ECSP12011945A - Espiroindolinona-pirrolidinas - Google Patents

Espiroindolinona-pirrolidinas

Info

Publication number
ECSP12011945A
ECSP12011945A ECSP12011945A ECSP12011945A EC SP12011945 A ECSP12011945 A EC SP12011945A EC SP12011945 A ECSP12011945 A EC SP12011945A EC SP12011945 A ECSP12011945 A EC SP12011945A
Authority
EC
Ecuador
Prior art keywords
pirrolidinas
espiroindolinona
compounds
enantiomers
esters
Prior art date
Application number
Other languages
English (en)
Inventor
David Joseph Bartkovitz
Xin Jie Chu
Qingjie Ding
Nan Jiang
Zhuming Zhang
Jing Zhang
Bradford James Graves
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ECSP12011945A publication Critical patent/ECSP12011945A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Se proporcionan compuestos de la fórmulaen la que X, Y y de R1 a R8 tienen los significados aquí definidos, junto con los enantiómeros, las sales farmacéuticamente aceptables y los ésteres de los mismos. Estos compuestos son útiles como agentes anticancerosos.
ECSP12011945 2009-12-02 2012-06-01 Espiroindolinona-pirrolidinas ECSP12011945A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26579209P 2009-12-02 2009-12-02
US38805410P 2010-09-30 2010-09-30

Publications (1)

Publication Number Publication Date
ECSP12011945A true ECSP12011945A (es) 2012-07-31

Family

ID=43608656

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12011945 ECSP12011945A (es) 2009-12-02 2012-06-01 Espiroindolinona-pirrolidinas

Country Status (26)

Country Link
US (1) US8088815B2 (es)
EP (1) EP2507243B1 (es)
JP (1) JP5647262B2 (es)
KR (1) KR101418191B1 (es)
CN (1) CN102741257B (es)
AR (1) AR079226A1 (es)
AU (1) AU2010326855B2 (es)
BR (1) BR112012012872A2 (es)
CA (1) CA2781823A1 (es)
CL (1) CL2012001405A1 (es)
CO (1) CO6541606A2 (es)
CR (1) CR20120259A (es)
EC (1) ECSP12011945A (es)
ES (1) ES2543468T3 (es)
IL (1) IL220010A (es)
MA (1) MA33976B1 (es)
MX (1) MX2012006260A (es)
MY (1) MY160596A (es)
NZ (1) NZ600024A (es)
PE (1) PE20121334A1 (es)
PH (1) PH12012501029A1 (es)
RU (1) RU2571100C2 (es)
SG (1) SG181465A1 (es)
TW (1) TW201129571A (es)
WO (1) WO2011067185A1 (es)
ZA (1) ZA201204036B (es)

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CN103342672B (zh) * 2013-07-02 2015-12-23 扬州大学 取代吡咯烷-2-酮的新合成方法
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ES2959097T3 (es) * 2014-08-18 2024-02-20 Hudson Biopharma Inc Espiropirrolidinas como inhibidores de MDM2
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CN107106642B (zh) 2014-09-24 2021-02-26 艾瑞朗医疗公司 拟肽大环化合物及其制剂
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Also Published As

Publication number Publication date
CO6541606A2 (es) 2012-10-16
ZA201204036B (en) 2013-02-27
EP2507243A1 (en) 2012-10-10
WO2011067185A1 (en) 2011-06-09
CN102741257A (zh) 2012-10-17
EP2507243B1 (en) 2015-06-10
KR20120101481A (ko) 2012-09-13
NZ600024A (en) 2014-08-29
US20110130398A1 (en) 2011-06-02
AU2010326855B2 (en) 2015-10-29
JP5647262B2 (ja) 2014-12-24
AR079226A1 (es) 2012-01-04
BR112012012872A2 (pt) 2017-10-10
IL220010A0 (en) 2012-07-31
CA2781823A1 (en) 2011-06-09
TW201129571A (en) 2011-09-01
MX2012006260A (es) 2012-06-19
AU2010326855A1 (en) 2012-06-21
ES2543468T3 (es) 2015-08-19
CL2012001405A1 (es) 2012-09-28
SG181465A1 (en) 2012-07-30
PE20121334A1 (es) 2012-10-12
RU2012125763A (ru) 2014-01-10
PH12012501029A1 (en) 2013-01-14
US8088815B2 (en) 2012-01-03
IL220010A (en) 2014-03-31
CR20120259A (es) 2012-07-12
RU2571100C2 (ru) 2015-12-20
KR101418191B1 (ko) 2014-07-09
MA33976B1 (fr) 2013-02-01
MY160596A (en) 2017-03-15
CN102741257B (zh) 2015-03-04
JP2013512869A (ja) 2013-04-18
HK1173720A1 (en) 2013-05-24

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