ECSP12011803A - Polipéptidos inmunomoduladores derivados de la il-2 y su uso terapéutico en cáncer y en infecciones crónicas - Google Patents

Polipéptidos inmunomoduladores derivados de la il-2 y su uso terapéutico en cáncer y en infecciones crónicas

Info

Publication number
ECSP12011803A
ECSP12011803A ECSP12011803A ECSP12011803A EC SP12011803 A ECSP12011803 A EC SP12011803A EC SP12011803 A ECSP12011803 A EC SP12011803A EC SP12011803 A ECSP12011803 A EC SP12011803A
Authority
EC
Ecuador
Prior art keywords
present
polypeptides
relates
cancer
sequence
Prior art date
Application number
Other languages
English (en)
Inventor
Monzón Kalet León
Portilla Tania Carmenate
Martínez Karina García
Dávila Agustín Bienvenido Lage
Rodriguez Saumel Pérez
Roche Diamile González
Perera Gabriel Márquez
Original Assignee
Ct De Inmunologia Molecular Cim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43646474&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12011803(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ct De Inmunologia Molecular Cim filed Critical Ct De Inmunologia Molecular Cim
Publication of ECSP12011803A publication Critical patent/ECSP12011803A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se relaciona en general con polipéptidos cuya secuencia primaria tiene una alta homología con la secuencia de la Interleucina 2 humana (IL-2) con algunas mutaciones puntuales en la secuencia de la IL-2 nativa. Los polipéptidos de la presenten invención tienen un efecto inmunomodulador sobre el sistema inmune, que es selectivo/ preferencial sobre células T reguladoras. La presente invención también se relaciona con polipéptidos específicos cuya secuencia de aminoácidos es divulgada en la presente invención. En otro aspecto la presente invención se relaciona con las composiciones farmacéuticas que comprenden como principio activo los polipéptidos divulgados. Por último, la presente invención se relaciona con el uso terapéutico de los polipéptidos y composiciones farmacéuticas divulgados dado su efecto modulador del sistema inmune sobre patologías como cáncer y enfermedades infecciosas crónicas.
ECSP12011803 2009-11-27 2012-04-17 Polipéptidos inmunomoduladores derivados de la il-2 y su uso terapéutico en cáncer y en infecciones crónicas ECSP12011803A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20090203A CU23734A1 (es) 2009-11-27 2009-11-27 Polipéptidos inmunomoduladores derivados de la il-2 con actividad antagonista de esta citocina útiles en la terapia del cáncer y enfermedades infecciosas crónicas

Publications (1)

Publication Number Publication Date
ECSP12011803A true ECSP12011803A (es) 2012-07-31

Family

ID=43646474

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12011803 ECSP12011803A (es) 2009-11-27 2012-04-17 Polipéptidos inmunomoduladores derivados de la il-2 y su uso terapéutico en cáncer y en infecciones crónicas

Country Status (24)

