ECSP12011702A - THERAPEUTIC PROTEINS OF UNION TO DLL4 - Google Patents
THERAPEUTIC PROTEINS OF UNION TO DLL4Info
- Publication number
- ECSP12011702A ECSP12011702A ECSP12011702A ECSP12011702A EC SP12011702 A ECSP12011702 A EC SP12011702A EC SP12011702 A ECSP12011702 A EC SP12011702A EC SP12011702 A ECSP12011702 A EC SP12011702A
- Authority
- EC
- Ecuador
- Prior art keywords
- dll4
- angiogenesis
- binding proteins
- proteins
- dll4 binding
- Prior art date
Links
- 102100033553 Delta-like protein 4 Human genes 0.000 title abstract 8
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 title abstract 8
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 abstract 3
- 108091008324 binding proteins Proteins 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000033115 angiogenesis Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010029113 Neovascularisation Diseases 0.000 abstract 1
- 230000001594 aberrant effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000005747 tumor angiogenesis Effects 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se describen proteínas de unión a DLL4 mejoradas, se incluyen anticuerpos, anticuerpos con CDR injertadas, anticuerpos humanos, y fragmentos de unión a DLL4 de los mismos, proteínas que se unen a DLL4 con alta afinidad, y proteínas de unión a DLL4 que neutralizan la actividad de DLL4. Las proteínas de unión a DLL4 son útiles para tratar o prevenir cáncer y tumores, especialmente para el tratamiento o la prevención de la angiogénesis tumoral, y/u otras enfermedades dependientes de angiogénesis tales como la neovascularización ocular, o enfermedades independientes de la angiogénesis caracterizadas por expresión o actividad aberrante de DLL4 tal como trastornos autoinmune que incluyen la esclerosis múltiple.Improved DLL4 binding proteins are described, including antibodies, grafted CDR antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind to DLL4 with high affinity, and DLL4 binding proteins that neutralize the DLL4 activity. DLL4 binding proteins are useful for treating or preventing cancer and tumors, especially for the treatment or prevention of tumor angiogenesis, and / or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant expression or activity of DLL4 such as autoimmune disorders that include multiple sclerosis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23815209P | 2009-08-29 | 2009-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP12011702A true ECSP12011702A (en) | 2012-04-30 |
Family
ID=52281168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP12011702 ECSP12011702A (en) | 2009-08-29 | 2012-02-29 | THERAPEUTIC PROTEINS OF UNION TO DLL4 |
Country Status (2)
| Country | Link |
|---|---|
| EC (1) | ECSP12011702A (en) |
| UA (1) | UA105397C2 (en) |
-
2010
- 2010-08-27 UA UAA201203804A patent/UA105397C2/en unknown
-
2012
- 2012-02-29 EC ECSP12011702 patent/ECSP12011702A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UA105397C2 (en) | 2014-05-12 |
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