ECSP14024753A - Métodos y composiciones para modular la actividad notch - Google Patents

Métodos y composiciones para modular la actividad notch

Info

Publication number
ECSP14024753A
ECSP14024753A ECIEPI201424753A ECPI201424753A ECSP14024753A EC SP14024753 A ECSP14024753 A EC SP14024753A EC IEPI201424753 A ECIEPI201424753 A EC IEPI201424753A EC PI201424753 A ECPI201424753 A EC PI201424753A EC SP14024753 A ECSP14024753 A EC SP14024753A
Authority
EC
Ecuador
Prior art keywords
polypeptides
compositions
methods
modulate
notch activity
Prior art date
Application number
ECIEPI201424753A
Other languages
English (en)
Inventor
Spyridon Artavanis-Tsakonas
Robert Fleming
Original Assignee
Artavanis Tsakonas Spyridon
Fleming Robert J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Artavanis Tsakonas Spyridon, Fleming Robert J filed Critical Artavanis Tsakonas Spyridon
Publication of ECSP14024753A publication Critical patent/ECSP14024753A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En la presente se proporcionan los polipéptidos y derivados de estos que contienen secuencias de una proteína Serrate y que inhiben la función de la vía de Notch. También se proporcionan en la presente los ácidos nucleicos que codifican los polipéptidos, vectores y células para producir los polipéptidos, y las composiciones farmacéuticas y kits relacionados. Además se proporcionan los anticuerpos que se unen a la región de inhibición de Notch de una proteína Serrate. También se proporcionan métodos terapéuticos.
ECIEPI201424753A 2012-03-29 2014-10-28 Métodos y composiciones para modular la actividad notch ECSP14024753A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2012/031213 WO2013147793A1 (en) 2012-03-29 2012-03-29 Methods and compositions for modulating notch activity

Publications (1)

Publication Number Publication Date
ECSP14024753A true ECSP14024753A (es) 2015-09-30

Family

ID=49260857

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201424753A ECSP14024753A (es) 2012-03-29 2014-10-28 Métodos y composiciones para modular la actividad notch

Country Status (10)

Country Link
US (1) US20150291681A1 (es)
KR (1) KR20150014439A (es)
AU (1) AU2012375337A1 (es)
BR (1) BR112014024230A8 (es)
CA (1) CA2868747A1 (es)
CL (1) CL2014002596A1 (es)
EC (1) ECSP14024753A (es)
MX (1) MX2014011608A (es)
PH (1) PH12014502182A1 (es)
WO (1) WO2013147793A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201408554QA (en) 2012-06-22 2015-02-27 Cytomx Therapeutics Inc Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof
CN111269311B (zh) * 2019-09-30 2023-10-13 复旦大学 一种增强型合成Notch受体及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0861261T3 (da) * 1995-06-28 2009-12-14 Imp Cancer Res Tech Nukleotid- og proteinsekvenser af hvirveldyrs-Delta-gener og fremgangsmåder baseret derpå
WO2004082710A1 (en) * 2003-03-21 2004-09-30 Lorantis Limited Treatment of allergic diseases using a modulator of the notch signaling pathway

Also Published As

Publication number Publication date
KR20150014439A (ko) 2015-02-06
CA2868747A1 (en) 2013-10-03
AU2012375337A1 (en) 2014-10-16
PH12014502182A1 (en) 2014-12-10
WO2013147793A1 (en) 2013-10-03
US20150291681A1 (en) 2015-10-15
BR112014024230A8 (pt) 2017-07-25
CL2014002596A1 (es) 2015-07-10
BR112014024230A2 (es) 2017-06-20
MX2014011608A (es) 2015-05-11

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