ECSP16087271A - PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES - Google Patents

PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES

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Publication number
ECSP16087271A
ECSP16087271A ECIEPI201687271A ECPI201687271A ECSP16087271A EC SP16087271 A ECSP16087271 A EC SP16087271A EC IEPI201687271 A ECIEPI201687271 A EC IEPI201687271A EC PI201687271 A ECPI201687271 A EC PI201687271A EC SP16087271 A ECSP16087271 A EC SP16087271A
Authority
EC
Ecuador
Prior art keywords
pyrazolopyridines
pyrazolopyrimidines
please see
see attached
attached
Prior art date
Application number
ECIEPI201687271A
Other languages
Spanish (es)
Inventor
Gavin Alistair Whitlock
Christoph Martin Dehnhardt
Jotham Wadsworth Coe
Joseph Walter Strohbach
Yogesh Anil Sabnis
Peter Jones
Florian Michel Wakenhut
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53264695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP16087271(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of ECSP16087271A publication Critical patent/ECSP16087271A/en

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)

Abstract

fAVOR VER ADJUNTOPlease see attached

ECIEPI201687271A 2014-05-14 2016-11-11 PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES ECSP16087271A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461993138P 2014-05-14 2014-05-14

Publications (1)

Publication Number Publication Date
ECSP16087271A true ECSP16087271A (en) 2018-05-31

Family

ID=53264695

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201687271A ECSP16087271A (en) 2014-05-14 2016-11-11 PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES

Country Status (29)

