ECSP14028230A - Proceso para la preparacion de treprostinil y derivados del mismo - Google Patents
Proceso para la preparacion de treprostinil y derivados del mismoInfo
- Publication number
- ECSP14028230A ECSP14028230A ECIEPI201428230A ECPI201428230A ECSP14028230A EC SP14028230 A ECSP14028230 A EC SP14028230A EC IEPI201428230 A ECIEPI201428230 A EC IEPI201428230A EC PI201428230 A ECPI201428230 A EC PI201428230A EC SP14028230 A ECSP14028230 A EC SP14028230A
- Authority
- EC
- Ecuador
- Prior art keywords
- treprostinil
- derivatives
- preparation
- same
- allyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
- C07C47/565—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P31/00—Preparation of compounds containing a five-membered ring having two side-chains in ortho position to each other, and having at least one oxygen atom directly bound to the ring in ortho position to one of the side-chains, one side-chain containing, not directly bound to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having at least one oxygen atom bound in gamma-position to the ring, e.g. prostaglandins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Alcoholic Beverages (AREA)
Abstract
Método mejorado para la preparación de treprostinil y sus derivados. En contraste con el arte anterior, este método utiliza una resolución enzimática fácilmente escalable de un intermediario clave para preparar estos compuestos. Otra mejora significativa del método descrito en relación con los métodos anteriores es el reordenamiento regioselectivo de Claisen de un precursor 5-aliloxi-benzaldehído, que está facilitado por un sustituyente bromo en la posición 2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261650836P | 2012-05-23 | 2012-05-23 | |
| EP12172191.4A EP2674413B1 (en) | 2012-06-15 | 2012-06-15 | Process for the preparation of treprostinil and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP14028230A true ECSP14028230A (es) | 2015-09-30 |
Family
ID=46262002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECIEPI201428230A ECSP14028230A (es) | 2012-05-23 | 2014-11-21 | Proceso para la preparacion de treprostinil y derivados del mismo |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US9346738B2 (es) |
| EP (2) | EP2674413B1 (es) |
| JP (1) | JP6219376B2 (es) |
| KR (1) | KR102080264B1 (es) |
| CN (2) | CN107963962A (es) |
| AU (1) | AU2013265351B2 (es) |
| BR (1) | BR112014028969B1 (es) |
| CA (2) | CA3118552C (es) |
| CL (1) | CL2014003165A1 (es) |
| CO (1) | CO7240368A2 (es) |
| CR (1) | CR20140534A (es) |
| CU (1) | CU24274B1 (es) |
| DK (2) | DK2674413T3 (es) |
| DO (1) | DOP2014000266A (es) |
| EA (1) | EA027202B1 (es) |
| EC (1) | ECSP14028230A (es) |
| ES (2) | ES2639823T3 (es) |
| GE (2) | GEP201606548B (es) |
| GT (1) | GT201400262A (es) |
| HR (1) | HRP20171340T1 (es) |
| HU (2) | HUE034485T2 (es) |
| IL (1) | IL235734B (es) |
| LT (1) | LT2674413T (es) |
| MA (1) | MA37611B1 (es) |
| ME (1) | ME02861B (es) |
| MX (1) | MX358418B (es) |
| MY (1) | MY174852A (es) |
| NI (1) | NI201400135A (es) |
| NZ (1) | NZ701041A (es) |
| PE (1) | PE20150712A1 (es) |
| PH (1) | PH12014502604A1 (es) |
| PL (2) | PL2674413T3 (es) |
| PT (2) | PT2674413T (es) |
| RS (1) | RS56304B1 (es) |
