011001187A patent/PE20110836A1/es not_active Application Discontinuation
- 2009-12-08 MA MA33997A patent/MA32950B1/fr unknown
- 2009-12-08 WO PCT/FR2009/052445 patent/WO2010067007A2/fr not_active Ceased
- 2009-12-08 EA EA201170790A patent/EA201170790A1/ru unknown
- 2009-12-08 EP EP09803824.3A patent/EP2376496B1/fr active Active
- 2009-12-08 KR KR1020117013141A patent/KR20110091534A/ko not_active Abandoned
- 2009-12-08 MY MYPI20112601 patent/MY152276A/en unknown
- 2009-12-09 TW TW098142093A patent/TW201033218A/zh unknown
- 2009-12-09 AR ARP090104751A patent/AR074513A1/es unknown
-
2011
- 2011-05-17 TN TN2011000243A patent/TN2011000243A1/fr unknown
- 2011-06-03 EC EC2011011100A patent/ECSP11011100A/es unknown
- 2011-06-05 IL IL213379A patent/IL213379A0/en unknown
- 2011-06-06 CR CR20110307A patent/CR20110307A/es unknown
- 2011-06-08 US US13/155,646 patent/US8258298B2/en not_active Expired - Fee Related
- 2011-06-08 NI NI201100116A patent/NI201100116A/es unknown
- 2011-06-09 CL CL2011001398A patent/CL2011001398A1/es unknown
- 2011-06-09 HN HN2011001597A patent/HN2011001597A/es unknown
- 2011-06-10 CO CO11072135A patent/CO6390060A2/es active IP Right Grant
- 2011-06-23 ZA ZA2011/04657A patent/ZA201104657B/en unknown
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