Country Link
US (2) US9518052B2 (en)
EP (1) EP3143021B1 (en)
JP (1) JP6663857B2 (en)
KR (1) KR20170002623A (en)
CN (1) CN106459048A (en)
AP (1) AP2016009562A0 (en)
AR (1) AR100438A1 (en)
AU (1) AU2015260905A1 (en)
CA (1) CA2948587C (en)
CL (1) CL2016002888A1 (en)
CR (1) CR20160525A (en)
CU (1) CU20160167A7 (en)
DO (1) DOP2016000298A (en)
EA (1) EA201650029A1 (en)
EC (1) ECSP16087271A (en)
ES (1) ES2737696T3 (en)
GE (2) GEP20186921B (en)
IL (1) IL248970A0 (en)
MD (1) MD20160121A2 (en)
MX (1) MX2016014878A (en)
NI (1) NI201600170A (en)
PE (1) PE20161475A1 (en)
PH (1) PH12016502228A1 (en)
SG (1) SG11201609139WA (en)
SV (1) SV2016005318A (en)
TN (1) TN2016000503A1 (en)
TW (1) TWI591067B (en)
UY (1) UY36121A (en)
WO (1) WO2015173683A1 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170002623A (en) 2014-05-14 2017-01-06 화이자 인코포레이티드 Pyrazolopyridines and pyrazolopyrimidines
US9403810B2 (en) 2014-05-14 2016-08-02 Novartis Ag Carboxamide derivatives
WO2017077283A1 (en) 2015-11-03 2017-05-11 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
DK3371185T3 (en) 2015-11-03 2020-11-30 Topivert Pharma Ltd 4,5,6,7-TETRAHYDRO-1H-IMIDAZO [4,5-C] PYRIDINE AND 1,4,5,6,7,8-HEXAHYDROIMIDAZO [4,5-D] AZEPINE DERIVATIVES AS JANUS CHINASE INHIBITORS
UA123633C2 (en) * 2015-11-03 2021-05-05 Тереванс Байофарма Ар Енд Ді Айпі, Елелсі JAK-KINASE INHIBITOR COMPOUNDS FOR TREATMENT OF RESPIRATORY DISEASE
WO2018165392A1 (en) 2017-03-09 2018-09-13 Theravance Biopharma R&D Ip, Llc Jak inhibitors containing a 4-membered heterocyclic amide
WO2018204233A1 (en) 2017-05-01 2018-11-08 Theravance Biopharma R&D Ip, Llc Methods of treatment using a jak inhibitor compound
KR20200003121A (en) 2017-05-01 2020-01-08 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Crystalline Forms of JAK Inhibitor Compounds
AR111495A1 (en) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc FUSIONED IMIDAZO-PIPERIDINE COMPOUNDS AS JAK INHIBITORS
AU2018312349A1 (en) 2017-08-01 2020-02-06 Theravance Biopharma R&D Ip, Llc Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors
KR102821964B1 (en) 2017-11-03 2025-06-19 어클라리스 쎄라퓨틱스, 인코포레이티드 Substituted pyrrolopyrimidine JAK inhibitors and methods for their manufacture and use
US11554120B2 (en) * 2018-08-03 2023-01-17 Bristol-Myers Squibb Company 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
CN119080779A (en) 2018-08-10 2024-12-06 阿克拉瑞斯治疗股份有限公司 Pyrrolopyrimidine ITK inhibitors
CN110833555B (en) * 2018-08-15 2023-03-24 广西梧州制药（集团）股份有限公司 Use of pyrazolopyrimidine derivatives for the treatment of ulcerative colitis
FI3837258T3 (en) 2018-09-04 2024-05-27 Theravance Biopharma R&D Ip Llc Dimethyl amino azetidine amides as jak inhibitors
JP2021535176A (en) 2018-09-04 2021-12-16 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Process for preparing JAK inhibitors and their intermediates
UA127328C2 (en) 2018-09-04 2023-07-19 Тереванс Байофарма Ар Енд Ді Айпі, Елелсі 5 to 7 membered heterocyclic amides as jak inhibitors
KR20210084512A (en) 2018-10-29 2021-07-07 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 2-azabicyclohexane compound as a JAK inhibitor
CN113498352A (en) 2019-01-23 2021-10-12 施万生物制药研发Ip有限责任公司 Imidazo [1,5-A ] pyridines, 1,2, 4-triazolo [4,3-A ] pyridines and imidazo [1,5-A ] pyrazines as JAK inhibitors
HUE067145T2 (en) * 2019-02-25 2024-10-28 Henan Medinno Pharmaceutical Tech Co Ltd Jak inhibitor compound and use thereof
CN114075199B (en) * 2020-08-14 2026-03-10 河南迈英诺医药科技有限公司 JAK inhibitor compounds and uses thereof
CN114075200A (en) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 JAK inhibitor compounds for the treatment of severe pneumonia
CA3138544A1 (en) 2019-05-02 2020-11-05 Aclaris Therapeutics, Inc. Substituted pyrrolopyridines as jak inhibitors
US20220235043A1 (en) * 2019-07-31 2022-07-28 Aclaris Therapeutics, Inc. Substituted sulfonamide pyrrolopyridines as jak inhibitors
JP7580136B2 (en) * 2019-12-30 2024-11-11 路良 JAK inhibitor compounds and uses thereof
TWI885039B (en) 2020-01-13 2025-06-01 美商邊際分析公司 Substituted pyrazolo-pyrimidines and uses thereof
CN113101975B (en) * 2020-01-13 2022-04-22 万华化学集团股份有限公司 Multi-phosphine ligand catalyst system and application thereof in ethylene oligomerization reaction
TW202144343A (en) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Crystalline hydrate of a jak inhibitor compound
CN111548269B (en) * 2020-04-29 2023-10-27 兰州大学 Preparation method of diarylmethane structural compound
GB202010408D0 (en) * 2020-07-07 2020-08-19 Reviral Ltd Pharmaceutical compounds
JP2023541601A (en) 2020-09-10 2023-10-03 プレシリックス・ナームローゼ・ベンノートシヤープ Antibody fragment against FAP
EP4359402B1 (en) 2021-06-25 2026-03-11 Theravance Biopharma R&D IP, LLC Imidazolo indazole compounds as jak inhibitors
CN115557947B (en) * 2021-07-02 2024-04-02 成都百裕制药股份有限公司 Pyrazolo [4,3-c ] pyridine derivative and application thereof in medicine
CN113480543B (en) * 2021-07-07 2022-05-17 无锡市第二人民医院 2,6, 8-polysubstituted imidazo [1,2-a ] pyrazine and synthetic method and application thereof
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
AU2023264245A1 (en) 2022-05-02 2024-12-19 Precirix N.V. Pre-targeting
WO2025217560A1 (en) * 2024-04-12 2025-10-16 Theravance Biopharma R&D Ip, Llc Triazolo indazole compounds as jak inhibitors
WO2025240333A1 (en) * 2024-05-13 2025-11-20 The Texas A&M University System Jak3 targeted smart drugs and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (en) 1990-01-23 1999-01-15 . Cyclodextrin derivatives with increased water solubility and uses thereof
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US20030139427A1 (en) * 2002-08-23 2003-07-24 Osi Pharmaceuticals Inc. Bicyclic pyrimidinyl derivatives and methods of use thereof
WO2004046107A1 (en) 2002-11-19 2004-06-03 Takeda Pharmaceutical Company Limited Indole derivatives as somatostatin agonists or antagonists
US20080234262A1 (en) * 2007-03-21 2008-09-25 Wyeth Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
CN101678215B (en) 2007-04-18 2014-10-01 辉瑞产品公司 Sulfonamide derivatives for the treatment of abnormal cell growth
EA201000484A1 (en) * 2007-10-16 2010-12-30 ВАЙЕТ ЭлЭлСи THYENOPYRIMIDINE AND PYRAZOLOPIRIMIDIN COMPOUNDS AND THEIR APPLICATION AS INHIBITORS MTOR KINASE AND PI3 KINASE
CA2705303A1 (en) * 2007-11-07 2009-05-14 Foldrx Pharmaceuticals, Inc. Modulation of protein trafficking
US20090149458A1 (en) * 2007-11-27 2009-06-11 Wyeth PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS
CA2712267A1 (en) * 2008-01-15 2009-07-23 Wyeth Llc 3h-[1,2,3]triazolo[4,5-d]pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses
US8987280B2 (en) * 2008-01-30 2015-03-24 Genentech, Inc. Pyrazolopyrimidine PI3K inhibitor compounds and methods of use
US8163743B2 (en) * 2008-06-05 2012-04-24 GlaxoGroupLimited 4-carboxamide indazole derivatives useful as inhibitors of PI3-kinases
WO2009153261A1 (en) * 2008-06-18 2009-12-23 Solvay Pharmaceuticals Gmbh HYDROXYPHENYL-SUBSTITUTED PYRROLO[2,3d]PYRIMIDINE DERIVATIVES, PROCESSES AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS
EP2361902A4 (en) 2008-11-21 2012-04-25 Astellas Pharma Inc 4,6-diaminonicotinamide compound
EP2408772B1 (en) * 2009-03-19 2015-07-01 Medical Research Council Technology Compounds
WO2012045195A1 (en) 2010-10-09 2012-04-12 Abbott Laboratories Pyrrolopyrimidines as fak and alk inhibiters for treatment of cancers and other diseases
US8575336B2 (en) * 2011-07-27 2013-11-05 Pfizer Limited Indazoles
KR20170002623A (en) 2014-05-14 2017-01-06 화이자 인코포레이티드 Pyrazolopyridines and pyrazolopyrimidines

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