ECSP12011569A - Derivados de pirazoles, su preparación y su aplicación terapéutica - Google Patents

Derivados de pirazoles, su preparación y su aplicación terapéutica

Info

Publication number
ECSP12011569A
ECSP12011569A EC2012011569A ECSP12011569A ECSP12011569A EC SP12011569 A ECSP12011569 A EC SP12011569A EC 2012011569 A EC2012011569 A EC 2012011569A EC SP12011569 A ECSP12011569 A EC SP12011569A EC SP12011569 A ECSP12011569 A EC SP12011569A
Authority
EC
Ecuador
Prior art keywords
preparation
derivatives
pirazoles
therapeutic application
application
Prior art date
Application number
EC2012011569A
Other languages
English (en)
Inventor
Michel Tabart
Pascal Desmazeau
Pierre Yves Abecassis
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of ECSP12011569A publication Critical patent/ECSP12011569A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere los derivados de pirazoles de la fórmula general (I) en la que: en donde X representa cloro o flúor. Procedimiento de preparación y aplicación en terapéutica
EC2012011569A 2009-07-03 2012-01-03 Derivados de pirazoles, su preparación y su aplicación terapéutica ECSP12011569A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0903270A FR2947546B1 (fr) 2009-07-03 2009-07-03 Derives de pyrazoles, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ECSP12011569A true ECSP12011569A (es) 2012-02-29

Family

ID=41695643

Family Applications (2)

Application Number Title Priority Date Filing Date
EC2012011569A ECSP12011569A (es) 2009-07-03 2012-01-03 Derivados de pirazoles, su preparación y su aplicación terapéutica
ECSP12011659 ECSP12011659A (es) 2009-07-03 2012-01-03 Formulaciones orales sólidas y formas cristalinas de un inhibidor de la proteína de apoptosis

Family Applications After (1)

Application Number Title Priority Date Filing Date
ECSP12011659 ECSP12011659A (es) 2009-07-03 2012-01-03 Formulaciones orales sólidas y formas cristalinas de un inhibidor de la proteína de apoptosis

Country Status (30)

Country Link
US (1) US8367715B2 (es)
EP (1) EP2448924B1 (es)
JP (1) JP5680640B2 (es)
KR (1) KR20120037967A (es)
CN (1) CN102471280B (es)
AR (1) AR077371A1 (es)
AU (1) AU2010267824A1 (es)
BR (1) BR112012000104A2 (es)
CA (1) CA2767096A1 (es)
CL (1) CL2012000013A1 (es)
CO (1) CO6480992A2 (es)
CR (1) CR20110701A (es)
DO (1) DOP2012000001A (es)
EA (1) EA020364B1 (es)
EC (2) ECSP12011569A (es)
FR (1) FR2947546B1 (es)
IL (1) IL217300A0 (es)
MA (1) MA33500B1 (es)
MX (1) MX2012000267A (es)
MY (1) MY155829A (es)
NI (1) NI201200001A (es)
NZ (1) NZ597578A (es)
PE (1) PE20120917A1 (es)
SG (1) SG177463A1 (es)
TN (1) TN2011000658A1 (es)
TW (1) TWI471312B (es)
UA (1) UA106500C2 (es)
UY (1) UY32757A (es)
WO (1) WO2011001122A2 (es)
ZA (1) ZA201200027B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2908409B1 (fr) * 2006-11-10 2009-01-09 Sanofi Aventis Sa Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation
EP2802324A4 (en) * 2012-01-09 2015-07-15 X Rx Inc BENZHYDROL-PYRAZOLE DERIVATIVES WITH KINASE-INHIBITORY EFFECT AND USES THEREOF
AR094812A1 (es) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd Derivado de piridina monocíclico como inhibidor del fgfr
WO2016027781A1 (ja) 2014-08-18 2016-02-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 単環ピリジン誘導体の塩およびその結晶
CN114984013A (zh) 2015-03-25 2022-09-02 国立癌症研究中心 胆管癌治疗剂
AU2016374441B2 (en) 2015-12-17 2021-10-21 Eisai R&D Management Co., Ltd. Therapeutic agent for breast cancer
CN107619388A (zh) * 2016-07-13 2018-01-23 南京天印健华医药科技有限公司 作为fgfr抑制剂的杂环化合物
CN107840842A (zh) 2016-09-19 2018-03-27 北京天诚医药科技有限公司 炔代杂环化合物、其制备方法及其在医药学上的应用
BR112020017922A2 (pt) 2018-03-28 2020-12-22 Eisai R&D Management Co., Ltd. Agente terapêutico para carcinoma hepatocelular

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331541B1 (en) * 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
GB0317127D0 (en) * 2003-07-22 2003-08-27 Astex Technology Ltd Pharmaceutical compounds
WO2006077425A1 (en) * 2005-01-21 2006-07-27 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors and further antitumor agents
BRPI0619146A2 (pt) * 2005-12-02 2011-09-13 Bayer Pharmaceuticals Corp derivados de 4-amino-pirroltriazina substituìda úteis no tratamento de disordens e doenças hiperproliferativas associadas com angiogênesis
WO2007075377A2 (en) * 2005-12-15 2007-07-05 Cytokinetics, Inc. Certain chemical entities, compositions and methods
US20070208000A1 (en) * 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
FR2908409B1 (fr) * 2006-11-10 2009-01-09 Sanofi Aventis Sa Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation
KR20090092317A (ko) * 2006-12-11 2009-08-31 아이알엠 엘엘씨 키나제 억제제로서의 화합물 및 조성물

Also Published As

Publication number Publication date
SG177463A1 (en) 2012-02-28
DOP2012000001A (es) 2012-01-31
WO2011001122A3 (fr) 2011-02-24
NZ597578A (en) 2013-11-29
CN102471280B (zh) 2014-08-06
CA2767096A1 (fr) 2011-01-06
HK1169387A1 (en) 2013-01-25
ZA201200027B (en) 2013-03-27
EA020364B1 (ru) 2014-10-30
MA33500B1 (fr) 2012-08-01
US8367715B2 (en) 2013-02-05
MY155829A (en) 2015-12-15
CO6480992A2 (es) 2012-07-16
WO2011001122A2 (fr) 2011-01-06
UA106500C2 (uk) 2014-09-10
FR2947546A1 (fr) 2011-01-07
KR20120037967A (ko) 2012-04-20
JP2012531466A (ja) 2012-12-10
TWI471312B (zh) 2015-02-01
ECSP12011659A (es) 2012-03-30
BR112012000104A2 (pt) 2016-03-15
AR077371A1 (es) 2011-08-24
MX2012000267A (es) 2012-04-30
IL217300A0 (en) 2012-02-29
AU2010267824A1 (en) 2012-02-16
UY32757A (es) 2011-01-31
TW201107298A (en) 2011-03-01
JP5680640B2 (ja) 2015-03-04
FR2947546B1 (fr) 2011-07-01
CL2012000013A1 (es) 2012-09-14
EP2448924B1 (fr) 2013-09-04
CN102471280A (zh) 2012-05-23
EP2448924A2 (fr) 2012-05-09
US20120270918A1 (en) 2012-10-25
EA201270128A1 (ru) 2012-07-30
PE20120917A1 (es) 2012-08-17
CR20110701A (es) 2012-03-06
NI201200001A (es) 2012-03-30
TN2011000658A1 (fr) 2013-05-24

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