Country Link
US (1) US8759486B2 (es)
EP (1) EP2505206B1 (es)
JP (1) JP5680661B2 (es)
KR (1) KR101484590B1 (es)
CN (1) CN102665754B (es)
AR (1) AR079197A1 (es)
AU (1) AU2010324254B2 (es)
BR (1) BR112012012025B8 (es)
CA (1) CA2781173C (es)
CL (1) CL2012001030A1 (es)
CO (1) CO6501124A2 (es)
CU (1) CU23734A1 (es)
EA (1) EA021867B1 (es)
EC (1) ECSP12011803A (es)
ES (1) ES2643465T3 (es)
MX (1) MX2012006077A (es)
MY (1) MY162324A (es)
NZ (1) NZ599792A (es)
PE (1) PE20121636A1 (es)
PH (1) PH12012500812A1 (es)
SG (1) SG181089A1 (es)
TN (1) TN2012000182A1 (es)
WO (1) WO2011063770A2 (es)
ZA (1) ZA201203762B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012088446A1 (en) 2010-12-22 2012-06-28 Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
CN105722860A (zh) 2013-09-24 2016-06-29 梅迪塞纳医疗股份有限公司 白介素-2融合蛋白及其应用
JP2017509652A (ja) 2014-03-17 2017-04-06 ブンデスリパブリク ドイツランド レツバートレテン ダーチ ダス ロバート コシュ−インスティテュト バートレテン ダーチ セイネン プラジデンテン 細胞性の細胞傷害性免疫応答を誘導または延長する方法における使用のための医薬
JP6592505B2 (ja) * 2014-04-24 2019-10-16 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー インターロイキン−２のスーパーアンタゴニスト、パーシャルアゴニスト及びアンタゴニスト
WO2017096262A1 (en) 2015-12-04 2017-06-08 Jomoco, Corp. Compositions and methods to mitigate or prevent an immune response to an immunogenic therapeutic molecule in non-human primates
US10858428B2 (en) 2016-09-28 2020-12-08 Xoma (Us) Llc Antibodies that bind interleukin-2 and uses thereof
CU24483B1 (es) 2016-11-15 2020-04-02 Ct Inmunologia Molecular Método para incrementar los niveles de secreción de la interleucina-2
CN110913954A (zh) 2017-03-03 2020-03-24 黑曜石疗法公司 免疫疗法的组合物和方法
BR112019018915A2 (pt) 2017-03-15 2020-04-14 Pandion Therapeutics Inc imunotolerância direcionada
AU2018273914A1 (en) 2017-05-24 2019-11-14 Pandion Operations, Inc. Targeted immunotolerance
AU2018287317B2 (en) 2017-06-19 2024-06-20 Medicenna Therapeutics Inc. Uses and methods for IL-2 superagonists, agonists, and fusions thereof
IL321812A (en) 2017-08-03 2025-08-01 Synthorx Inc Cytokine complexes for the treatment of autoimmune diseases
KR102777151B1 (ko) 2017-11-21 2025-03-05 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 인터루킨-2의 부분 효능제
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US12565525B2 (en) * 2018-03-28 2026-03-03 Ascendis Pharma Oncology Division A/S IL-2 conjugates
PE20210313A1 (es) 2018-03-28 2021-02-12 Bristol Myers Squibb Co Proteinas de fusion interleucina-2/receptor alfa de interleucina-2 y metodos de uso
EP3802587A4 (en) * 2018-06-07 2022-03-23 Prottech Inc. PHARMACEUTICAL COMPOSITION WITH A FUSION PROTEIN AND THEIR USE
US20220403001A1 (en) 2018-06-12 2022-12-22 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
MA54952A (fr) 2019-02-06 2022-05-11 Synthorx Inc Conjugués d'il-2 et méthodes d'utilisation de ceux-ci
AU2020279240A1 (en) 2019-05-20 2021-12-23 Pandion Operations, Inc. MAdCAM targeted immunotolerance
WO2021050554A1 (en) 2019-09-10 2021-03-18 Synthorx, Inc. Il-2 conjugates and methods of use to treat autoimmune diseases
CA3162320A1 (en) 2019-12-23 2021-07-01 Alexander V. SHIROKOV Methods of preparing n6-((2-azidoethoxy)carbonyl)lysine
CN115362168A (zh) 2020-01-14 2022-11-18 辛德凯因股份有限公司 偏向化il2突变蛋白方法和组合物
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
CA3178074A1 (en) 2020-06-03 2021-12-09 Nina Gunnarsson Il-2 sequences and uses thereof
KR20230060514A (ko) * 2020-09-01 2023-05-04 다케다 야쿠힌 고교 가부시키가이샤 인터루킨-2 뮤테인 및 이의 용도
CN116323653A (zh) 2020-09-04 2023-06-23 山东先声生物制药有限公司 Il-2突变体及其应用
KR20230112632A (ko) 2020-10-23 2023-07-27 애셔 바이오테라퓨틱스, 인크. 면역 세포 기능을 조절하기 위한 cd8 항원 결합 분자와의 융합
US20240325495A1 (en) 2020-10-29 2024-10-03 Bristol-Myers Squibb Company Fusion proteins for the treatment of disease
BR112023022485A2 (pt) 2021-04-30 2024-01-09 Centre Hospitalier Univ Vaudois Chuv Expansão de linfócitos em um único recipiente
EP4376870A4 (en) * 2021-07-28 2025-07-23 Anwita Biosciences Inc INTERLEUKIN-2 MUTEINS, FUSION PROTEINS, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC APPLICATIONS
US20250082777A1 (en) 2022-01-10 2025-03-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
AU2023372974A1 (en) 2022-11-02 2025-06-12 Centre Hospitalier Universitaire Vaudois (Chuv) Expansion of lymphocytes
WO2024261339A1 (en) 2023-06-23 2024-12-26 Tigen Pharma Sa Lymphocyte-stimulatory matrix (lsm) and uses thereof for expansion of lymphocyte populations

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853332A (en) 1982-10-19 1989-08-01 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US5116943A (en) 1985-01-18 1992-05-26 Cetus Corporation Oxidation-resistant muteins of Il-2 and other protein
JP3024311B2 (ja) 1991-10-03 2000-03-21 味の素株式会社 Ｉｌ−２受容体重鎖に結合するポリペプチド
US5229109A (en) 1992-04-14 1993-07-20 Board Of Regents, The University Of Texas System Low toxicity interleukin-2 analogues for use in immunotherapy
US5635597A (en) 1994-05-27 1997-06-03 Affymax Technologies, N.V. Peptides that bind IL-2 receptors
US6955807B1 (en) 1998-05-15 2005-10-18 Bayer Pharmaceuticals Corporation IL-2 selective agonists and antagonists
US6168785B1 (en) 1998-07-16 2001-01-02 Institut Pasteur Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents
EP1105421A2 (en) 1998-08-21 2001-06-13 Yeda Research & Development Company, Ltd. Anti-inflammatory peptides derived from il-2 and analogues thereof
EP1454138B1 (en) 2001-12-04 2012-01-18 Merck Patent GmbH Immunocytokines with modulated selectivity
WO2005007121A2 (en) 2003-07-18 2005-01-27 Massachusetts Institute Of Technology Mutant interleukin-2(il-2) polypeptides
JP2009542592A (ja) * 2006-07-06 2009-12-03 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｉｌ−２媒介性免疫応答の有効性を高める組成物および方法
WO2009061853A2 (en) * 2007-11-05 2009-05-14 Massachusetts Institute Of Technology Mutant interleukin-2 (il-2) polypeptides
DE102008023820A1 (de) * 2008-05-08 2009-11-12 Aicuris Gmbh & Co. Kg Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen

