ECSP18060848A - Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[ 4.5]-decano - Google Patents

Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[ 4.5]-decano

Info

Publication number
ECSP18060848A
ECSP18060848A ECSENADI201860848A ECDI201860848A ECSP18060848A EC SP18060848 A ECSP18060848 A EC SP18060848A EC SENADI201860848 A ECSENADI201860848 A EC SENADI201860848A EC DI201860848 A ECDI201860848 A EC DI201860848A EC SP18060848 A ECSP18060848 A EC SP18060848A
Authority
EC
Ecuador
Prior art keywords
diaza
decane
spiro
hetero
oxo
Prior art date
Application number
ECSENADI201860848A
Other languages
English (en)
Inventor
Ruth Jostock
René Michael Koenigs
Paul Ratcliffe
Sven Kühnert
Wolfgang Schröder
Klaus Linz
Thomas Koch
Anita Wegert
Klaus Schiene
Ingo Konetzki
Achim Kless
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of ECSP18060848A publication Critical patent/ECSP18060848A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano, su preparación y su uso en medicamentos, en particular en el tratamiento del dolor.
ECSENADI201860848A 2016-01-13 2018-08-13 Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[ 4.5]-decano ECSP18060848A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16151013 2016-01-13

Publications (1)

Publication Number Publication Date
ECSP18060848A true ECSP18060848A (es) 2018-08-31

Family

ID=55129634

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI201860848A ECSP18060848A (es) 2016-01-13 2018-08-13 Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[ 4.5]-decano

Country Status (28)

Country Link
US (6) US20170197947A1 (es)
EP (1) EP3402784B1 (es)
JP (1) JP6893517B2 (es)
KR (1) KR20180098369A (es)
CN (1) CN108602777B (es)
AR (1) AR107360A1 (es)
AU (1) AU2017206909B2 (es)
BR (1) BR112018014303B1 (es)
CA (1) CA3011177A1 (es)
CL (1) CL2018001912A1 (es)
CO (1) CO2018008444A2 (es)
CY (1) CY1122818T1 (es)
DK (1) DK3402784T3 (es)
EA (1) EA037481B1 (es)
EC (1) ECSP18060848A (es)
ES (1) ES2797904T3 (es)
HR (1) HRP20200837T1 (es)
HU (1) HUE049813T2 (es)
IL (1) IL260491B (es)
LT (1) LT3402784T (es)
MX (1) MX378994B (es)
PE (1) PE20181375A1 (es)
PL (1) PL3402784T3 (es)
PT (1) PT3402784T (es)
RS (1) RS60315B1 (es)
SI (1) SI3402784T1 (es)
TW (1) TWI636048B (es)
WO (1) WO2017121648A1 (es)

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PL3402784T3 (pl) 2016-01-13 2020-09-21 Grünenthal GmbH Pochodne 3-((hetero-)arylo)-alkilo-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekanu
MX378995B (es) 2016-01-13 2025-03-11 Gruenenthal Gmbh Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.
PL3722284T3 (pl) 2016-01-13 2025-03-31 Grünenthal GmbH Pochodne 3-((hetero-)arylo)-8-amino-2-okso-1,3-diazaspiro-[4.5]-dekanu
MX379201B (es) 2016-01-13 2025-03-11 Gruenenthal Gmbh Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.
LT3402782T (lt) 2016-01-13 2020-10-12 Grünenthal GmbH 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekano dariniai
UA127357C2 (uk) 2018-04-18 2023-07-26 Констеллатіон Фармацеутікалс, Інк. Модулятори метилмодифікуючих ферментів, композиції та їх використання
EP3797108B1 (en) 2018-05-21 2022-07-20 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
TWI827785B (zh) 2019-01-11 2024-01-01 德商歌林達有限公司 經取代的吡咯啶醯胺iii
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds
MD4003532T2 (ro) 2019-07-24 2025-01-31 Constellation Pharmaceuticals Inc Forme cristaline de 7-clor-2-(4-(3-metoxiazetidin-1-il)ciclohexil)-2,4-dimetil-N-((6-metil-4-(metiltio)-2-oxo-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioxol-5-carboxamidă
IL321707A (en) * 2022-12-28 2025-08-01 Gilgamesh Pharmaceuticals Inc Synthesis of 2-phenyl-2-amino-cyclohexan-1-one history
US20240400537A1 (en) 2023-04-25 2024-12-05 Gruenenthal Gmbh Cis-8-(3,5-difluorophenyl)-8-(dimethylamino)-1,3-diazaspiro[4.5]decan-2-one derivatives

Family Cites Families (22)

