ECSP12012356A - DERIVATIVES OF QUINOLIZIDINE AND INDOLIZIDINE - Google Patents
DERIVATIVES OF QUINOLIZIDINE AND INDOLIZIDINEInfo
- Publication number
- ECSP12012356A ECSP12012356A ECSP12012356A ECSP12012356A EC SP12012356 A ECSP12012356 A EC SP12012356A EC SP12012356 A ECSP12012356 A EC SP12012356A EC SP12012356 A ECSP12012356 A EC SP12012356A
- Authority
- EC
- Ecuador
- Prior art keywords
- glyt
- compounds
- lower alkyl
- glycine
- inhibitors
- Prior art date
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención, se refiere a compuestos de la fórmula general I-A ó I-B I-A y I-B en donde, X, es un enlace o un grupo -CH2, R1, R2 y R3 son, de una forma independiente, las unas con respecto a las otras, hidrógeno, alcoxi inferior, alquilo inferior sustituido por halógeno, ó S-alquilo inferior; o a sales de adición de ácidos, farmacéuticamente aceptables, a una mezcla racémica, o sus correspondientes enantiómeros y / o isómeros ópticos de éste.Se ha encontrado el hecho de que, los compuestos de las fórmulas generales I-A y I-B, son buenos inhibidores del transportador de glicina 1 (GlyT-1), y que éstos tienen una buena selectividad a los inhibidores del transportador de glicina 2 (GlyT-2), apropiados en el tratamiento de los trastornos neurológicos y neuropsiquiátricos.The present invention relates to compounds of the general formula IA or IB IA and IB wherein, X, is a bond or a group -CH2, R1, R2 and R3 are, independently, the ones with respect to the others, hydrogen, lower alkoxy, lower alkyl substituted by halogen, or S-lower alkyl; or to pharmaceutically acceptable acid addition salts, to a racemic mixture, or their corresponding enantiomers and / or optical isomers thereof. It has been found that the compounds of the general formulas IA and IB are good transporter inhibitors of glycine 1 (GlyT-1), and that these have a good selectivity to glycine transporter 2 inhibitors (GlyT-2), appropriate in the treatment of neurological and neuropsychiatric disorders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP12012356 ECSP12012356A (en) | 2012-12-21 | 2012-12-21 | DERIVATIVES OF QUINOLIZIDINE AND INDOLIZIDINE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP12012356 ECSP12012356A (en) | 2012-12-21 | 2012-12-21 | DERIVATIVES OF QUINOLIZIDINE AND INDOLIZIDINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP12012356A true ECSP12012356A (en) | 2013-01-31 |
Family
ID=52634061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP12012356 ECSP12012356A (en) | 2012-12-21 | 2012-12-21 | DERIVATIVES OF QUINOLIZIDINE AND INDOLIZIDINE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP12012356A (en) |
-
2012
- 2012-12-21 EC ECSP12012356 patent/ECSP12012356A/en unknown
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