ECSP15040888A - PROTEÍNAS DE UNIÓN ESPECÍFICAS DUALES DIRIGIDAS CONTRA TNF alfa - Google Patents
PROTEÍNAS DE UNIÓN ESPECÍFICAS DUALES DIRIGIDAS CONTRA TNF alfaInfo
- Publication number
- ECSP15040888A ECSP15040888A ECIEPI201540888A ECPI201540888A ECSP15040888A EC SP15040888 A ECSP15040888 A EC SP15040888A EC IEPI201540888 A ECIEPI201540888 A EC IEPI201540888A EC PI201540888 A ECPI201540888 A EC PI201540888A EC SP15040888 A ECSP15040888 A EC SP15040888A
- Authority
- EC
- Ecuador
- Prior art keywords
- binding proteins
- tnf alpha
- specific binding
- dual specific
- targeted against
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
Proteínas de unión multivalentes y multiespecíficas manipuladas que se unen a TNF alfa, IL 13, PGE2 y/o a NGF, junto con métodos de elaboración y sus usos en la prevención, el diagnóstico y/o tratamiento de una enfermedad.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361794964P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/028646 WO2014144299A2 (en) | 2013-03-15 | 2014-03-14 | DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST TNFα |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP15040888A true ECSP15040888A (es) | 2015-11-30 |
Family
ID=50639981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECIEPI201540888A ECSP15040888A (es) | 2013-03-15 | 2015-09-23 | PROTEÍNAS DE UNIÓN ESPECÍFICAS DUALES DIRIGIDAS CONTRA TNF alfa |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20140271457A1 (es) |
| EP (1) | EP2970457A2 (es) |
| JP (1) | JP2016517277A (es) |
| KR (1) | KR20150131360A (es) |
| CN (1) | CN105209491A (es) |
| AR (1) | AR095588A1 (es) |
| AU (1) | AU2014227664A1 (es) |
| BR (1) | BR112015023557A2 (es) |
| CA (1) | CA2904407A1 (es) |
| CL (1) | CL2015002743A1 (es) |
| CR (1) | CR20150522A (es) |
| EC (1) | ECSP15040888A (es) |
| IL (1) | IL240915A0 (es) |
| MX (1) | MX2015013170A (es) |
| PE (1) | PE20151670A1 (es) |
| PH (1) | PH12015502007A1 (es) |
| RU (1) | RU2015143833A (es) |
| SG (1) | SG11201507423YA (es) |
| TW (1) | TW201446800A (es) |
| UY (1) | UY35479A (es) |
| WO (1) | WO2014144299A2 (es) |
| ZA (1) | ZA201506582B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2726087A1 (en) | 2008-06-03 | 2009-12-10 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
| BR112012004546A8 (pt) | 2009-08-29 | 2017-12-05 | Abbott Lab | Terapêutica por proteínas ligantes dll4-ligantes |
| KR101853278B1 (ko) | 2010-03-02 | 2018-05-02 | 애브비 인코포레이티드 | 치료학적 dll4 결합 단백질 |
| EP3252072A3 (en) | 2010-08-03 | 2018-03-14 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
| JP2013539364A (ja) | 2010-08-26 | 2013-10-24 | アッヴィ・インコーポレイテッド | 二重可変ドメイン免疫グロブリンおよびその使用 |
| PE20141545A1 (es) | 2011-10-24 | 2014-11-26 | Abbvie Inc | Inmunoenlazadores dirigidos contra el tnf |
| TW201333035A (zh) | 2011-12-30 | 2013-08-16 | Abbvie Inc | 針對il-13及/或il-17之雙特異性結合蛋白 |
| TW202037609A (zh) | 2012-11-01 | 2020-10-16 | 美商艾伯維有限公司 | 抗-vegf/dll4雙重可變區域免疫球蛋白及其用途 |
| WO2014144280A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Inc. | DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1β AND / OR IL-17 |
| LT3099713T (lt) | 2014-02-02 | 2020-07-10 | Medimmune Limited | Chimerinis baltymas, sudarytas iš ngf antagonistinio domeno ir tnfa antagonistinio domeno |
| PL3104853T3 (pl) | 2014-02-10 | 2020-05-18 | Respivant Sciences Gmbh | Leczenie stabilizatorami komórek tucznych zaburzeń ogólnoustrojowych |