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FR2734265B1 (fr) 1995-05-17 1997-06-13 Adir Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant
AU2002303406B2 (en) 2001-04-18 2006-03-30 Euro-Celtique S.A. Nociceptin analogs
DE10130020A1 (de) 2001-06-25 2003-12-04 Gruenenthal Gmbh Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
DE10210195B4 (de) 2002-03-07 2005-12-15 Schwarz Pharma Ag Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz
BR0312414A (pt) 2002-07-05 2005-05-10 Targacept Inc Compostos de n-aril diazaespirociclico e métodos para a preparação e uso dos mesmos
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
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JO2676B1 (en) 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
JP5079011B2 (ja) 2006-10-19 2012-11-21 エフ．ホフマン−ラ ロシュ アーゲー 糖尿病のための１１β−ＨＳＤ１阻害剤としてのイミダゾロン及びイミダゾリジノン誘導体
WO2008124209A1 (en) 2007-04-09 2008-10-16 Janssen Pharmaceutica, N.V. 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
MX2010010407A (es) * 2008-03-27 2010-10-25 Gruenenthal Gmbh Derivados de 4-aminociclohexanos sustituidos.
WO2010151815A2 (en) 2009-06-25 2010-12-29 Abbott Laboratories 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
TWI582092B (zh) 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物
WO2014106238A1 (en) * 2012-12-31 2014-07-03 Fang, Qun, Kevin Heterocyclic compounds and methods of use thereof
MA40170A (fr) 2014-06-13 2017-04-19 Purdue Pharma Lp Dérivés hétérocycliques de morphinan et leur utilisation
PL3402784T3 (pl) 2016-01-13 2020-09-21 Grünenthal GmbH Pochodne 3-((hetero-)arylo)-alkilo-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekanu
MX378995B (es) 2016-01-13 2025-03-11 Gruenenthal Gmbh Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.
MX379201B (es) 2016-01-13 2025-03-11 Gruenenthal Gmbh Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.
PL3722284T3 (pl) 2016-01-13 2025-03-31 Grünenthal GmbH Pochodne 3-((hetero-)arylo)-8-amino-2-okso-1,3-diazaspiro-[4.5]-dekanu
AR107354A1 (es) 2016-01-13 2018-04-18 Bristol Myers Squibb Co Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock
HUE058647T2 (hu) 2016-01-13 2022-09-28 Novo Nordisk As Zsírsav szubsztituenseket tartalmazó EGF(A) analógok
LT3402782T (lt) 2016-01-13 2020-10-12 Grünenthal GmbH 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekano dariniai

Also Published As

Publication number Publication date
SI3402784T1 (sl) 2020-07-31
AU2017206909B2 (en) 2020-07-09
EA201891609A1 (ru) 2019-01-31
TW201731822A (zh) 2017-09-16
US20200002319A1 (en) 2020-01-02
EA037481B1 (ru) 2021-04-01
AU2017206909A1 (en) 2018-08-30
HUE049813T2 (hu) 2020-10-28
US20230174520A1 (en) 2023-06-08
KR20180098369A (ko) 2018-09-03
EP3402784B1 (en) 2020-03-11
JP2019501939A (ja) 2019-01-24
IL260491B (en) 2021-07-29
BR112018014303A2 (pt) 2018-12-11
CN108602777B (zh) 2022-05-03
RS60315B1 (sr) 2020-07-31
TWI636048B (zh) 2018-09-21
EP3402784A1 (en) 2018-11-21
NZ745188A (en) 2024-05-31
PT3402784T (pt) 2020-06-18
LT3402784T (lt) 2020-06-10
US20210179592A1 (en) 2021-06-17
HRP20200837T1 (hr) 2020-08-07
DK3402784T3 (da) 2020-05-25
AR107360A1 (es) 2018-04-25
CN108602777A (zh) 2018-09-28
BR112018014303B1 (pt) 2023-10-03
CY1122818T1 (el) 2021-05-05
ES2797904T3 (es) 2020-12-04
CO2018008444A2 (es) 2018-08-31
WO2017121648A1 (en) 2017-07-20
US20170197947A1 (en) 2017-07-13
PE20181375A1 (es) 2018-08-28
JP6893517B2 (ja) 2021-06-23
PL3402784T3 (pl) 2020-09-21
MX378994B (es) 2025-03-11
CL2018001912A1 (es) 2018-10-19
CA3011177A1 (en) 2017-07-20
US20180327392A1 (en) 2018-11-15
US20200399252A1 (en) 2020-12-24
MX2018008644A (es) 2018-11-19
US10829480B2 (en) 2020-11-10

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