| SG (1) | SG11201407662WA (es) |
| SI (1) | SI2674413T1 (es) |
| SM (1) | SMT201700496T1 (es) |
| TN (1) | TN2014000486A1 (es) |
| UA (1) | UA118337C2 (es) |
| WO (1) | WO2013174848A2 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| ES2860975T3 (es) | 2013-10-25 | 2021-10-05 | Insmed Inc | Compuestos de prostaciclina |
| CN111116419B (zh) * | 2014-03-04 | 2022-03-29 | 江苏豪森药业集团有限公司 | 曲前列尼尔中间体及其制备工艺 |
| HU231186B1 (hu) * | 2014-10-08 | 2021-06-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Új eljárás treprostinil és sói előállítására |
| AU2015349969B2 (en) | 2014-11-18 | 2020-02-06 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
| TWI540121B (zh) | 2014-12-01 | 2016-07-01 | 臺灣永光化學工業股份有限公司 | 曲前列環素二乙醇胺之合成方法及新穎中間體 |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| KR101830693B1 (ko) * | 2016-04-28 | 2018-02-21 | 연성정밀화학(주) | 트레프로스티닐의 제조방법 및 이를 위한 중간체 |
| JP7220650B2 (ja) | 2016-09-26 | 2023-02-10 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| EP3498283A1 (en) | 2017-12-14 | 2019-06-19 | Ipsol AG | Glycosidic derivatives of treprostinil |
| CN108875295A (zh) * | 2018-06-21 | 2018-11-23 | 华北电力科学研究院有限责任公司 | 一种利用析因实验设计指导有机物分子修饰改性的方法 |
| CN114072136B (zh) | 2019-04-29 | 2024-11-29 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
| EP4017588A1 (en) | 2019-08-23 | 2022-06-29 | United Therapeutics Corporation | Treprostinil prodrugs |
| JP2023523557A (ja) | 2020-04-17 | 2023-06-06 | ユナイテッド セラピューティクス コーポレイション | 間質性肺疾患の治療における使用のためのトレプロスチニル |
| IL298591A (en) | 2020-06-09 | 2023-01-01 | United Therapeutics Corp | Pomeryl dictopiperidine prodrugs of treprostinil |
| KR20250133451A (ko) | 2020-12-14 | 2025-09-05 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 프로드러그로 질환을 치료하는 방법 |
| JP2024510930A (ja) | 2021-03-03 | 2024-03-12 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニル及びそのプロドラッグの乾燥粉末組成物、及び、さらに（ｅ）－３，６－ビス［４－（ｎ－カルボニル－２－プロペニル）アミドブチル］－２，５－ジケトピペラジン（ｆｄｋｐ）を含む乾燥粉末組成物 |
| WO2023154705A1 (en) | 2022-02-08 | 2023-08-17 | United Therapeutics Corporation | Treprostinil iloprost combination therapy |
| EP4652151A1 (en) | 2023-01-19 | 2025-11-26 | United Therapeutics Corporation | Treprostinil analogs |
| US20250197338A1 (en) | 2023-11-09 | 2025-06-19 | United Therapeutics Corporation | Syntheses of compounds useful for producing treprostinil |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242842B1 (en) | 1996-12-16 | 2001-06-05 | Siemens Matsushita Components Gmbh & Co. Kg | Electrical component, in particular saw component operating with surface acoustic waves, and a method for its production |
| US6441245B1 (en) * | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| US6242482B1 (en) * | 2000-06-05 | 2001-06-05 | United Therapeutics Corporation | Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure |
| US6700025B2 (en) * | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| ES2622471T5 (es) * | 2003-05-22 | 2020-07-23 | United Therapeutics Corp | Compuestos y procedimientos para la administración de análogos de prostaciclina |
| JP6046034B2 (ja) * | 2010-06-03 | 2016-12-14 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルの製造 |
| CA2710726C (en) * | 2010-07-22 | 2016-02-23 | Alphora Research Inc. | Synthesis of treprostinil and intermediates useful therein |