Also Published As

Publication number Publication date
WO2011063770A2 (es) 2011-06-03
BR112012012025A2 (pt) 2016-05-17
CL2012001030A1 (es) 2012-07-20
EA021867B1 (ru) 2015-09-30
US8759486B2 (en) 2014-06-24
KR20120106728A (ko) 2012-09-26
AR079197A1 (es) 2012-01-04
NZ599792A (en) 2014-01-31
CN102665754B (zh) 2014-03-12
EP2505206B1 (en) 2017-09-27
EA201290395A1 (ru) 2012-10-30
WO2011063770A3 (es) 2011-09-09
CA2781173A1 (en) 2011-06-03
KR101484590B1 (ko) 2015-01-22
US20120315245A1 (en) 2012-12-13
MY162324A (en) 2017-05-31
PE20121636A1 (es) 2012-12-03
CO6501124A2 (es) 2012-08-15
BR112012012025B8 (pt) 2021-05-25
HK1169961A1 (en) 2013-02-15
JP5680661B2 (ja) 2015-03-04
SG181089A1 (en) 2012-07-30
ZA201203762B (en) 2013-01-30
ES2643465T3 (es) 2017-11-23
CU23734A1 (es) 2011-11-15
CA2781173C (en) 2015-10-13
JP2013512200A (ja) 2013-04-11
MX2012006077A (es) 2012-09-07
CN102665754A (zh) 2012-09-12
EP2505206A2 (en) 2012-10-03
PH12012500812A1 (en) 2016-01-27
AU2010324254A1 (en) 2012-05-31
TN2012000182A1 (en) 2013-12-12
AU2010324254B2 (en) 2014-01-09
BR112012012025B1 (pt) 2021-05-11

Similar Documents

Publication Publication Date Title
CU23734A1 (es) Polipéptidos inmunomoduladores derivados de la il-2 con actividad antagonista de esta citocina útiles en la terapia del cáncer y enfermedades infecciosas crónicas
CU23923B1 (es) Polipéptidos derivados de la il-2 con actividad agonista
BR112016012538A2 (pt) peptídeos citotóxicos e conjugados dos mesmos
BR112017025108A2 (pt) compostos seletivos de pyy e usos dos mesmos
CY1119616T1 (el) Συζευγματα ανθρωπινου αντισωματος-φαρμακου κατα του ιστικου παραγοντα
MX2021005358A (es) Metodos y composiciones que comprenden polipeptidos recombinantes purificados.
CR20160117A (es) Anticuerpos contra el inhibidor del activador de plasminógeno tipo 1 (pai-1) y usos de los mismos
MX386142B (es) COMPOSICIONES INMUNOGÉNICAS PARA EL CORONAVIRUS DEL SÍNDROME RESPIRATORIO DE ORIENTE MEDIO (MERS-CoV) Y SUS USOS.
EA201490610A1 (ru) Соединения и способы усиления врожденных иммунных ответов
CO7010783A2 (es) Proteína naglu humana recombinante y usos de la misma
EA201590667A1 (ru) Ациламинопиримидиновые производные для лечения вирусных инфекций и других заболеваний
CL2012001836A1 (es) Compuestos de pirazol, antagonista de crth2; composicion farmacéutica; uso en el tratamiento de trastornos inflamatorios, infecciosos, inmunoreguladores, enfermedades respiratorias, gastrointestinales o dolencias, entre otros.
CR20140475A (es) Agentes terapéuticos para administración subcutánea optimizados
BR112015023793A2 (pt) composições e métodos de terapias para indução de tolerância imune a substituição do fator vii em indivíduos com hemofilia a
BR112015013125A2 (pt) tratamento de lesões orais usando composições de matrix placentário extracelular
BR112015015250A2 (pt) derivados de pirrolidina, composições farmacêuticas e usos dos mesmos
BR112014026407A2 (pt) formulação de vacina líquida
MX392532B (es) Glicoproteinas recombinantes y sus usos.
CO7400865A2 (es) Polipeptidos derivados del tgfbeta y sus usos
PY1939780A (es) Composiciones farmacéuticas para el tratamiento de la deficiencia de esfingomielinasa ácida
BR112018016715A2 (pt) ?formulações de oritavancina?
RU2013141485A (ru) Биологически активные пептиды
EA201992746A3 (ru) Рекомбинантные гликопротеиды и их применения
AR098154A1 (es) Glicoproteínas recombinantes y sus usos
TR201201022A2 (tr) Akciğer hastalıkları, karaciğer hastalıkları ve çeşitli enfeksiyonların semptomatik ve/veya terapötik tedavisinde kullanılan farmasötik bileşimler.