| ES2792682T3 (es) | 2014-02-10 | 2020-11-11 | Respivant Sciences Gmbh | Métodos para el tratamiento de enfermedades pulmonares con estabilizadores de mastocitos |
| EA202193002A2 (ru) | 2014-09-03 | 2022-03-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Соединение, нацеленное на ил-23a и фно-альфа, и его применение |
| US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
| US10238625B2 (en) | 2015-08-07 | 2019-03-26 | Respivant Sciences Gmbh | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
| WO2017027402A1 (en) | 2015-08-07 | 2017-02-16 | Patara Pharma, LLC | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
| RS62437B1 (sr) | 2015-10-25 | 2021-11-30 | Sanofi Sa | Trispecifični i/ili trivalentni vezujući proteini za prevenciju ili lečenje hiv infekcije |
| GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
| LT3443006T (lt) | 2016-04-13 | 2023-10-25 | Sanofi | Trispecifiniai ir (arba) trivalenčiai rišantieji baltymai |
| CA3020633A1 (en) * | 2016-04-13 | 2017-10-19 | Sanofi | Trispecific and/or trivalent binding proteins |
| JP6871948B2 (ja) | 2016-04-27 | 2021-05-19 | アッヴィ・インコーポレイテッド | 抗il−13抗体を使用する、il−13活性が有害である疾患の治療方法 |
| WO2018044942A1 (en) | 2016-08-31 | 2018-03-08 | Patara Pharma, LLC | Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis |
| EP3522983A4 (en) | 2016-10-07 | 2020-06-03 | Respivant Sciences GmbH | CROMOLYN COMPOSITION FOR TREATING LUNG FIBROSIS |
| CN107375904B (zh) * | 2017-08-01 | 2020-11-27 | 无锡市人民医院 | β-arrestin1在防治色素障碍性皮肤病中的应用 |
| BR112020007002A2 (pt) | 2017-10-10 | 2020-11-17 | Sanofi | anticorpos anti-cd38 e métodos de uso |
| JP7462621B2 (ja) | 2018-10-09 | 2024-04-05 | サノフイ | 三重特異性抗cd38、抗cd28、および抗cd3結合タンパク質ならびにウイルス感染を処置するための使用方法 |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| KR102267495B1 (ko) * | 2019-08-07 | 2021-06-22 | 연세대학교 산학협력단 | 미토콘드리아 타겟팅용 폴리펩타이드 및 그 용도 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5006309A (en) | 1988-04-22 | 1991-04-09 | Abbott Laboratories | Immunoassay device with liquid transfer between wells by washing |
| US5089424A (en) | 1988-06-14 | 1992-02-18 | Abbott Laboratories | Method and apparatus for heterogeneous chemiluminescence assay |
| US5063081A (en) | 1988-11-14 | 1991-11-05 | I-Stat Corporation | Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor |
| CA2069530A1 (en) | 1991-06-03 | 1992-12-04 | Cass J. Grandone | Reagent pack for immunoassays |
| MX336813B (es) | 1996-02-09 | 2016-02-02 | Abbvie Biotechnology Ltd | Anticuerpos humanos que ligan el tnfa humano. |
| US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
| JP2003531588A (ja) | 2000-04-11 | 2003-10-28 | ジェネンテック・インコーポレーテッド | 多価抗体とその用途 |
| KR100919593B1 (ko) | 2000-06-29 | 2009-09-29 | 아보트 러보러터리즈 | 이중 특이성 항체 및 이의 제조 방법 및 이를 포함하는 조성물 |
| US7419821B2 (en) | 2002-03-05 | 2008-09-02 | I-Stat Corporation | Apparatus and methods for analyte measurement and immunoassay |
| US7241733B2 (en) * | 2002-06-28 | 2007-07-10 | Centocor, Inc. | Mammalian EPO mimetic CH1 deleted mimetibodies, compositions, methods and uses |
| DK2314629T4 (da) | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| US20040018577A1 (en) | 2002-07-29 | 2004-01-29 | Emerson Campbell John Lewis | Multiple hybrid immunoassay |
| US7723099B2 (en) | 2003-09-10 | 2010-05-25 | Abbott Point Of Care Inc. | Immunoassay device with immuno-reference electrode |
