ECSP13013060A - Composiciones de nucleasa terapéuticas y métodos - Google Patents

Composiciones de nucleasa terapéuticas y métodos

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Publication number
ECSP13013060A
ECSP13013060A ECSP13013060A ECSP13013060A EC SP13013060 A ECSP13013060 A EC SP13013060A EC SP13013060 A ECSP13013060 A EC SP13013060A EC SP13013060 A ECSP13013060 A EC SP13013060A
Authority
EC
Ecuador
Prior art keywords
methods
therapeutic nuclease
nuclease compositions
compositions
therapeutic
Prior art date
Application number
Other languages
English (en)
Inventor
Jeffrey A Ledbetter
Martha Hay-Den-Ledbetter
Keith Elkon
Xizhang Sun
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of ECSP13013060A publication Critical patent/ECSP13013060A/es

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)

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  • Veterinary Medicine (AREA)
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Abstract

Moléculas de nucleasa híbridas y métodos para tratar en un mamífero una enfermedad o trastorno relacionado con el sistema inmunológico, y una composición farmacéutica para tratar en un mamífero una enfermedad relacionada con el sistema inmunológico.
ECSP13013060 2011-04-29 2013-11-28 Composiciones de nucleasa terapéuticas y métodos ECSP13013060A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161480961P 2011-04-29 2011-04-29
US201261617241P 2012-03-29 2012-03-29

Publications (1)

Publication Number Publication Date
ECSP13013060A true ECSP13013060A (es) 2015-03-31

Family

ID=47073103

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13013060 ECSP13013060A (es) 2011-04-29 2013-11-28 Composiciones de nucleasa terapéuticas y métodos

Country Status (28)

Country Link
US (6) US10202588B2 (es)
EP (2) EP3449933A1 (es)
JP (7) JP6063450B2 (es)
KR (6) KR20250037576A (es)
CN (2) CN107964539B (es)
AU (5) AU2012249360B2 (es)
BR (1) BR112013027547B1 (es)
CA (1) CA2834626A1 (es)
CL (1) CL2013003123A1 (es)
CO (1) CO6811815A2 (es)
CR (1) CR20130598A (es)
DK (1) DK2704737T3 (es)
DO (1) DOP2013000250A (es)
EA (1) EA201391585A1 (es)
EC (1) ECSP13013060A (es)
ES (1) ES2666303T3 (es)
HR (1) HRP20180564T1 (es)
HU (1) HUE038759T2 (es)
IL (5) IL313299A (es)
LT (1) LT2704737T (es)
MX (3) MX389061B (es)
NZ (1) NZ616989A (es)
PE (1) PE20141172A1 (es)
PH (1) PH12013502441B1 (es)
PL (1) PL2704737T3 (es)
SG (2) SG194680A1 (es)
SI (1) SI2704737T1 (es)
WO (1) WO2012149440A2 (es)

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US10988746B2 (en) * 2018-10-08 2021-04-27 Neutrolis, Inc. Manufacturing and engineering of DNASE enzymes for therapy
AU2020204992A1 (en) * 2019-01-04 2021-07-15 Resolve Therapeutics, Llc Treatment of sjogren's disease with nuclease fusion proteins
JP2020136505A (ja) 2019-02-20 2020-08-31 株式会社Ｊｏｌｅｄ 半導体装置および表示装置
BR112022013173A2 (pt) * 2020-01-11 2022-09-13 Univ Yale Composições e métodos para tratar, melhorar e/ou prevenir doenças ou transtornos causados por ou associados com a deficiência de dnase1 e/ou dnase1l3
AU2021288567A1 (en) * 2020-06-08 2023-02-09 Yale University Compositions and methods for treating and/or preventing coagulopathy and/or sepsis in patients suffering from bacterial and/or viral infections
CN112088903A (zh) * 2020-09-28 2020-12-18 武汉愔紫生物科技有限公司 一种大分子蛋白在抗菌抗病毒消毒剂中的应用
CA3207134A1 (en) 2021-02-19 2022-08-25 Jeffrey A. Ledbetter Dnase fusion polypeptides and related compositions and methods
CN115595315B (zh) * 2021-06-28 2024-08-16 四川大学华西医院 核糖核酸酶i在抑制疼痛的药物中的新用途
WO2026037276A1 (zh) * 2024-08-12 2026-02-19 上海交通大学医学院 一种减少线粒体dna泄露的方法

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