ECSP11011172A - Derivados de tieno [3,2-c]piridina como inhibidores de quinasas para el uso en el tratamiento del cáncer. - Google Patents

Derivados de tieno [3,2-c]piridina como inhibidores de quinasas para el uso en el tratamiento del cáncer.

Info

Publication number
ECSP11011172A
ECSP11011172A EC2011011172A ECSP11011172A ECSP11011172A EC SP11011172 A ECSP11011172 A EC SP11011172A EC 2011011172 A EC2011011172 A EC 2011011172A EC SP11011172 A ECSP11011172 A EC SP11011172A EC SP11011172 A ECSP11011172 A EC SP11011172A
Authority
EC
Ecuador
Prior art keywords
tieno
piridine
derivatives
kinase inhibitors
cancer treatment
Prior art date
Application number
EC2011011172A
Other languages
English (en)
Inventor
L Michael Curtin
Michael R Michaelides
Robin R Frey
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ECSP11011172A publication Critical patent/ECSP11011172A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos que inhiben proteína quinasas, tales como aurora-quinasas y las familias de quinasas VEGFR y PDGFR, con un perfil de seguridad mejorado debido a una baja inhibición de CYP3A4, composiciones que contienen los compuestos y métodos de tratamiento de enfermedades usando los compuestos.
EC2011011172A 2008-12-05 2011-07-01 Derivados de tieno [3,2-c]piridina como inhibidores de quinasas para el uso en el tratamiento del cáncer. ECSP11011172A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12028108P 2008-12-05 2008-12-05
US22376009P 2009-07-08 2009-07-08

Publications (1)

Publication Number Publication Date
ECSP11011172A true ECSP11011172A (es) 2011-08-31

Family

ID=41559043

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011011172A ECSP11011172A (es) 2008-12-05 2011-07-01 Derivados de tieno [3,2-c]piridina como inhibidores de quinasas para el uso en el tratamiento del cáncer.

Country Status (25)

Country Link
US (2) US20100144783A1 (es)
EP (1) EP2373662B1 (es)
JP (1) JP5588458B2 (es)
KR (1) KR101639642B1 (es)
CN (1) CN102239171B (es)
AR (1) AR074481A1 (es)
AU (1) AU2009322270B2 (es)
BR (1) BRPI0921392A2 (es)
CA (1) CA2743592A1 (es)
CL (1) CL2011001312A1 (es)
CO (1) CO6382131A2 (es)
DO (1) DOP2011000153A (es)
EC (1) ECSP11011172A (es)
ES (1) ES2524966T3 (es)
IL (1) IL212716A (es)
MX (1) MX2011005943A (es)
MY (1) MY179042A (es)
NZ (1) NZ592714A (es)
PA (1) PA8852401A1 (es)
PE (1) PE20110830A1 (es)
RU (2) RU2480472C2 (es)
TW (2) TWI441827B (es)
UA (1) UA103351C2 (es)
UY (1) UY32291A (es)
WO (1) WO2010065825A2 (es)

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US12624049B2 (en) 2020-05-11 2026-05-12 University Health Network Salt and crystal forms of 4-amino-5-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-z-yl)thieno[2.3-b]pyridin-6(7H)-one

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Also Published As

Publication number Publication date
PE20110830A1 (es) 2011-12-14
IL212716A (en) 2013-10-31
MY179042A (en) 2020-10-26
US8722890B2 (en) 2014-05-13
IL212716A0 (en) 2011-07-31
BRPI0921392A2 (pt) 2016-04-26
AR074481A1 (es) 2011-01-19
TW201431862A (zh) 2014-08-16
PA8852401A1 (es) 2010-07-27
MX2011005943A (es) 2011-06-27
DOP2011000153A (es) 2011-06-30
EP2373662B1 (en) 2014-09-24
KR101639642B1 (ko) 2016-07-14
US20100144783A1 (en) 2010-06-10
CO6382131A2 (es) 2012-02-15
CA2743592A1 (en) 2010-06-10
UY32291A (es) 2010-07-30
CN102239171B (zh) 2014-06-11
WO2010065825A3 (en) 2010-08-26
AU2009322270A1 (en) 2011-07-14
RU2480472C2 (ru) 2013-04-27
UA103351C2 (uk) 2013-10-10
CL2011001312A1 (es) 2011-10-07
TW201026706A (en) 2010-07-16
EP2373662A2 (en) 2011-10-12
US20120309783A1 (en) 2012-12-06
HK1159628A1 (en) 2012-08-03
JP5588458B2 (ja) 2014-09-10
CN102239171A (zh) 2011-11-09
RU2012156958A (ru) 2014-06-27
TWI441827B (zh) 2014-06-21
WO2010065825A2 (en) 2010-06-10
TWI500621B (zh) 2015-09-21
ES2524966T3 (es) 2014-12-16
AU2009322270B2 (en) 2014-12-18
JP2012511016A (ja) 2012-05-17
RU2011127451A (ru) 2013-01-10
KR20110091577A (ko) 2011-08-11
NZ592714A (en) 2013-03-28

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