-
2012
- 2012-06-15 LT LTEP12172191.4T patent/LT2674413T/lt unknown
- 2012-06-15 ME MEP-2017-203A patent/ME02861B/me unknown
- 2012-06-15 RS RS20170871A patent/RS56304B1/sr unknown
- 2012-06-15 HU HUE12172191A patent/HUE034485T2/en unknown
- 2012-06-15 EP EP12172191.4A patent/EP2674413B1/en active Active
- 2012-06-15 PL PL12172191T patent/PL2674413T3/pl unknown
- 2012-06-15 SI SI201231051T patent/SI2674413T1/sl unknown
- 2012-06-15 SM SM20170496T patent/SMT201700496T1/it unknown
- 2012-06-15 PT PT121721914T patent/PT2674413T/pt unknown
- 2012-06-15 ES ES12172191.4T patent/ES2639823T3/es active Active
- 2012-06-15 DK DK12172191.4T patent/DK2674413T3/en active
-
2013
- 2013-05-22 WO PCT/EP2013/060472 patent/WO2013174848A2/en not_active Ceased
- 2013-05-22 CN CN201711097647.0A patent/CN107963962A/zh active Pending
- 2013-05-22 DK DK13724809.2T patent/DK2861554T3/en active
- 2013-05-22 PL PL13724809T patent/PL2861554T3/pl unknown
- 2013-05-22 AU AU2013265351A patent/AU2013265351B2/en active Active
- 2013-05-22 JP JP2015513152A patent/JP6219376B2/ja active Active
- 2013-05-22 CN CN201380026921.9A patent/CN104350035B/zh active Active
- 2013-05-22 CA CA3118552A patent/CA3118552C/en active Active
- 2013-05-22 HU HUE13724809A patent/HUE042516T2/hu unknown
- 2013-05-22 GE GEAP201313668A patent/GEP201606548B/en unknown
- 2013-05-22 US US14/401,826 patent/US9346738B2/en active Active
- 2013-05-22 EA EA201401293A patent/EA027202B1/ru not_active IP Right Cessation
- 2013-05-22 MX MX2014014237A patent/MX358418B/es active IP Right Grant
- 2013-05-22 CU CUP2014000135A patent/CU24274B1/es unknown
- 2013-05-22 MA MA37611A patent/MA37611B1/fr unknown
- 2013-05-22 MY MYPI2014003255A patent/MY174852A/en unknown
- 2013-05-22 GE GEAP201714111A patent/GEP20186826B/en unknown
- 2013-05-22 UA UAA201413808A patent/UA118337C2/uk unknown
- 2013-05-22 CA CA2873280A patent/CA2873280C/en active Active
- 2013-05-22 BR BR112014028969-7A patent/BR112014028969B1/pt active IP Right Grant
- 2013-05-22 NZ NZ701041A patent/NZ701041A/en unknown
- 2013-05-22 PE PE2014002058A patent/PE20150712A1/es active IP Right Grant
- 2013-05-22 EP EP13724809.2A patent/EP2861554B1/en active Active
- 2013-05-22 KR KR1020147031805A patent/KR102080264B1/ko active Active
- 2013-05-22 PT PT13724809T patent/PT2861554T/pt unknown
- 2013-05-22 ES ES13724809T patent/ES2702347T3/es active Active
- 2013-05-22 SG SG11201407662WA patent/SG11201407662WA/en unknown
-
2014
- 2014-11-17 IL IL235734A patent/IL235734B/en active IP Right Grant
- 2014-11-21 CR CR20140534A patent/CR20140534A/es unknown
- 2014-11-21 NI NI201400135A patent/NI201400135A/es unknown
- 2014-11-21 CO CO14256345A patent/CO7240368A2/es unknown
- 2014-11-21 CL CL2014003165A patent/CL2014003165A1/es unknown
- 2014-11-21 EC ECIEPI201428230A patent/ECSP14028230A/es unknown
- 2014-11-21 GT GT201400262A patent/GT201400262A/es unknown
- 2014-11-21 DO DO2014000266A patent/DOP2014000266A/es unknown
- 2014-11-21 TN TN2014000486A patent/TN2014000486A1/fr unknown
- 2014-11-21 PH PH12014502604A patent/PH12014502604A1/en unknown
-
2017
- 2017-09-06 HR HRP20171340TT patent/HRP20171340T1/hr unknown
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