| US7682833B2 (en) | 2003-09-10 | 2010-03-23 | Abbott Point Of Care Inc. | Immunoassay device with improved sample closure |
| US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| JP2010502224A (ja) * | 2006-09-08 | 2010-01-28 | アボット・ラボラトリーズ | インターロイキン13結合タンパク質 |
| TWI478937B (zh) | 2008-01-15 | 2015-04-01 | Abbvie Inc | 改良之哺乳動物表現載體及其用途 |
| CA2726087A1 (en) | 2008-06-03 | 2009-12-10 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
| CN102149825B (zh) * | 2008-07-08 | 2015-07-22 | Abbvie公司 | 前列腺素e2双重可变结构域免疫球蛋白及其用途 |
| RU2011127198A (ru) * | 2008-12-04 | 2013-01-10 | Эбботт Лэборетриз | Иммуноглобулины с двойными вариабельными доменами и их применение |
| BR112012008833A2 (pt) * | 2009-10-15 | 2015-09-08 | Abbott Lab | imunoglobulinas de dominio variavel duplo e usos das mesmas |
| UY32979A (es) * | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| EP3252072A3 (en) * | 2010-08-03 | 2018-03-14 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
| RU2014121043A (ru) * | 2011-10-24 | 2015-12-10 | Эббви Инк. | Биспецифические иммуносвязывающие средства, направленные против tnf и il-17 |
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2014
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- 2014-03-14 KR KR1020157029888A patent/KR20150131360A/ko not_active Withdrawn
- 2014-03-14 MX MX2015013170A patent/MX2015013170A/es unknown
- 2014-03-14 AU AU2014227664A patent/AU2014227664A1/en not_active Abandoned
- 2014-03-14 CA CA2904407A patent/CA2904407A1/en not_active Abandoned
- 2014-03-14 RU RU2015143833A patent/RU2015143833A/ru not_active Application Discontinuation
- 2014-03-14 EP EP14721652.7A patent/EP2970457A2/en not_active Withdrawn
- 2014-03-14 PE PE2015001934A patent/PE20151670A1/es not_active Application Discontinuation
- 2014-03-14 BR BR112015023557A patent/BR112015023557A2/pt not_active IP Right Cessation
- 2014-03-14 TW TW103109732A patent/TW201446800A/zh unknown
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- 2014-03-14 SG SG11201507423YA patent/SG11201507423YA/en unknown
- 2014-03-14 US US14/211,596 patent/US20140271457A1/en not_active Abandoned
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2015
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- 2015-09-23 EC ECIEPI201540888A patent/ECSP15040888A/es unknown
- 2015-10-08 CR CR20150522A patent/CR20150522A/es unknown
Also Published As
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| TW201446800A (zh) | 2014-12-16 |
| CR20150522A (es) | 2016-01-12 |
| CA2904407A1 (en) | 2014-09-18 |
| CN105209491A (zh) | 2015-12-30 |
| JP2016517277A (ja) | 2016-06-16 |
| IL240915A0 (en) | 2015-10-29 |
| BR112015023557A2 (pt) | 2017-10-24 |
| RU2015143833A (ru) | 2017-04-21 |
| KR20150131360A (ko) | 2015-11-24 |
| EP2970457A2 (en) | 2016-01-20 |
| US20140271457A1 (en) | 2014-09-18 |
| MX2015013170A (es) | 2016-07-26 |
| WO2014144299A2 (en) | 2014-09-18 |
| CL2015002743A1 (es) | 2016-03-18 |
| AR095588A1 (es) | 2015-10-28 |
| AU2014227664A8 (en) | 2015-10-15 |
| AU2014227664A1 (en) | 2015-09-24 |
| PH12015502007A1 (en) | 2016-01-11 |
| WO2014144299A3 (en) | 2014-12-18 |
| PE20151670A1 (es) | 2015-12-12 |
| SG11201507423YA (en) | 2015-10-29 |
| UY35479A (es) | 2014-09-30 |
| ZA201506582B (en) | 2017-01-25 |
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